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Priority to BG8892489ApriorityCriticalpatent/BG48514A1/en
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The derivatives are intended for use as precursors of the low calorie peptide sweetener aspartame, which is applied in the food and pharmaceutical industries. The method is cost-effective and causes no environmental pollution, and affords the precursors in a high yield. The p-substituted phenylacetylic derivatives of aspartame have the following common formula: R-CH2-CO-Asp-Phe-OMe, where R may be p-CH3-C6H4, and p-CH3O-C6H4-. According to the method, condensation of the H-Phe-OMe in the form of an oil with R-CH2-CO-Asp-OH is carried out, where R may be p-CH3-C6H4 or p-CH3O-C6H4-, in the presence of metalloproteinase derived from Bacillus megaterium.
BG8892489A1989-06-221989-06-22P- substituted phenylacetylic derivatives of aspartam and method for their preparation
BG48514A1
(en)
Derivatives of long-chain fatty alcohols and their applications, in particular as cytotrophic and cytoprotective molecules, and pharmaceutical compositions containing same