ES2155350B1 - PREPARATION PROCEDURE FOR AN ORBALLY ACTIVE CEFALOSPORINE ANTIBIOTIC, CEFIXIME. - Google Patents

PREPARATION PROCEDURE FOR AN ORBALLY ACTIVE CEFALOSPORINE ANTIBIOTIC, CEFIXIME.

Info

Publication number
ES2155350B1
ES2155350B1 ES009802178A ES9802178A ES2155350B1 ES 2155350 B1 ES2155350 B1 ES 2155350B1 ES 009802178 A ES009802178 A ES 009802178A ES 9802178 A ES9802178 A ES 9802178A ES 2155350 B1 ES2155350 B1 ES 2155350B1
Authority
ES
Spain
Prior art keywords
cefixime
antibiotic
orbally
cefalosporine
active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES009802178A
Other languages
Spanish (es)
Other versions
ES2155350A1 (en
Inventor
Debashis Das
Sharma Anil Kumar
Arun Malhotra
Sisodia Anuja Chauhan
Baldev Raj
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
J K IND Ltd
Original Assignee
J K IND Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J K IND Ltd filed Critical J K IND Ltd
Publication of ES2155350A1 publication Critical patent/ES2155350A1/en
Application granted granted Critical
Publication of ES2155350B1 publication Critical patent/ES2155350B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Procedimiento de preparación de un antibiótico de cefalosporina oralmente activo, Cefixime. La presente invención se refiere a un procedimiento para la preparación de antibiótico de cefalosporina oralmente activo - Cefixime, de fórmula I en el que, a temperatura ambiente y durante 1,5 a 2 horas se hace reaccionar el éster de la fórmula II de base inorgánica en una mezcla de dimetilformamida (DMF) y agua, aislando el Cefixime de la pureza requerida, mediante acidificación de la mezcla resultante de la reacción y secado.Procedure for preparing an orally active cephalosporin antibiotic, Cefixime. The present invention relates to a process for the preparation of orally active cephalosporin antibiotic - Cefixime, of formula I in which, at room temperature and for 1.5 to 2 hours, the ester of inorganic base formula II is reacted in a mixture of dimethylformamide (DMF) and water, isolating the Cefixime from the required purity, by acidification of the mixture resulting from the reaction and drying.

ES009802178A 1997-10-08 1998-10-08 PREPARATION PROCEDURE FOR AN ORBALLY ACTIVE CEFALOSPORINE ANTIBIOTIC, CEFIXIME. Expired - Fee Related ES2155350B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT102061A PT102061B (en) 1997-10-08 1997-10-08 PROCESS OF PREPARATION OF AN ECHALOSPORIN ANTIBIOTIC ACID GENERALLY ACTIVE-CEFIXIME

Publications (2)

Publication Number Publication Date
ES2155350A1 ES2155350A1 (en) 2001-05-01
ES2155350B1 true ES2155350B1 (en) 2001-12-01

Family

ID=20085702

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009802178A Expired - Fee Related ES2155350B1 (en) 1997-10-08 1998-10-08 PREPARATION PROCEDURE FOR AN ORBALLY ACTIVE CEFALOSPORINE ANTIBIOTIC, CEFIXIME.

Country Status (4)

Country Link
DE (1) DE19846448A1 (en)
ES (1) ES2155350B1 (en)
GB (1) GB2330140A (en)
PT (1) PT102061B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008478B2 (en) 2004-12-21 2011-08-30 Lupin Limited Process for the preparation of cefixime
WO2006103686A1 (en) 2005-03-29 2006-10-05 Hetero Drugs Limited An improved process for the preparation of cefixime
CN102731529A (en) * 2012-06-28 2012-10-17 广州白云山制药股份有限公司广州白云山化学制药厂 Refining method for cefixime

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4694079A (en) * 1985-07-29 1987-09-15 Bristol-Myers Company 3-propenyl cephalosporin solvates
CH688319A5 (en) * 1994-06-03 1997-07-31 Marcham Trading & Investment L Process for the preparation of cefixime trihydrate.
TW538045B (en) * 1997-01-16 2003-06-21 Biochemie Gmbh Process for purifying cefixime

Also Published As

Publication number Publication date
PT102061B (en) 2000-06-30
DE19846448A1 (en) 1999-04-15
PT102061A (en) 1998-06-30
GB2330140A (en) 1999-04-14
ES2155350A1 (en) 2001-05-01
GB9821966D0 (en) 1998-12-02

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