ES2137620T3 - Ligandos peptidicos para la region constante de las inmunoglobulinas. - Google Patents

Ligandos peptidicos para la region constante de las inmunoglobulinas.

Info

Publication number
ES2137620T3
ES2137620T3 ES96201706T ES96201706T ES2137620T3 ES 2137620 T3 ES2137620 T3 ES 2137620T3 ES 96201706 T ES96201706 T ES 96201706T ES 96201706 T ES96201706 T ES 96201706T ES 2137620 T3 ES2137620 T3 ES 2137620T3
Authority
ES
Spain
Prior art keywords
peptidic
immunoglobulins
links
amino acid
constant region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96201706T
Other languages
English (en)
Inventor
Giorgio Fassina
Antonio Verdoliva
Menotti Ruvo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tecnogen SpA
Original Assignee
Tecnogen SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT95MI001328A external-priority patent/IT1276761B1/it
Priority claimed from IT96MI000831 external-priority patent/IT1282380B1/it
Application filed by Tecnogen SpA filed Critical Tecnogen SpA
Application granted granted Critical
Publication of ES2137620T3 publication Critical patent/ES2137620T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

UN PEPTIDO DE LA FORMULA (I) DONDE X 1 Y X 2 , DIFERENTES UNO DE OTRO, SON UN RESIDUO AMINOACIDO DE ARGININA O TIROSINA EN CONFIGURACION L O D, EN DONDE EL GRUPO HIDROXI DE TREONINA Y TIROSINA Y LA ESTRUCTURA DE GUANIDINA DE ARGININA PUEDEN SER PROTEGIDAS POR UN COMPUESTO CONVENCIONALMENTE USADO EN QUIMICA DE PEPTIDOS PARA LA PROTECCION DEL GRUPO HIDROXI Y LA ESTRUCTURA DE GUANIDINA RESPECTIVAMENTE, N ES 1,2,3,O 4, Y R,CUANDO N 2,3, O 4, ES UN GRUPO ADECUADO PARA FORMAR UN DIMERO, TRIMERO O TETRAMERO, MIENTRAS QUE N ES 1, R ES OH, UN RESIDUO DE AMINOACIDO SIMPLE, O UN CADENA PEPTIDICA QUE COMPRENDE HASTA 7 RESIDUOS DE AMINOACIDOS.
ES96201706T 1995-06-21 1996-06-19 Ligandos peptidicos para la region constante de las inmunoglobulinas. Expired - Lifetime ES2137620T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95MI001328A IT1276761B1 (it) 1995-06-21 1995-06-21 Peptidi multimerici
IT96MI000831 IT1282380B1 (it) 1996-04-29 1996-04-29 Peptide utile come ligando

Publications (1)

Publication Number Publication Date
ES2137620T3 true ES2137620T3 (es) 1999-12-16

Family

ID=26331293

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96201706T Expired - Lifetime ES2137620T3 (es) 1995-06-21 1996-06-19 Ligandos peptidicos para la region constante de las inmunoglobulinas.

Country Status (9)

Country Link
US (3) US5880259A (es)
EP (1) EP0752425B1 (es)
JP (1) JP3811524B2 (es)
CN (1) CN1183155C (es)
AT (1) ATE185147T1 (es)
CA (1) CA2179562C (es)
DE (1) DE69604454T2 (es)
DK (1) DK0752425T3 (es)
ES (1) ES2137620T3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69604454T2 (de) 1995-06-21 2000-03-02 Tecnogen Scpa Peptidliganden für die konstante Region von Immunoglobulinen
ITMI962628A1 (it) * 1996-12-16 1998-06-16 Tecnogen Scpa Composizione farmaceutica
US6600014B2 (en) 1997-03-25 2003-07-29 Kaneka Corporation Adsorbent for eliminating hepatitis C virus, adsorber, and adsorption method
US6680376B2 (en) * 2000-12-08 2004-01-20 Good Biotech Corporation Process for selectively isolating avian immunoglobulins
US6957672B2 (en) * 2001-07-25 2005-10-25 Imperial Chemical Industries Plc Method for ensuring that coating compositions have correct color
JP2008500972A (ja) * 2004-05-14 2008-01-17 キリンファーマ株式会社 免疫グロブリンの精製方法
US7651647B1 (en) 2004-07-15 2010-01-26 Pacesetter, Inc. Method for producing highly conductive battery electrodes
ITMI20041569A1 (it) 2004-07-30 2004-10-30 Tecnogen Scpa "ligandi peptidici specifici per le immunoglobuline"
US7408030B2 (en) * 2005-01-13 2008-08-05 North Carolina State University Purification of immunoglobulins using affinity chromatography and peptide ligands
ITMI20071119A1 (it) 2007-06-01 2008-12-02 Tecnogen Spa Nuovi ligandi sintetici per immunoglobuline e composizioni farmaceutiche che li comprendono
ES2774497T3 (es) 2016-06-06 2020-07-21 Univ Wien Med Procedimiento para la detección de un anticuerpo IgM específico para un flavivirus en una muestra
CN106279715A (zh) * 2016-08-30 2017-01-04 武汉大学 一种铜‑肽多孔配位聚合物及其制备方法和应用
US20220402895A1 (en) * 2019-10-23 2022-12-22 National University Of Singapore Method and System for Synthesising Compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229490A (en) * 1987-05-06 1993-07-20 The Rockefeller University Multiple antigen peptide system
US5227297A (en) * 1990-04-17 1993-07-13 Smithkline Beecham Corporation Affinity purification ligands
US5141862A (en) * 1990-04-17 1992-08-25 Smithkline Beecham Corporation Method of purifying tpa or plasminogen activator using a tripeptide of the formula: -X-Y-argininal wherein X and Y are selected from the group consisting of pro,phe,trp and tyr
DE69132567D1 (de) * 1990-10-15 2001-05-03 Tecnogen Scpa Verfahren zur Feststellung von proteolitischen Wirkungen und/oder deren Inhibitoren
GB9107434D0 (en) * 1991-04-09 1991-05-22 Medical Res Council Peptide-based assay
JPH07188283A (ja) * 1991-04-19 1995-07-25 Suetsuna Yoko 新規なトリペプチドおよびアンジオテンシン変換酵素 阻害剤
US5216126A (en) * 1991-06-19 1993-06-01 Genentech, Inc. Receptor polypeptides and their production and uses
EP0672132A1 (en) * 1992-03-03 1995-09-20 The Salk Institute For Biological Studies Receptor internalization signals
AU7563594A (en) * 1993-08-23 1995-03-21 Applied Immune Sciences, Inc. Chimeric receptor containing one igg binding domain of both protein a and protein g
DE69604454T2 (de) 1995-06-21 2000-03-02 Tecnogen Scpa Peptidliganden für die konstante Region von Immunoglobulinen

Also Published As

Publication number Publication date
EP0752425A2 (en) 1997-01-08
US6207807B1 (en) 2001-03-27
US5880259A (en) 1999-03-09
DK0752425T3 (da) 2000-04-10
JP3811524B2 (ja) 2006-08-23
JPH0920795A (ja) 1997-01-21
ATE185147T1 (de) 1999-10-15
CN1145369A (zh) 1997-03-19
DE69604454T2 (de) 2000-03-02
EP0752425B1 (en) 1999-09-29
DE69604454D1 (de) 1999-11-04
CA2179562A1 (en) 1996-12-22
US6566077B1 (en) 2003-05-20
CA2179562C (en) 2007-12-18
EP0752425A3 (en) 1997-07-09
CN1183155C (zh) 2005-01-05

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