ES2153789A1 - Procedimiento para la obtencion de 178-(n-terc-butlcarbamoil)-3-ona-4-aza-esteroides - Google Patents
Procedimiento para la obtencion de 178-(n-terc-butlcarbamoil)-3-ona-4-aza-esteroidesInfo
- Publication number
- ES2153789A1 ES2153789A1 ES009901487A ES9901487A ES2153789A1 ES 2153789 A1 ES2153789 A1 ES 2153789A1 ES 009901487 A ES009901487 A ES 009901487A ES 9901487 A ES9901487 A ES 9901487A ES 2153789 A1 ES2153789 A1 ES 2153789A1
- Authority
- ES
- Spain
- Prior art keywords
- aza
- butylcarbamoyl
- steroids
- 17beta
- terc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Steroid Compounds (AREA)
Abstract
Procedimiento de obtención de 17{be}-(n-terc-butilcarbamoil)-3- ona-4-aza-esteroides. Los 17{be}-(N-terc-butilcarbamoil)3-ona-4- aza-esteroides (I) pueden obtenerse mediante un procedimiento que comprende hacer reaccionar un 17{be}-(alcoxicarbonil)-3-ona-4- azaesteroide con un terc-butilamiduro de litio en un disolvente orgánico. Algunos compuestos de fórmula (I), por ejemplo, la finasterida, son útiles como inhibidores de la 5{al}-reductasa, y pueden ser utilizados en el tratamiento de la hiperplasia prostática benigna y la alopecia.
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009901487A ES2153789B1 (es) | 1999-07-05 | 1999-07-05 | Procedimiento para la obtencion de 178-(n-terc-butlcarbamoil)-3-ona-4-aza-esteroides |
HU0103002A HUP0103002A3 (en) | 1999-07-05 | 2000-07-05 | New process for obtaining 17betha-(n-terc-butylcarbamoyl)-3-one-4-aza-steroids |
JP2001507858A JP2003503507A (ja) | 1999-07-05 | 2000-07-05 | 17β(N−TERC−BUTYLCARBAMOYL)−3−ONE−4−AZA−STEROIDの製造方法 |
DE60007716T DE60007716T2 (de) | 1999-07-05 | 2000-07-05 | Verfahren zur gewinnung von 17beta-(n-tert-butylcarbamoyl)-3-on-4-aza-steroiden |
AT00940431T ATE257842T1 (de) | 1999-07-05 | 2000-07-05 | Verfahren zur gewinnung von 17beta-(n-tert- butylcarbamoyl)-3-on-4-aza-steroiden |
PCT/ES2000/000239 WO2001002422A1 (es) | 1999-07-05 | 2000-07-05 | PROCEDIMIENTO PARA LA OBTENCION DE 17β-(N-TERC-BUTILCARBAMOIL)-3-ONA-4-AZA-ESTEROIDES |
EP00940431A EP1116725B1 (en) | 1999-07-05 | 2000-07-05 | Process for obtaining 17beta-(n-terc-butylcarbamoyl)-3-one-4-aza-steroids |
CA002342864A CA2342864A1 (en) | 1999-07-05 | 2000-07-05 | Process for obtaining 17.beta.-(n-terc-butylcarbamoyl)-3-one-4-aza-steroids |
US09/800,019 US6509466B2 (en) | 1999-07-05 | 2001-03-05 | Process for obtaining 17 β-(N-tert-butylcarbamoyl)-3-one-4-aza-steroids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009901487A ES2153789B1 (es) | 1999-07-05 | 1999-07-05 | Procedimiento para la obtencion de 178-(n-terc-butlcarbamoil)-3-ona-4-aza-esteroides |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2153789A1 true ES2153789A1 (es) | 2001-03-01 |
ES2153789B1 ES2153789B1 (es) | 2001-10-16 |
Family
ID=8309089
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009901487A Expired - Fee Related ES2153789B1 (es) | 1999-07-05 | 1999-07-05 | Procedimiento para la obtencion de 178-(n-terc-butlcarbamoil)-3-ona-4-aza-esteroides |
Country Status (9)
Country | Link |
---|---|
US (1) | US6509466B2 (es) |
EP (1) | EP1116725B1 (es) |
JP (1) | JP2003503507A (es) |
AT (1) | ATE257842T1 (es) |
CA (1) | CA2342864A1 (es) |
DE (1) | DE60007716T2 (es) |
ES (1) | ES2153789B1 (es) |
HU (1) | HUP0103002A3 (es) |
WO (1) | WO2001002422A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100415858B1 (ko) * | 2001-09-22 | 2004-01-24 | 한미약품 주식회사 | 17베타-(엔-3차-부틸카바모일)-3-온 스테로이드 화합물의제조방법 |
US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
FR3106058B1 (fr) * | 2020-01-09 | 2022-01-07 | Oreal | Procédé de traitement cosmétique |
CN114213502B (zh) * | 2021-12-08 | 2024-02-13 | 湖南醇健制药科技有限公司 | 一种非那雄胺的精制方法及非那雄胺制剂和其制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0367502A1 (en) * | 1988-10-31 | 1990-05-09 | Merck & Co. Inc. | Methods of synthesizing benign prostatic hypertrophic agents |
EP0599376A2 (en) * | 1992-11-19 | 1994-06-01 | Merck & Co. Inc. | A process for the production of finasteride |
WO1995000531A1 (en) * | 1993-06-24 | 1995-01-05 | Richter Gedeon Vegyészeti Gyár Rt. | NOVEL PROCESS FOR PREPARING 17β-SUBSTITUTED 4-AZAANDROSTANE DERIVATIVES |
US5670643A (en) * | 1995-03-16 | 1997-09-23 | Glaxo Wellcome Inc. | Method for preparing finasteride |
GB2338234A (en) * | 1998-06-10 | 1999-12-15 | Torcan Chemical Ltd | Finasteride preparation |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4760071A (en) | 1984-02-27 | 1988-07-26 | Merck & Co., Inc. | 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors |
-
1999
- 1999-07-05 ES ES009901487A patent/ES2153789B1/es not_active Expired - Fee Related
-
2000
- 2000-07-05 HU HU0103002A patent/HUP0103002A3/hu unknown
- 2000-07-05 AT AT00940431T patent/ATE257842T1/de not_active IP Right Cessation
- 2000-07-05 JP JP2001507858A patent/JP2003503507A/ja active Pending
- 2000-07-05 DE DE60007716T patent/DE60007716T2/de not_active Expired - Fee Related
- 2000-07-05 CA CA002342864A patent/CA2342864A1/en not_active Abandoned
- 2000-07-05 WO PCT/ES2000/000239 patent/WO2001002422A1/es active IP Right Grant
- 2000-07-05 EP EP00940431A patent/EP1116725B1/en not_active Expired - Lifetime
-
2001
- 2001-03-05 US US09/800,019 patent/US6509466B2/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0367502A1 (en) * | 1988-10-31 | 1990-05-09 | Merck & Co. Inc. | Methods of synthesizing benign prostatic hypertrophic agents |
EP0599376A2 (en) * | 1992-11-19 | 1994-06-01 | Merck & Co. Inc. | A process for the production of finasteride |
WO1995000531A1 (en) * | 1993-06-24 | 1995-01-05 | Richter Gedeon Vegyészeti Gyár Rt. | NOVEL PROCESS FOR PREPARING 17β-SUBSTITUTED 4-AZAANDROSTANE DERIVATIVES |
US5670643A (en) * | 1995-03-16 | 1997-09-23 | Glaxo Wellcome Inc. | Method for preparing finasteride |
GB2338234A (en) * | 1998-06-10 | 1999-12-15 | Torcan Chemical Ltd | Finasteride preparation |
Non-Patent Citations (1)
Title |
---|
PENG XIA y col. Synthesis of N-Substituted 3-Oxo-17beta-Carboxamide-4-Aza-5alpha-Androstanes and the Tautomerism of 3-Oxo-4-Aza-5-Androstenes1. Heterocycles, 1998, Vol. 47, No 2, paginas 703-716. Pagina 703, esquema 1. * |
Also Published As
Publication number | Publication date |
---|---|
EP1116725A1 (en) | 2001-07-18 |
DE60007716D1 (de) | 2004-02-19 |
ATE257842T1 (de) | 2004-01-15 |
US6509466B2 (en) | 2003-01-21 |
WO2001002422A9 (es) | 2001-04-05 |
US20010008895A1 (en) | 2001-07-19 |
DE60007716T2 (de) | 2004-12-09 |
WO2001002422A1 (es) | 2001-01-11 |
HUP0103002A3 (en) | 2002-09-30 |
CA2342864A1 (en) | 2001-01-11 |
EP1116725B1 (en) | 2004-01-14 |
ES2153789B1 (es) | 2001-10-16 |
JP2003503507A (ja) | 2003-01-28 |
HUP0103002A2 (hu) | 2002-01-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20010301 Kind code of ref document: A1 Effective date: 20010301 |
|
PC2A | Transfer of patent | ||
FD1A | Patent lapsed |
Effective date: 20100312 |