ES2126911T3 - Procedimiento para la preparacion de productos intermedios quirales utiles para la sintesis de agentes fungicidas. - Google Patents

Procedimiento para la preparacion de productos intermedios quirales utiles para la sintesis de agentes fungicidas.

Info

Publication number
ES2126911T3
ES2126911T3 ES95925282T ES95925282T ES2126911T3 ES 2126911 T3 ES2126911 T3 ES 2126911T3 ES 95925282 T ES95925282 T ES 95925282T ES 95925282 T ES95925282 T ES 95925282T ES 2126911 T3 ES2126911 T3 ES 2126911T3
Authority
ES
Spain
Prior art keywords
procedure
preparation
synthesis
intermediate products
products useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95925282T
Other languages
English (en)
Inventor
William Leong
Lyman H Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2126911T3 publication Critical patent/ES2126911T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO DE PREPARACION DE COMPUESTOS QUIRALES DE FORMULA (II), DONDE X{SUP,1} Y X{SUP,2} SON, INDEPENDIENTEMENTE, F O CL, E Y ES CL, BR O I, QUE COMPRENDE HACER REACCIONAR UN TRIOL DE FORMULA (VIII), DONDE X{SUP,1} Y X{SUP,2} SON COMO SE LOS DEFINIO ANTERIORMENTE, CON ACETONA, EN PRESENCIA DE UN CATALIZADOR, Y POSTERIORMENTE CON UN HALOGENO SELECCIONADO ENTRE CL{SUB,2}, BR{SUB,2} O I{SUB,2}, O NBROMOSUCCINIMIDA O N-IODOSUCCINIMIDA.
ES95925282T 1994-07-08 1995-07-05 Procedimiento para la preparacion de productos intermedios quirales utiles para la sintesis de agentes fungicidas. Expired - Lifetime ES2126911T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/272,411 US5486625A (en) 1994-07-08 1994-07-08 Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents

Publications (1)

Publication Number Publication Date
ES2126911T3 true ES2126911T3 (es) 1999-04-01

Family

ID=23039688

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95925282T Expired - Lifetime ES2126911T3 (es) 1994-07-08 1995-07-05 Procedimiento para la preparacion de productos intermedios quirales utiles para la sintesis de agentes fungicidas.

Country Status (12)

Country Link
US (1) US5486625A (es)
EP (1) EP0770075B1 (es)
JP (1) JP3856822B2 (es)
AT (1) ATE175670T1 (es)
AU (1) AU703696B2 (es)
CA (1) CA2192186C (es)
DE (1) DE69507305T2 (es)
ES (1) ES2126911T3 (es)
FI (1) FI970055A0 (es)
HU (1) HU216166B (es)
NZ (1) NZ289575A (es)
WO (1) WO1996001823A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002253440A1 (en) * 2002-04-12 2003-10-27 Ranbaxy Laboratories Limited Derivatives of 2,2,4-trisubstituted tetrahydrofuran as antifungal agents
MX342850B (es) 2010-05-19 2016-10-14 Sandoz Ag Proceso para la preparacion de triazolonas quirales.
EP2571868B1 (en) * 2010-05-19 2016-05-04 Sandoz AG Preparation of posaconazole intermediates
BR112012029228A2 (pt) * 2010-05-19 2021-08-03 Sandoz Ag processo para a preparação de um sal de cloreto de hidrogênio, sal de cloreto de hidrogênio, sal de cloreto de hidrogênio cristalino, uso de um sal e uso do processo
AU2011254656B2 (en) 2010-05-19 2015-04-16 Sandoz Ag Process for the preparation of chiral hydrazides
CN103635465A (zh) 2011-06-16 2014-03-12 桑多斯股份公司 制备手性化合物的方法
EP2746266A1 (en) * 2012-12-19 2014-06-25 Basf Se New substituted triazoles and imidazoles and their use as fungicides
MX370412B (es) 2014-12-05 2019-12-11 Pulmocide Ltd Compuesto antimicotico.
KR102653821B1 (ko) 2015-05-21 2024-04-02 풀모사이드 리미티드 항진균성 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-트리아졸-1-일)메틸)-5-(2,4-디플루오로페닐)테트라하이드로푸란-3-일)메톡시)-3-메틸페닐)피페라진-1-일)-n-(2-하이드록시사이클로헥실)벤즈아미드 또는 이의 약학적으로 허용가능한 염.
WO2023164679A1 (en) * 2022-02-28 2023-08-31 Genentech, Inc. Processes for the preparation of phenyltetrahydrofuran compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
US4791111A (en) * 1985-12-23 1988-12-13 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties
DE3609597A1 (de) * 1986-03-21 1987-10-01 Hoechst Ag 2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
DE3622791A1 (de) * 1986-07-07 1988-01-21 Heumann Pharma Gmbh & Co Neue 1,4-piperazinderivate, verfahren zu ihrer herstellung, ihre verwendung und diese verbindungen enthaltendes arzneimittel
JPH0717634B2 (ja) * 1987-11-20 1995-03-01 シェリング・コーポレーション トリ‐およびテトラ‐置換‐オキセタンおよびテトラヒドロフランおよびその中間体
JPH0253780A (ja) * 1988-08-12 1990-02-22 Kaken Pharmaceut Co Ltd Δ↑２‐１，２，４‐トリアゾリン‐５‐オン誘導体、その製造法およびそれを有効成分とする抗潰瘍剤
NZ233502A (en) * 1989-06-09 1991-11-26 Janssen Pharmaceutica Nv 4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions
US5039676A (en) * 1990-05-11 1991-08-13 Schering Corporation Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
NZ249494A (en) * 1992-03-18 1996-04-26 Janssen Pharmaceutica Nv Itraconazole and saperconazole stereoisomers; pharmaceutical compositions
CA2120932C (en) * 1992-08-11 2004-03-30 Walter Egli Transparent heat protection element
US5403937A (en) * 1993-04-30 1995-04-04 Schering Corporation Process for preparing intermediates for the synthesis of antifungal agents

Also Published As

Publication number Publication date
JP3856822B2 (ja) 2006-12-13
EP0770075B1 (en) 1999-01-13
EP0770075A1 (en) 1997-05-02
DE69507305D1 (de) 1999-02-25
CA2192186A1 (en) 1996-01-25
US5486625A (en) 1996-01-23
AU703696B2 (en) 1999-04-01
HU216166B (hu) 1999-04-28
AU2946595A (en) 1996-02-09
DE69507305T2 (de) 1999-07-01
JPH10502637A (ja) 1998-03-10
ATE175670T1 (de) 1999-01-15
NZ289575A (en) 1998-04-27
WO1996001823A1 (en) 1996-01-25
CA2192186C (en) 2007-01-23
FI970055A (fi) 1997-01-07
HUT76689A (en) 1997-10-28
FI970055A0 (fi) 1997-01-07

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