ES2138978T3 - Procedimiento para la preparacion de (s)(+)-4,4'-(1-metil-1,2-etanodiil)-bis(2,6-piperazindiona). - Google Patents

Procedimiento para la preparacion de (s)(+)-4,4'-(1-metil-1,2-etanodiil)-bis(2,6-piperazindiona).

Info

Publication number
ES2138978T3
ES2138978T3 ES92921725T ES92921725T ES2138978T3 ES 2138978 T3 ES2138978 T3 ES 2138978T3 ES 92921725 T ES92921725 T ES 92921725T ES 92921725 T ES92921725 T ES 92921725T ES 2138978 T3 ES2138978 T3 ES 2138978T3
Authority
ES
Spain
Prior art keywords
pct
bis
methyl
piperazindiona
ethanodiyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92921725T
Other languages
English (en)
Inventor
Peter Lindsay Macdonald
Riccardo Stradi
Pierluigi Rossetto
Josephus Johannes Mar Holthuis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SICOR Societa Italiana Corticosteroidi SRL
Chiron BV
Original Assignee
SICOR Societa Italiana Corticosteroidi SRL
Chiron BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SICOR Societa Italiana Corticosteroidi SRL, Chiron BV filed Critical SICOR Societa Italiana Corticosteroidi SRL
Application granted granted Critical
Publication of ES2138978T3 publication Critical patent/ES2138978T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN PROCESO PARA LA PREPARACION DE (S) (+)-4,4''-(1-METIL-1,2ETANODIIL)-BIS(2,6-PIPERAZINDIONA) (ICRF-187) SEGUN EL CUAL SE SINTETIZA UN PRODUCTO INTERMEDIO DE ACIDO TETRAACETICO DE 1,2DIAMINOPROPANO JUNTO CON LA SAL DE UN BIOPRODUCTO Y QUE SE CARACTERIZA PORQUE SE SOMETE AL PRODUCTO INTERMEDIO DE ACIDO TETRAACETICO A UNA FORMACION EN ANILLO A MODO DE PRODUCTO BRUTO QUE TENGA UNAS CANTIDADES SUSTANCIALES DE SAL PARA ASI PRODUCIR EL ICRF187 DESEADO.
ES92921725T 1991-10-25 1992-10-22 Procedimiento para la preparacion de (s)(+)-4,4'-(1-metil-1,2-etanodiil)-bis(2,6-piperazindiona). Expired - Lifetime ES2138978T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919122677A GB9122677D0 (en) 1991-10-25 1991-10-25 Process for preparing(s)(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)

Publications (1)

Publication Number Publication Date
ES2138978T3 true ES2138978T3 (es) 2000-02-01

Family

ID=10703528

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92921725T Expired - Lifetime ES2138978T3 (es) 1991-10-25 1992-10-22 Procedimiento para la preparacion de (s)(+)-4,4'-(1-metil-1,2-etanodiil)-bis(2,6-piperazindiona).

Country Status (12)

Country Link
US (1) US5618936A (es)
EP (1) EP0611369B1 (es)
AT (1) ATE182588T1 (es)
AU (1) AU2808892A (es)
DE (1) DE69229677T2 (es)
DK (1) DK0611369T3 (es)
ES (1) ES2138978T3 (es)
GB (1) GB9122677D0 (es)
GR (1) GR3031588T3 (es)
MX (1) MX9206138A (es)
PT (1) PT101006B (es)
WO (1) WO1993008172A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT504621B1 (de) * 2006-11-24 2014-08-15 Cyathus Exquirere Pharmaforschungsgmbh Neues verfahren zur herstellung von 4,4'-(1-methyl -1,2-ethandiyl)-bis-(2,6-piperazindion)
WO2012081036A2 (en) * 2010-12-13 2012-06-21 Sequent Scientific Limited A process for preparation of 4,4'-(1-methyl-1,2-ethandiyl)-bis-(2,6-piperazinedione)
CN102675227B (zh) * 2012-06-05 2014-07-16 江苏奥赛康药业股份有限公司 一种高纯度右丙亚胺的制备方法
CN102952088B (zh) * 2012-06-26 2015-05-27 江苏奥赛康药业股份有限公司 右丙亚胺的制备方法
CZ2013171A3 (cs) * 2013-03-07 2014-04-30 Ústav organické chemie a biochemie Akademie věd ČR, v. v. i. Způsob výroby čistých bezvodých enantiomerů kyseliny 1,2-diaminopropan-N,N,N´,N´-tetraoctové
CN110804022B (zh) * 2019-11-06 2023-01-17 扬子江药业集团有限公司 一种右丙亚胺的制备方法
CN113636980B (zh) * 2020-05-11 2023-03-03 北京泰德制药股份有限公司 一种右丙亚胺的制备方法
CN114685383B (zh) * 2020-12-26 2023-09-08 四川汇宇制药股份有限公司 一种右雷佐生的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL273691A (es) * 1961-01-19 1900-01-01
GB1234935A (en) * 1967-07-03 1971-06-09 Nat Res Dev Piperazine derivatives
US3941790A (en) * 1967-07-03 1976-03-02 National Research Development Corporation Bis diketopiperazines
US4764614A (en) * 1987-03-23 1988-08-16 Monsanto Company Process for preparing (S)(+)-4,4'(methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)
US4963551A (en) * 1987-12-21 1990-10-16 Erbamont Inc. Stable lyophilized form of (S)-(+)-bis-4,4'-(1-methyl-1,2-ethanediyl)2,6-piperazinedione and solutions thereof
US4963679A (en) * 1988-02-17 1990-10-16 Erbamont, Inc. Process for preparing bis (3,5-dioxopiperazinyl) alkanes or alkenes
GB8916072D0 (en) * 1989-07-13 1989-08-31 Creighton Andrew M Pharmaceutical compositions
GB9115596D0 (en) * 1991-07-12 1991-09-04 Creighton Andrew M Pharmaceutical compositions

Also Published As

Publication number Publication date
GB9122677D0 (en) 1991-12-11
US5618936A (en) 1997-04-08
ATE182588T1 (de) 1999-08-15
EP0611369B1 (en) 1999-07-28
PT101006A (pt) 1994-02-28
MX9206138A (es) 1994-06-30
GR3031588T3 (en) 2000-01-31
DK0611369T3 (da) 2000-02-14
AU2808892A (en) 1993-05-21
PT101006B (pt) 1999-07-30
WO1993008172A1 (en) 1993-04-29
DE69229677D1 (de) 1999-09-02
DE69229677T2 (de) 2000-02-24
EP0611369A1 (en) 1994-08-24

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