ES2112833T3 - Aislamiento de celulas fetales a partir de sangre materna para permitir el diagnostico prenatal. - Google Patents
Aislamiento de celulas fetales a partir de sangre materna para permitir el diagnostico prenatal.Info
- Publication number
- ES2112833T3 ES2112833T3 ES90900018T ES90900018T ES2112833T3 ES 2112833 T3 ES2112833 T3 ES 2112833T3 ES 90900018 T ES90900018 T ES 90900018T ES 90900018 T ES90900018 T ES 90900018T ES 2112833 T3 ES2112833 T3 ES 2112833T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- cells
- isolation
- maternal blood
- fetal cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
ESTA INVENCION SE REFIERE A UN METODO PARA AISLAR LAS CELULAS TROFOBLASTOS (PLACENTA) DE LA SANGRE DE UN MAMIFERO PREÑADO DE FORMA QUE PROPORCIONE EL MATERIAL DE COMIENZO ESENCIAL, LLAMADO CELULAS DERIVADO DEL FETO, PARA PERMITIR LA INFORMACION GENETICA Y/O BIOQUIMICA ACERCA DEL FETO QUE SE VA A OBTENER. EN PARTICULAR, LA INVENCION SE REFIERE A LA UTILIZACION DE ANTICUERPOS MONOCLONICOS ESPECIFICOS PARA LOS MARCADORES DE LAS PROTEINAS DE LAS MEMBRANAS EN LOS TROFOBLASTOS DE LOS MAMIFEROS PARA AISLAR LAS CELULAS TROFOBLASTOS DE LA SANGRE MATERNA. ESTAS CELULAS PUEDEN UTILIZARSE ENTONCES PARA OBTENER INFORMACION GENETICA Y/O BIOQUIMICA A PRINCIPIOS DEL EMBARAZO. LA INVENCION ACTUAL ES PARTICULARMENTE IMPORTANTE PARA DETECTAR ANORMALIDADES DE LOS FETOS HUMANOS .
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPJ182488 | 1988-12-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2112833T3 true ES2112833T3 (es) | 1998-04-16 |
Family
ID=3773565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90900018T Expired - Lifetime ES2112833T3 (es) | 1988-12-06 | 1989-11-29 | Aislamiento de celulas fetales a partir de sangre materna para permitir el diagnostico prenatal. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5503981A (es) |
EP (1) | EP0447424B1 (es) |
JP (1) | JP2935741B2 (es) |
CN (1) | CN1021257C (es) |
AT (1) | ATE161960T1 (es) |
CA (1) | CA2004592A1 (es) |
DE (1) | DE68928535T2 (es) |
DK (1) | DK107391A (es) |
ES (1) | ES2112833T3 (es) |
NZ (1) | NZ231621A (es) |
WO (1) | WO1990006509A1 (es) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6475720B1 (en) | 1986-01-16 | 2002-11-05 | The Regents Of The University Of California | Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17 |
US5756696A (en) | 1986-01-16 | 1998-05-26 | Regents Of The University Of California | Compositions for chromosome-specific staining |
US6344315B1 (en) | 1986-01-16 | 2002-02-05 | The Regents Of The University Of California | Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17 |
US5447841A (en) | 1986-01-16 | 1995-09-05 | The Regents Of The Univ. Of California | Methods for chromosome-specific staining |
US6872817B1 (en) | 1986-01-16 | 2005-03-29 | The Regents Of The Univ. Of California | Method of staining target interphase chromosomal DNA |
US7115709B1 (en) * | 1986-01-16 | 2006-10-03 | The Regents Of The University Of California | Methods of staining target chromosomal DNA employing high complexity nucleic acid probes |
ATE163971T1 (de) * | 1989-08-03 | 1998-03-15 | Univ California | Verfahren zur isolierung von fetalen zytotrophoblastzellen |
EP0500727B1 (en) * | 1989-11-13 | 1998-01-21 | Children's Medical Center Corporation | Non-invasive method for isolation and detection of fetal dna |
US5641628A (en) * | 1989-11-13 | 1997-06-24 | Children's Medical Center Corporation | Non-invasive method for isolation and detection of fetal DNA |
US5153117A (en) * | 1990-03-27 | 1992-10-06 | Genetype A.G. | Fetal cell recovery method |
FR2682481A1 (fr) * | 1991-10-11 | 1993-04-16 | Saint Cy Scp | Procede d'obtention de cellules trophoblastiques d'un fóoetus. |
EP0610359A1 (en) * | 1991-10-23 | 1994-08-17 | Cellpro Incorporated | A method for enriching fetal progenitor cells from maternal blood |
FR2685777A1 (fr) * | 1991-12-31 | 1993-07-02 | Bertin & Cie | Procede de depistage prenatal d'anomalies fóoetales et procede de depistage prenatal du sexe. |
DE4222573C1 (es) * | 1992-05-16 | 1993-08-12 | Dorothee Dr. 4400 Muenster De Ahlert | |
US5457024A (en) * | 1993-01-22 | 1995-10-10 | Aprogenex, Inc. | Isolation of fetal erythrocytes |
US5662813A (en) | 1994-10-21 | 1997-09-02 | Bioseparations, Inc. | Method for separation of nucleated fetal erythrocytes from maternal blood samples |
US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
US5801145A (en) * | 1996-02-09 | 1998-09-01 | Ontario Cancer Institute | Method for selectively purging CD77+ cells from bone marrow |
AUPO931997A0 (en) * | 1997-09-22 | 1997-10-09 | Flinders Technologies Pty Ltd | Enrichment and identification of trophoblast cells in maternal peripheral blood |
US6221596B1 (en) | 1999-05-17 | 2001-04-24 | Motobit Ltd. | System and method for identifying and isolating rare cells from a mixed population of cells |
WO2001007911A2 (en) * | 1999-07-21 | 2001-02-01 | Britta Christensen | A novel method for the improved isolation of a target cell population |
DE19964044C2 (de) * | 1999-12-30 | 2001-11-22 | Frank Hans Georg | Verfahren zur Identifizierung von Substanzen, die Säugetier-Epitope nachahmen |
IL150216A0 (en) * | 1999-12-30 | 2002-12-01 | Hans Georg Frank | Method for identifying substances which mimic mammal epitopes |
US20020045196A1 (en) * | 2000-05-12 | 2002-04-18 | Walt Mahoney | Methods of isolating trophoblast cells from maternal blood |
US20050100951A1 (en) * | 2000-10-26 | 2005-05-12 | Biocept, Inc. | 3D format biochips and method of use |
FR2824144B1 (fr) | 2001-04-30 | 2004-09-17 | Metagenex S A R L | Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel |
WO2003102595A1 (en) * | 2002-05-31 | 2003-12-11 | Genetype Pty Ltd | Maternal antibodies as fetal cell markers to identify and enrich fetal cells from maternal blood |
EP2359689B1 (en) | 2002-09-27 | 2015-08-26 | The General Hospital Corporation | Microfluidic device for cell separation and use thereof |
AU2004217872B2 (en) * | 2003-03-05 | 2010-03-25 | Genetic Technologies Limited | Identification of fetal DNA and fetal cell markers in maternal plasma or serum |
US20050181429A1 (en) * | 2003-04-03 | 2005-08-18 | Monaliza Medical Ltd. | Non-invasive prenatal genetic diagnosis using transcervical cells |
US20040197832A1 (en) * | 2003-04-03 | 2004-10-07 | Mor Research Applications Ltd. | Non-invasive prenatal genetic diagnosis using transcervical cells |
EP1689884A4 (en) * | 2003-10-08 | 2007-04-04 | Univ Boston | METHODS OF PRENATAL DIAGNOSIS OF CHROMOSOMIC ANOMALIES |
US7439062B2 (en) * | 2004-12-23 | 2008-10-21 | Biocept, Inc. | Beads for capturing target cells from bodily fluid |
FR2880897B1 (fr) | 2005-01-18 | 2010-12-17 | Inst Nat Sante Rech Med | Methode de detection, non invasive, prenatale, in vitro de l'etat sain normal, de l'etat de porteur sain ou de l'etat de porteur malade de la mucoviscidose |
US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US8372584B2 (en) | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
US20080070792A1 (en) | 2006-06-14 | 2008-03-20 | Roland Stoughton | Use of highly parallel snp genotyping for fetal diagnosis |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
WO2008132753A2 (en) | 2007-05-01 | 2008-11-06 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods and kits for detecting fetal cells in the maternal blood |
EP2250497B1 (en) * | 2008-02-18 | 2014-09-10 | Genetic Technologies Limited | Cell processing and/or enrichment methods |
ES2620012T3 (es) | 2008-09-20 | 2017-06-27 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnóstico no invasivo de la aneuploidia fetal por secuenciación |
SG175282A1 (en) | 2009-04-21 | 2011-11-28 | Genetic Technologies Ltd | Methods for obtaining fetal genetic material |
WO2010150259A1 (en) * | 2009-06-24 | 2010-12-29 | Fund For Medical Research Development Of Infrastructure And Health Services -Rambam Medical Center | Methods and kits for isolating placental derived microparticles and use of same for diagnosis of fetal disorders |
CN101935700A (zh) * | 2010-07-15 | 2011-01-05 | 浙江大学 | 鉴定绵羊早期胚胎性别的牙釉蛋白基因引物及其应用 |
WO2013192620A1 (en) | 2012-06-22 | 2013-12-27 | Quantrx Biomedical Corporation | Method for obtaining fetal cells and fetal cellular components |
CN103230416A (zh) * | 2013-04-16 | 2013-08-07 | 中国人民解放军第三军医大学第三附属医院 | 一种小鼠合体滋养细胞微绒毛膜的制备方法及其应用 |
CN107367618B (zh) * | 2014-10-10 | 2020-02-14 | 韦恩州立大学 | 与胎儿绒毛外滋养层细胞测定有关的方法和组合物 |
RU2695356C1 (ru) * | 2018-11-14 | 2019-07-23 | Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования "Российская медицинская академия непрерывного профессионального образования" Министерства здравоохранения Российской Федерации (ФГБОУ ДПО РМАНПО Минздрава России) | Способ прогнозирования состояния плода при преждевременном разрыве плодных оболочек с 24 до 33 недель беременности |
CN112980779B (zh) * | 2021-05-20 | 2021-08-24 | 广州凯普医药科技有限公司 | 一种从孕妇宫颈脱落细胞中分离胎盘滋养层细胞的方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU647741B2 (en) * | 1989-12-01 | 1994-03-31 | Regents Of The University Of California, The | Methods and compositions for chromosome-specific staining |
-
1989
- 1989-11-29 AT AT90900018T patent/ATE161960T1/de not_active IP Right Cessation
- 1989-11-29 EP EP90900018A patent/EP0447424B1/en not_active Expired - Lifetime
- 1989-11-29 JP JP2500105A patent/JP2935741B2/ja not_active Expired - Lifetime
- 1989-11-29 WO PCT/AU1989/000517 patent/WO1990006509A1/en active IP Right Grant
- 1989-11-29 US US07/700,139 patent/US5503981A/en not_active Expired - Fee Related
- 1989-11-29 ES ES90900018T patent/ES2112833T3/es not_active Expired - Lifetime
- 1989-11-29 DE DE68928535T patent/DE68928535T2/de not_active Expired - Fee Related
- 1989-12-04 NZ NZ231621A patent/NZ231621A/en unknown
- 1989-12-05 CA CA002004592A patent/CA2004592A1/en not_active Abandoned
- 1989-12-06 CN CN89109789A patent/CN1021257C/zh not_active Expired - Fee Related
-
1991
- 1991-06-06 DK DK107391A patent/DK107391A/da unknown
Also Published As
Publication number | Publication date |
---|---|
CN1043788A (zh) | 1990-07-11 |
ATE161960T1 (de) | 1998-01-15 |
EP0447424A1 (en) | 1991-09-25 |
JPH04502060A (ja) | 1992-04-09 |
US5503981A (en) | 1996-04-02 |
CA2004592A1 (en) | 1990-06-06 |
NZ231621A (en) | 1992-11-25 |
JP2935741B2 (ja) | 1999-08-16 |
DE68928535T2 (de) | 1998-04-16 |
DK107391D0 (da) | 1991-06-06 |
EP0447424A4 (en) | 1992-06-24 |
CN1021257C (zh) | 1993-06-16 |
DK107391A (da) | 1991-07-31 |
WO1990006509A1 (en) | 1990-06-14 |
DE68928535D1 (de) | 1998-02-12 |
EP0447424B1 (en) | 1998-01-07 |
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Legal Events
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