ES2149760T3 - Procedimiento para la recuperacion de celulas fetales. - Google Patents

Procedimiento para la recuperacion de celulas fetales.

Info

Publication number
ES2149760T3
ES2149760T3 ES91906073T ES91906073T ES2149760T3 ES 2149760 T3 ES2149760 T3 ES 2149760T3 ES 91906073 T ES91906073 T ES 91906073T ES 91906073 T ES91906073 T ES 91906073T ES 2149760 T3 ES2149760 T3 ES 2149760T3
Authority
ES
Spain
Prior art keywords
cells
fetal cells
maternal
cell surface
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91906073T
Other languages
English (en)
Inventor
Malcolm J Simons
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetype AG
Original Assignee
Genetype AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetype AG filed Critical Genetype AG
Application granted granted Critical
Publication of ES2149760T3 publication Critical patent/ES2149760T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/824—Immunological separation techniques

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • External Artificial Organs (AREA)

Abstract

LA PRESENTE INVENCION PRESENTA UN METODO PARA RECUPERAR DE MANERA SELECTIVA CELULAS FETALES DE UNA MUESTRA DE SANGRE MATERNA. EL METODO SE LLEVA A CABO EN UNA MUESTRA DE SANGRE DE UNA MUJER EMBARAZADA QUE TENGA UN PRIMER Y UN SEGUNDO ANTIGENO DE LA SUPERFICIE DE CELULAS EXPRESADOS POR UN PRIMER ALELO DE UNA POSICION GENETICA POLIMORFICO Y UN SEGUNDO ALELO DE UNA POSICION GENETICA POLIMORFICA. EL METODO SEPARA LAS CELULAS MATERNALES Y FETALES BASANDOSE EN LAS REACTIVIDADES DIFERENCIALES DE LAS CELULAS A ANTICUERPOS PARA ANTIGENOS DE LA SUPERFICIE DE CELULAS POLIMORFICOS, PARTICULARMENTE LOS ANTIGENOS DE HLA. EN PARTICULAR, LAS CELULAS MATERNAS Y FETALES SE SEPARAN EN BASE A LA NO REACTIVIDAD DE LAS CELULAS FETALES O UN ANTICUERPO ESPECIFICO PARA UN ANTIGENO DE LA SUPERFICIE DE LAS CELULAS CODIFICADO POR UN ALELO MATERNAL NO TRANSMITIDO. EL METODO SE PUEDE LLEVAR A CABO UTILIZANDO UN ANTICUERPO UNIDO DE FASE SOLIDA Y RECUPERANDO LAS CELULAS NO ENLAZADAS O UTILIZANDO UN ANTICUERPO MARCADO FLUORESCENTE Y RECUPERANDO LAS CELULAS NO MARCADAS CON EL CLASIFICADOR DE CELULAS ACTIVADO FLUORESCENTE. EN UNA PUESTA EN PRACTICA PREFERENTE DE LA INVENCION, LAS CELULAS SE PONEN TAMBIEN EN CONTACTO CON UN SEGUNDO ANTICUERPO ESPECIFICO PARA EL SEGUNDO ANTIGENO DE LA SUPERFICIE DE LAS CELULAS. LAS CELULAS FETALES SE SEPARAN EN BASE A SU REACCION CON, COMO MUCHO, UNO DE LOS ANTICUERPOS.
ES91906073T 1990-03-27 1991-03-27 Procedimiento para la recuperacion de celulas fetales. Expired - Lifetime ES2149760T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/499,932 US5153117A (en) 1990-03-27 1990-03-27 Fetal cell recovery method

Publications (1)

Publication Number Publication Date
ES2149760T3 true ES2149760T3 (es) 2000-11-16

Family

ID=23987348

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91906073T Expired - Lifetime ES2149760T3 (es) 1990-03-27 1991-03-27 Procedimiento para la recuperacion de celulas fetales.

Country Status (16)

Country Link
US (2) US5153117A (es)
EP (1) EP0521909B1 (es)
JP (1) JP2965699B2 (es)
AT (1) ATE194166T1 (es)
AU (1) AU649027B2 (es)
CA (1) CA2059554C (es)
DE (1) DE69132269T2 (es)
DK (1) DK0521909T3 (es)
ES (1) ES2149760T3 (es)
GR (1) GR3034487T3 (es)
IE (1) IE910996A1 (es)
IL (1) IL97677A (es)
NZ (1) NZ237589A (es)
SG (1) SG79188A1 (es)
WO (1) WO1991014768A1 (es)
ZA (1) ZA912317B (es)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU658132B2 (en) * 1989-11-13 1995-04-06 Children's Medical Center Corporation Non-invasive method for isolation and detection of fetal DNA
US5153117A (en) * 1990-03-27 1992-10-06 Genetype A.G. Fetal cell recovery method
US5627029A (en) * 1991-05-03 1997-05-06 Genzyme Corporation Method for obtaining informative cells
EP0635067A1 (en) * 1992-04-09 1995-01-25 Ig Laboratories Inc. Probes for detecting common liveborn chromosomal aneuploidies
US5629147A (en) * 1992-07-17 1997-05-13 Aprogenex, Inc. Enriching and identifying fetal cells in maternal blood for in situ hybridization
WO1994002646A1 (en) * 1992-07-17 1994-02-03 Aprogenex Inc. Enriching and identyfying fetal cells in maternal blood for in situ hybridization
US5275933A (en) * 1992-09-25 1994-01-04 The Board Of Trustees Of The Leland Stanford Junior University Triple gradient process for recovering nucleated fetal cells from maternal blood
EP0690927A4 (en) * 1993-01-06 2002-02-13 Boehringer Mannheim Corp DETECTING NON-LIVING CELLS BY FLUORESCENCE
US5457024A (en) * 1993-01-22 1995-10-10 Aprogenex, Inc. Isolation of fetal erythrocytes
AU7921194A (en) * 1993-09-27 1995-04-18 Oncor, Inc. Methods for detecting and analyzing individual rare cells in a population
US6136540A (en) * 1994-10-03 2000-10-24 Ikonisys Inc. Automated fluorescence in situ hybridization detection of genetic abnormalities
US5352613A (en) * 1993-10-07 1994-10-04 Tafas Triantafillos P Cytological screening method
GB9422504D0 (en) * 1994-11-08 1995-01-04 Robertson Patricia M B Blood testing
US5750339A (en) * 1994-11-30 1998-05-12 Thomas Jefferson University Methods for identifying fetal cells
US5639669A (en) * 1995-06-07 1997-06-17 Ledley; Robert Separation of fetal cells from maternal blood
CA2251186A1 (en) * 1996-04-05 1997-10-16 The Johns Hopkins University A method of enriching rare cells
US6060240A (en) * 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
JP4323571B2 (ja) 1997-01-31 2009-09-02 エックスワイ， インコーポレイテッド 光学装置
EP0974056B1 (en) * 1997-03-08 2005-11-02 The University of Dundee Prenatal diagnostic methods in vitro
US6890755B1 (en) * 1997-12-08 2005-05-10 The Trustees Of Columbia University In The City Of New York Recovery of fetal cells from maternal blood using chaotic advection
US6149867A (en) * 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6210889B1 (en) * 1998-01-28 2001-04-03 The Universite Laval Method for enrichment of fetal cells from maternal blood and use of same in determination of fetal sex and detection of chromosomal abnormalities
US6733967B1 (en) 1998-04-21 2004-05-11 Interleukin Genetics, Inc. Fetal testing for prediction of low birth weight
EP1100534B1 (en) 1998-07-30 2008-01-16 XY, Inc. Equine system for non-surgical artificial insemination
JP2002541438A (ja) * 1999-02-18 2002-12-03 バイオ−ヴィユー リミテッド 混合細胞個体群内の希少な細胞型の同定及び分析用システム及び方法
WO2000071987A2 (en) * 1999-05-25 2000-11-30 John Philip Isolation and culturing of fetal cells
WO2001033228A2 (en) * 1999-11-03 2001-05-10 Oncotech, Inc. Cancer diagnosis employing cell-sorting and gene-profiles
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
AU2001277635A1 (en) * 2000-03-14 2001-10-08 Exiqon A/S New methods for separation and isolation of subpopulations of cells in biological samples
NZ545311A (en) 2000-05-09 2008-03-28 Xy Inc Flow cytometer for high purity X-chromosome bearing and Y-chromosome bearing populations of spermatozoa
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
CA2822983C (en) 2000-11-29 2017-05-09 Xy, Llc System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
EP1405058A4 (en) * 2001-03-19 2007-07-04 Ikonisys Inc SYSTEM AND METHOD FOR INCREASING THE CONTRAST OF AN IMAGE PRODUCED BY AN EPIFLUORESCENT MICROSCOPE
US20040214314A1 (en) * 2001-11-02 2004-10-28 Friedrich Srienc High throughput bioreactor
EP1451304A4 (en) * 2001-11-07 2006-09-20 Bioview Ltd KITS AND METHODS FOR PREPARING CELLULAR SAMPLES OPTIMIZED FOR DUAL COLORING
JP2006523082A (ja) * 2002-03-01 2006-10-12 ラブジェン， インコーポレイテッド ゲノム内の変異の迅速分析
US6977162B2 (en) * 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
US7442506B2 (en) 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
US20070178478A1 (en) * 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
EP1532453B1 (en) * 2002-05-31 2013-08-21 Genetic Technologies Limited Maternal antibodies as fetal cell markers to identify and enrich fetal cells from maternal blood
EP1533616A4 (en) * 2002-06-07 2007-01-17 Towa Kagaku Co Ltd DETECTION KIT, BIOLOGICAL TEST PLATE USABLE WITH THE SAME, DETECTION METHOD, EVALUATION METHOD, POLYCLONAL ANTIBODY OF FROG VITELLOGENIN AND PROCESS FOR THE PRODUCTION THEREOF
AU2003243475A1 (en) * 2002-06-13 2003-12-31 New York University Early noninvasive prenatal test for aneuploidies and heritable conditions
BRPI0313163B1 (pt) 2002-08-01 2015-11-17 Univ Colorado State sistema de separação de células espermáticas a baixa pressão
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
AU2003265471B2 (en) 2002-08-15 2009-08-06 Xy, Llc. High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US8895298B2 (en) 2002-09-27 2014-11-25 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
ES2784011T3 (es) 2002-10-16 2020-09-21 Streck Inc Procedimiento y dispositivo para recoger y preservar las células para su análisis
WO2004078999A1 (en) * 2003-03-05 2004-09-16 Genetic Technologies Limited Identification of fetal dna and fetal cell markers in maternal plasma or serum
DK2305173T3 (en) 2003-03-28 2016-08-22 Inguran Llc Apparatus and method for providing sorted particles
US20060263829A1 (en) 2003-05-15 2006-11-23 Evans Kenneth M Efficient haploid cell sorting flow cytometer systems
AU2005229073B2 (en) 2004-03-29 2010-08-19 Inguran, Llc Sperm suspensions for use in insemination
US7833147B2 (en) 2004-07-22 2010-11-16 Inguran, LLC. Process for enriching a population of sperm cells
US7527978B2 (en) * 2004-10-07 2009-05-05 Children's Hospital & Research Center At Oakland Flow cytometry based micronucleus assays and kits
US7439062B2 (en) * 2004-12-23 2008-10-21 Biocept, Inc. Beads for capturing target cells from bodily fluid
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
EP2594631A1 (en) * 2005-04-05 2013-05-22 Cellpoint Diagnostics Devices and method for detecting circulating tumor cells and other particles
GB0509500D0 (en) * 2005-05-10 2005-06-15 Revealcyte Method of fetal cell enrichment
US20090305236A1 (en) * 2005-05-11 2009-12-10 Genetic Technologies Limited Methods of enriching fetal cells
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
CA2632859C (en) * 2005-12-02 2014-07-15 Simons Haplomics Limited Methods for gene mapping and haplotyping
US20080070792A1 (en) 2006-06-14 2008-03-20 Roland Stoughton Use of highly parallel snp genotyping for fetal diagnosis
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
GB0616045D0 (en) * 2006-08-11 2006-09-20 Univ Bristol Blood cell separation
DE102006062619B4 (de) * 2006-12-29 2012-04-26 Medion Diagnostics Ag Verfahren zur Bestimmung von minoren Zellpopulationen in heterogenen Zellpopulationen
EP2250497B1 (en) * 2008-02-18 2014-09-10 Genetic Technologies Limited Cell processing and/or enrichment methods
AU2009223122B2 (en) 2008-03-12 2014-12-11 University Of Virginia Patent Foundation Detection of polymeric analytes
US20120149587A1 (en) * 2008-03-12 2012-06-14 University Of Virginia Patent Foundation Method for detecting nucleated cells
CN102171565B (zh) 2008-08-04 2015-04-29 纳特拉公司 等位基因调用和倍性调用的方法
PT2334812T (pt) 2008-09-20 2017-03-29 Univ Leland Stanford Junior ¿diagnóstico não invasivo de aneuploidia fetal por sequenciação
US20100167271A1 (en) * 2008-12-30 2010-07-01 Streck, Inc. Method for screening blood using a preservative that may be in a substantially solid state form
US11634747B2 (en) * 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
DE202010018561U1 (de) 2009-01-21 2017-08-28 Streck Inc. Blutsammelröhrchen
EP3290530B1 (en) 2009-02-18 2020-09-02 Streck Inc. Preservation of cell-free nucleic acids
US9447467B2 (en) 2009-04-21 2016-09-20 Genetic Technologies Limited Methods for obtaining fetal genetic material
EP2473638B1 (en) 2009-09-30 2017-08-09 Natera, Inc. Methods for non-invasive prenatal ploidy calling
ES2571104T3 (es) * 2009-11-09 2016-05-24 Streck Inc Estabilización del ARN y extracción del ARN presente en células intactas dentro de una muestra de sangre
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
CA2798758C (en) 2010-05-18 2019-05-07 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
JP6328934B2 (ja) 2010-12-22 2018-05-23 ナテラ， インコーポレイテッド 非侵襲性出生前親子鑑定法
AU2011358564B9 (en) 2011-02-09 2017-07-13 Natera, Inc Methods for non-invasive prenatal ploidy calling
WO2012151391A2 (en) 2011-05-04 2012-11-08 Streck, Inc. Inactivated virus compositions and methods of preparing such compositions
ES2938048T3 (es) 2013-07-24 2023-04-04 Streck Llc Composiciones y procedimientos para estabilizar las células tumorales circulantes
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
WO2015048535A1 (en) 2013-09-27 2015-04-02 Natera, Inc. Prenatal diagnostic resting standards
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
CN106460070B (zh) 2014-04-21 2021-10-08 纳特拉公司 检测染色体片段中的突变和倍性
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
WO2018022991A1 (en) 2016-07-29 2018-02-01 Streck, Inc. Suspension composition for hematology analysis control
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675286A (en) * 1985-01-28 1987-06-23 Aspen Diagnostics, Inc. Fetal cell separation and testing
US4835098A (en) * 1985-09-04 1989-05-30 Regents Of University Of Minnesota Characterization of HLA alleles with locus-specific DNA probes
US4987086A (en) * 1987-11-30 1991-01-22 Becton, Dickinson And Company Method for analysis of subpopulations of cells
DE68928535T2 (de) * 1988-12-06 1998-04-16 Flinders Technologies Pty Ltd Isolierung von fetalen zellen aus mütterlichem blut zur ausführung von pränataler diagnostik
US5153117A (en) * 1990-03-27 1992-10-06 Genetype A.G. Fetal cell recovery method

Also Published As

Publication number Publication date
ATE194166T1 (de) 2000-07-15
CA2059554C (en) 2004-06-22
IL97677A (en) 1996-07-23
NZ237589A (en) 1992-04-28
AU649027B2 (en) 1994-05-12
JP2965699B2 (ja) 1999-10-18
SG79188A1 (en) 2001-03-20
GR3034487T3 (en) 2000-12-29
EP0521909A4 (en) 1993-11-18
WO1991014768A1 (en) 1991-10-03
ZA912317B (en) 1991-12-24
EP0521909A1 (en) 1993-01-13
IE910996A1 (en) 1991-10-09
US5447842A (en) 1995-09-05
AU7471691A (en) 1991-10-21
DE69132269D1 (de) 2000-08-03
DK0521909T3 (da) 2000-10-30
DE69132269T2 (de) 2001-03-15
IL97677A0 (en) 1992-06-21
CA2059554A1 (en) 1991-09-28
EP0521909B1 (en) 2000-06-28
US5153117A (en) 1992-10-06
JPH05506144A (ja) 1993-09-16

Similar Documents

Publication Publication Date Title
ES2149760T3 (es) Procedimiento para la recuperacion de celulas fetales.
ES2112833T3 (es) Aislamiento de celulas fetales a partir de sangre materna para permitir el diagnostico prenatal.
CA2817390C (en) Enrichment and identification of fetal cells in maternal blood and ligands for such use
SE7908936L (sv) Forfarande och anordning for samtidig bestemning av ett flertal olika ligander i ett vetskeprov
ATE130437T1 (de) Immuntest und reagenzien zum nachweis von durch schwangerschaft hervorgerufenem bluthochdruck und eklampsie.
US20180015470A1 (en) Microfluidics based fetal cell detection and isolation for non-invasive prenatal testing
ATE449164T1 (de) Isolierung und anreicherung fötaler zellen
ES2177653T3 (es) Ensayo del cancer que comprende la utilizacion de una sonda derivada del gen h19.
CN101782585A (zh) 肺癌组织蛋白印迹膜片及其制备方法
CN111733288B (zh) 核酸检测的方法及其装置和在covid-19检测中的应用
CN111304153A (zh) 一种分离滋养层细胞的方法
ES2194979T3 (es) Antigeno de chlamydia pneumoniae, procedimiento para su obtencion, metodo para analizar anticuerpos anti-chlamydia pneumoniae utilizandolo, y reactivo para analizar anticuerpos anti-chlamydia pneumoniae.
Savion et al. Use of antibodies against the human antigen of erythroblasts for the detection of nucleated erythrocytes in the maternal circulation
AR023904A1 (es) Anticuerpos para el antigeno de las celulas dendriticas y sus usos
Wright Jr et al. Isolation of a soluble tumor-associated antigen from human renal cell carcinoma by gradient acrylamide gel electrophoresis
CN213240182U (zh) 一种用于检测双份生物样本来源同一性的快速检测试纸
De Souza et al. Retrospective study of a pioneer antenatal screening program with 8,477 pregnant women in Brazil
Dodge Histological Typing of Testis Tumours (International Histological Classification of Tumours, No. 16)
KR101486196B1 (ko) 압력을 활용한 항체 조직 침투 가속기술
Phairatana et al. Comparison of In-House Microfluidic Device and Centrifuge-Based Method Efficacy in Sperm Preparation for Assisted Reproductive Technology
Sacci et al. Serodiagnosis of New World leishmaniasis by using a genus-specific antigen in enzyme linked immunosorbent assays
CN2528018Y (zh) ToRCH蛋白质芯片
DE68917732D1 (de) Immuntestverfahren von chondrocalcin.
Roy et al. Evidence for the concentration of α2u globulin by salivary glands
Tahir Identification of Fast Moving Seminal Acid Phosphatase (SAP) in a Sexual Assault Case

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 486626

Country of ref document: ES