ES2140547T3 - Procedimiento de deshalogenacion selectiva. - Google Patents

Procedimiento de deshalogenacion selectiva.

Info

Publication number
ES2140547T3
ES2140547T3 ES94923063T ES94923063T ES2140547T3 ES 2140547 T3 ES2140547 T3 ES 2140547T3 ES 94923063 T ES94923063 T ES 94923063T ES 94923063 T ES94923063 T ES 94923063T ES 2140547 T3 ES2140547 T3 ES 2140547T3
Authority
ES
Spain
Prior art keywords
selective dehalogenation
procedure
general formula
dehalogenation procedure
compound represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94923063T
Other languages
English (en)
Inventor
Toshifumi Akiba
Takanobu Ikeya
Hirofumi Kawanishi
Yusuke Yukimoto
Shinji Kamihara
Tsutomu Ebata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2140547T3 publication Critical patent/ES2140547T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/317—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

SE PRESENTA UN PROCESO ADECUADO PARA PRODUCIR UN COMPUESTO REPRESENTADO POR LA FORMULA (II) MEDIANTE HIDROGENOLISIS CATALITICA DE UN COMPUESTO REPRESENTADO POR LA FORMULA GENERAL (I) O (III) EN LA PRESENCIA DE UNA BASE, EN DONDE R REPRESENTA HIDROGENO O ALQUILO C{SUB,1-4}; Y X REPRESENTA CLORO O BROMO. EL COMPUESTO OBTENIDO PUEDE UTILIZARSE COMO PRODUCTO INTERMEDIO PARA LA PRODUCCION DE MEDICAMENTOS.
ES94923063T 1993-08-05 1994-08-03 Procedimiento de deshalogenacion selectiva. Expired - Lifetime ES2140547T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19442393 1993-08-05

Publications (1)

Publication Number Publication Date
ES2140547T3 true ES2140547T3 (es) 2000-03-01

Family

ID=16324364

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94923063T Expired - Lifetime ES2140547T3 (es) 1993-08-05 1994-08-03 Procedimiento de deshalogenacion selectiva.

Country Status (8)

Country Link
US (1) US5780669A (es)
EP (1) EP0712831B1 (es)
AT (1) ATE186292T1 (es)
DE (1) DE69421536T2 (es)
DK (1) DK0712831T3 (es)
ES (1) ES2140547T3 (es)
GR (1) GR3032474T3 (es)
WO (1) WO1995004712A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09124556A (ja) 1995-08-30 1997-05-13 Dai Ichi Seiyaku Co Ltd ハロゲン化シクロプロパン誘導体の製造方法
DE19620798A1 (de) * 1996-05-23 1997-11-27 Bayer Ag Verfahren zur Herstellung von 2-Fluor-1-cyclopropancarbonsäure und Derivaten davon durch reduktive Enthalogenierung
US6984768B2 (en) 2002-05-21 2006-01-10 Battelle Energy Alliance, Llc Method for destroying halocarbon compositions using a critical solvent
ATE488489T1 (de) * 2003-01-07 2010-12-15 Daiichi Sankyo Co Ltd Verfahren zur reduktiven deshalogenierung
JP4891068B2 (ja) * 2004-03-31 2012-03-07 第一三共株式会社 １，２−シス−２−フルオロシクロプロパン−１−カルボン酸エステル類の製造法
JP4584625B2 (ja) * 2004-05-20 2010-11-24 第一三共株式会社 １，２−シス−２−フルオロシクロプロパン−１−カルボン酸エステル類の製法
CN106316824B (zh) * 2016-08-18 2018-10-19 广州康瑞泰药业有限公司 一种合成2-氟环丙烷甲酸的新方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3824433A1 (de) * 1988-07-19 1990-01-25 Bayer Ag, 5090 Leverkusen Fluorcyclopropyl-derivate
JP3159537B2 (ja) * 1992-08-21 2001-04-23 第一製薬株式会社 ２−フルオロシクロプロパンカルボン酸の製法
JP3326215B2 (ja) * 1992-11-20 2002-09-17 第一製薬株式会社 還元的脱ハロゲン化法

Also Published As

Publication number Publication date
EP0712831A4 (en) 1996-09-25
EP0712831B1 (en) 1999-11-03
WO1995004712A1 (fr) 1995-02-16
DE69421536D1 (de) 1999-12-09
GR3032474T3 (en) 2000-05-31
DK0712831T3 (da) 2000-04-03
DE69421536T2 (de) 2000-07-06
US5780669A (en) 1998-07-14
ATE186292T1 (de) 1999-11-15
EP0712831A1 (en) 1996-05-22

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