ES2134376T3 - Derivados del tocoferol. - Google Patents

Derivados del tocoferol.

Info

Publication number
ES2134376T3
ES2134376T3 ES95107593T ES95107593T ES2134376T3 ES 2134376 T3 ES2134376 T3 ES 2134376T3 ES 95107593 T ES95107593 T ES 95107593T ES 95107593 T ES95107593 T ES 95107593T ES 2134376 T3 ES2134376 T3 ES 2134376T3
Authority
ES
Spain
Prior art keywords
amino acid
compound
thiol group
bonding via
tocopherol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95107593T
Other languages
English (en)
Inventor
Kazumi Ogata
Hidetoshi Nakao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senju Pharmaceutical Co Ltd
Original Assignee
Senju Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharmaceutical Co Ltd filed Critical Senju Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2134376T3 publication Critical patent/ES2134376T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SUMINISTRA UN DERIVADO DEL TOCOFEROL DE LA SIGUIENTE FORMULA (I) O UNA SAL ACEPTABLE DEL MISMO; EN DONDE R{SUB, 1} Y R{SUB, 2} SON IGUALES O DIFERENTES Y CADA UNA REPRESENTA HIDROGENO O METIL; R{SUB,3} REPRESENTA UN {AL}AMINOACIDO, UN {OE}-AMINOACIDO, O UN PEPTIDO QUE SE UNE POR MEDIO DEL TERMINAL N DEL MISMO, EXCEPTO EN EL CASO DE LA CISTEINA O DE LA GLUTATIONA QUE TIENE UN GRUPO DE TIOL, QUE SE UNEN POR MEDIO DEL GRUPO DE TIOL. EL DERIVADO DEL TOCOFEROL DE ESTA INVENCION ES UN COMPUESTO QUE ES SOLUBLE EN AGUA Y PUEDE ESPERARSE QUE SEA UTIL COMO DROGA PARA LA MEJORA DE LAS FUNCIONES CEREBRALES Y COMO DROGA ANTICATARATAS. MAS AUN, ESTE COMPUESTO ES VALIOSO COMO ABSORBENTE DE UV, COMO INGREDIENTE PARA EL CUIDADO DE LA PIEL, O COMO ESTABILIZANTE PARA OTROS INGREDIENTES COSMETICOS.
ES95107593T 1994-05-20 1995-05-18 Derivados del tocoferol. Expired - Lifetime ES2134376T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10648494 1994-05-20

Publications (1)

Publication Number Publication Date
ES2134376T3 true ES2134376T3 (es) 1999-10-01

Family

ID=14434754

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95107593T Expired - Lifetime ES2134376T3 (es) 1994-05-20 1995-05-18 Derivados del tocoferol.

Country Status (8)

Country Link
US (1) US5606080A (es)
EP (1) EP0683164B1 (es)
KR (1) KR950032165A (es)
AT (1) ATE182888T1 (es)
CA (1) CA2148148A1 (es)
DE (1) DE69511163T2 (es)
ES (1) ES2134376T3 (es)
TW (1) TW288014B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100195291B1 (ko) * 1997-07-12 1999-06-15 서경배 비이온성 비타민
US6387882B1 (en) 1997-12-24 2002-05-14 Senju Pharmaceutical Co., Ltd. Vitamin E derivatives
KR20000000840A (ko) * 1998-06-03 2000-01-15 김영대 신규한 폴리옥시프로필렌폴리옥시에틸렌 비타민 e 및 그의제조방법
US6426362B1 (en) 1999-10-08 2002-07-30 Galileo Laboratories, Inc. Formulations of tocopherols and methods of making and using them
US7034054B2 (en) * 2000-12-15 2006-04-25 Galileo Pharmaceuticals, Inc. Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols
KR100453727B1 (ko) * 2001-01-30 2004-10-20 김영대 신규한 폴리옥시프로필렌폴리옥시에틸렌 비타민 ｅ 및그의 제조방법
KR100438402B1 (ko) * 2001-05-30 2004-07-02 김영대 폴리옥시프로필렌-폴리옥시에틸렌 비타민 이를 이용한저점도 수중유형 유화 화장료
US20030144219A1 (en) 2001-11-15 2003-07-31 Phinney Stephen Dodge Formulations and methods for treatment or amelioration of inflammatory conditions
US6858227B1 (en) 2001-11-21 2005-02-22 Sonus Pharmaceuticals, Inc. Vitamin E conjugates
KR100488220B1 (ko) * 2002-05-21 2005-05-06 김영대 폴리옥시프로필렌-폴리옥시에틸렌(ｐｏｐ-ｐｏｅ) 비타민ｅ를 함유한 나노에말션 화장료 조성물 및 그의 제조방법
BRPI0415858A (pt) * 2003-10-29 2007-01-09 Sonus Pharma Inc compostos de medicamentos terapêuticos modificados por tocoferol
US20080045559A1 (en) * 2003-10-29 2008-02-21 Sonus Pharmaceuticals, Inc. Tocopherol-modified therapeutic drug compounds
US7790701B2 (en) 2006-04-19 2010-09-07 Gelest Technologies, Inc. Silicon-based tocopherol derivatives
EP3043807B1 (en) 2013-09-13 2023-11-01 BioVentures, LLC Preparation and use of a composition for prevention and mitigation of the effects of radiation
US20160324914A1 (en) 2015-05-05 2016-11-10 Tocol Pharmaceuticals, Llc Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH529746A (de) * 1968-08-01 1972-10-31 Spofa Vereinigte Pharma Werke Verfahren zur Herstellung von Chromanderivaten
JPS57175186A (en) * 1981-04-20 1982-10-28 Fujimoto Seiyaku Kk Novel vitamin e derivative and its preparation

Also Published As

Publication number Publication date
CA2148148A1 (en) 1995-11-21
DE69511163T2 (de) 1999-11-25
DE69511163D1 (de) 1999-09-09
US5606080A (en) 1997-02-25
EP0683164B1 (en) 1999-08-04
EP0683164A1 (en) 1995-11-22
TW288014B (es) 1996-10-11
KR950032165A (ko) 1995-12-20
ATE182888T1 (de) 1999-08-15

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