ES2136724T3 - Emulsion liofilizada, que contiene una sustancia activa. - Google Patents

Emulsion liofilizada, que contiene una sustancia activa.

Info

Publication number
ES2136724T3
ES2136724T3 ES94901750T ES94901750T ES2136724T3 ES 2136724 T3 ES2136724 T3 ES 2136724T3 ES 94901750 T ES94901750 T ES 94901750T ES 94901750 T ES94901750 T ES 94901750T ES 2136724 T3 ES2136724 T3 ES 2136724T3
Authority
ES
Spain
Prior art keywords
active substance
emulsion
freeze
freeze emulsion
redispersible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94901750T
Other languages
English (en)
Inventor
Andreas Schutz
Hans-Jurgen Mika
Frank Sievert
Bernhard Emschermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Pharma GmbH
Original Assignee
Schwarz Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schwarz Pharma AG filed Critical Schwarz Pharma AG
Application granted granted Critical
Publication of ES2136724T3 publication Critical patent/ES2136724T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Freezing, Cooling And Drying Of Foods (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

LA INVENCION SE REFIERE A UNA COMPOSICION DE EMULSION LIOFILIZADA, QUE CONTIENE SUSTANCIA ACTIVA, SIENDO REDISPERSABLE CON AGUA PARA LA OBTENCION DE LA EMULSION ORIGINAL, ASI COMO UN PROCESO PARA SU ELABORACION. LA EMULSION REDISPERSADA ES APROPIADA PARA TRATAMIENTO PARENTERAL.
ES94901750T 1992-12-24 1993-12-10 Emulsion liofilizada, que contiene una sustancia activa. Expired - Lifetime ES2136724T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4244122A DE4244122C1 (de) 1992-12-24 1992-12-24 Lyophilisierte, wirkstoffhaltige Emulsion zur intravenösen Applikation
PCT/DE1993/001188 WO1994014418A1 (de) 1992-12-24 1993-12-10 Lyopilisierte, wirkstoffhaltige emulsion

Publications (1)

Publication Number Publication Date
ES2136724T3 true ES2136724T3 (es) 1999-12-01

Family

ID=6476565

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94901750T Expired - Lifetime ES2136724T3 (es) 1992-12-24 1993-12-10 Emulsion liofilizada, que contiene una sustancia activa.

Country Status (12)

Country Link
US (2) US5612058A (es)
EP (1) EP0675709B1 (es)
JP (1) JP2944756B2 (es)
KR (1) KR100211772B1 (es)
CN (1) CN1056746C (es)
AT (1) ATE183385T1 (es)
CA (1) CA2152186C (es)
DE (3) DE4244122C1 (es)
DK (1) DK0675709T3 (es)
ES (1) ES2136724T3 (es)
GR (1) GR3031581T3 (es)
WO (1) WO1994014418A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4244122C1 (de) * 1992-12-24 1994-06-01 Sanol Arznei Schwarz Gmbh Lyophilisierte, wirkstoffhaltige Emulsion zur intravenösen Applikation
US5693337A (en) * 1994-07-13 1997-12-02 Wakamoto Pharmaceutical Co., Ltd. Stable lipid emulsion
US5977172A (en) * 1995-09-13 1999-11-02 Nippon Shinyaku Co., Ltd. PGE1 -containing-freeze dried preparation and process for the production thereof
KR100195348B1 (ko) * 1996-10-31 1999-06-15 장용택 안정한 프로스타글란딘 e1-함유 주사제 조성물
US20030206862A1 (en) * 1998-02-07 2003-11-06 Thomas Gieselmann Contrast medium based on polyoxyethylene-660-12-hydroxystearate and anionic phospholipids
EP1100549B1 (en) * 1998-07-30 2007-03-07 Point Biomedical Corporation A novel excipient for the lyophilization of aqueous suspensions of microparticles
KR20010100194A (ko) * 2000-03-13 2001-11-14 박호군 여러 가지 물질의 가용화용 조성물과 제형 및 그들의제조방법
CN100362993C (zh) * 2005-01-07 2008-01-23 四川思达康药业有限公司 一种丹参酮乳剂及其制备方法
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
DE102008015366A1 (de) 2008-03-20 2009-09-24 Merck Patent Gmbh Lyophilisierte Nanoemulsion
ES2385995B2 (es) * 2011-01-10 2013-05-21 Universidade De Santiago De Compostela Nanocápsulas con cubierta polimérica

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2561916B1 (fr) * 1984-03-30 1987-12-11 Lafon Labor Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau
JPS60239417A (ja) * 1984-05-15 1985-11-28 Sankyo Co Ltd エマルシヨン凍結乾燥製剤の製法
IL78930A0 (en) * 1985-07-29 1986-09-30 Abbott Lab Lyophilized emulsion compositions for parenteral administration
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
ES2084698T5 (es) * 1989-05-04 2005-03-01 Southern Research Institute Procedimiento de encapsulacion.
CA2095627C (en) * 1990-11-06 1999-01-05 Junzo Seki Stable lyophilized fatty emulsions and a process for the production thereof
WO1992017162A1 (en) 1991-04-05 1992-10-15 Warner-Lambert Company Lyophilized emulsion
JPH0543450A (ja) * 1991-08-09 1993-02-23 Green Cross Corp:The 凍結乾燥製剤
DE4244122C1 (de) * 1992-12-24 1994-06-01 Sanol Arznei Schwarz Gmbh Lyophilisierte, wirkstoffhaltige Emulsion zur intravenösen Applikation
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles

Also Published As

Publication number Publication date
JPH08503956A (ja) 1996-04-30
DK0675709T3 (da) 1999-12-06
KR960700040A (ko) 1996-01-19
DE59309740D1 (de) 1999-09-23
CN1056746C (zh) 2000-09-27
EP0675709A1 (de) 1995-10-11
CN1092646A (zh) 1994-09-28
JP2944756B2 (ja) 1999-09-06
CA2152186A1 (en) 1994-07-07
CA2152186C (en) 2001-12-04
US5612058A (en) 1997-03-18
WO1994014418A1 (de) 1994-07-07
US5882684A (en) 1999-03-16
KR100211772B1 (ko) 1999-08-02
ATE183385T1 (de) 1999-09-15
DE9321577U1 (de) 2000-04-13
DE4244122C1 (de) 1994-06-01
EP0675709B1 (de) 1999-08-18
GR3031581T3 (en) 2000-01-31

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Effective date: 19960129

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