ES2123775T3 - Procedimiento para la tipificacion de hla-b por medio de iniciadores especificos y conjuntos de sondas. - Google Patents
Procedimiento para la tipificacion de hla-b por medio de iniciadores especificos y conjuntos de sondas.Info
- Publication number
- ES2123775T3 ES2123775T3 ES94909931T ES94909931T ES2123775T3 ES 2123775 T3 ES2123775 T3 ES 2123775T3 ES 94909931 T ES94909931 T ES 94909931T ES 94909931 T ES94909931 T ES 94909931T ES 2123775 T3 ES2123775 T3 ES 2123775T3
- Authority
- ES
- Spain
- Prior art keywords
- hla
- pct
- alleles
- appropriate
- zemmour
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Saccharide Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A UN METODO PARA TIPIFICAR O SUBTIPIFICAR HLA-B QUE SE CARACTERIZA POR LA SECUENCIA GCCA EN LA POSICION 30 A 33 DE EXON 2 (CON DICHA NUMERACION ESTANDO DE ACUERDO CON ZEMMOUR Y PARHAM, 1992), SUJETO A ESTAR PRESENTE EN UNA MUESTRA, CON DICHO METODO QUE COMPRENDE AL MENOS LOS SIGUIENTES PASOS: I) AMPLIFICAR EL HLA-B CON AL MENOS UN ELEMENTO PRIMARIO DE AMPLIFICACION DEL EXTREMO 5'' DE LA SIGUIENTE LISTA: 5''-AGGTATTTCTACCCGCCA-3'' (B25P) O VARIANTES DE LA SECUENCIA DEL MISMO, EN COMBINACION CON UN ELEMENTO FUNDAMENTAL DEL EXTREMO 3'' APROPIADO ESCOGIDO ENTRE LOS MISMOS QUE LOS ELEMENTOS FUNDAMENTALES ANTES DEFINIDOS DEL EXTREMO 5'', ESTANDO POSIBLEMENTE ETIQUETADOS LOS ELEMENTOS FUNDAMENTALES DE LOS EXTREMOS 5'' Y 3''; II) HIBRIDIZAR EL PRODUCTO AMPLIFICADO, SIENDO ETIQUETADO DURANTE O DESPUES DE LA AMPLIFICACION, EN CONDICIONES APROPIADAS CON UNA O MAS SONDAS ADECUADAS SELECCIONADAS ENTRE LA REGION 15 A 261 DE LA REGION EXON 2 DEL HLA-B, ESTANDO DICHA NUMERACION DE ACUERDOCON ZEMMOUR Y PARHAM, 1992, III) LAVAR EN CONDICIONES DE LAVADO APROPIADAS; IV) DETECTAR LOS HIBRIDOS FORMADOS; Y V) INGERIR EL HLA-B PRESENTA A PARTIR DEL MODELO DE HIBRIDIZACION OBSERVADO.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93400700 | 1993-03-18 | ||
| EP93400700 | 1993-03-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2123775T3 true ES2123775T3 (es) | 1999-01-16 |
| ES2123775T5 ES2123775T5 (es) | 2005-10-01 |
Family
ID=8214689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94909931T Expired - Lifetime ES2123775T5 (es) | 1993-03-18 | 1994-03-07 | Procedimiento para la tipificacion de hla-b por medio de iniciadores especificos y conjuntos de sondas. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5883238A (es) |
| EP (1) | EP0689609B2 (es) |
| JP (1) | JP4031028B2 (es) |
| AT (1) | ATE169682T1 (es) |
| AU (1) | AU688307B2 (es) |
| CA (1) | CA2158578C (es) |
| DE (1) | DE69412470T3 (es) |
| DK (1) | DK0689609T4 (es) |
| ES (1) | ES2123775T5 (es) |
| WO (1) | WO1994021818A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5550039A (en) * | 1995-03-07 | 1996-08-27 | Hoffmann-La Roche Inc. | Oligonucleotide primers for HLA class I B locus DNA typing |
| CA2213731C (en) * | 1996-02-20 | 2003-09-09 | The Perkin-Elmer Corporation | Methods and reagents for typing hla class i genes |
| EP0953650A1 (en) * | 1998-04-20 | 1999-11-03 | Innogenetics N.V. | Method for typing of HLA alleles |
| US6436642B1 (en) | 1999-04-20 | 2002-08-20 | Curagen Corporation | Method of classifying a thyroid carcinoma using differential gene expression |
| AU5062500A (en) * | 1999-04-26 | 2000-11-10 | Amersham Pharmacia Biotech Ab | Primers for identifying typing or classifying nucleic acids |
| WO2001092572A1 (fr) * | 2000-06-01 | 2001-12-06 | Nisshinbo Industries, Inc. | Ensemble et procede de determination du type de hla |
| CA2651954C (en) * | 2006-05-11 | 2014-02-25 | Academia Sinica | Hla alleles associated with adverse drug reactions and methods for detecting such |
| WO2010151599A1 (en) * | 2009-06-23 | 2010-12-29 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Human leukocyte antigen alleles associated with advanced lung diseases |
| CN102918396B (zh) | 2010-04-12 | 2016-05-11 | 中央研究院 | 利用人类白血球抗原(hla)筛检预测药物不良反应的方法 |
| KR102131293B1 (ko) * | 2018-06-29 | 2020-07-07 | 경북대학교 산학협력단 | 서열-특이적 올리고뉴클레오티드 프로브 방법에 의한 인간백혈구항원 형별 검사에서 인간백혈구항원의 최종 형별 판정 방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4835098A (en) * | 1985-09-04 | 1989-05-30 | Regents Of University Of Minnesota | Characterization of HLA alleles with locus-specific DNA probes |
| JPH0249589A (ja) * | 1988-08-11 | 1990-02-19 | Olympus Optical Co Ltd | Ｈｌａクラスｉｄｎａおよびｄｎａプローブ並びに形質転換細胞 |
| IL95501A (en) † | 1989-09-01 | 1997-04-15 | Hutchinson Fred Cancer Res | Inhibition by antibodies of lymphocyte adherence to vascular endothelium utilizing an extracellular matrix receptor-ligand interaction, and pharmaceutical compositions containing said antibodies |
| GB9002625D0 (en) * | 1990-02-06 | 1990-04-04 | Univ Singapore | Human leukocyte antigen typing |
| GB9024005D0 (en) * | 1990-11-05 | 1990-12-19 | British Bio Technology | Process for amplifying nucleic acid |
| CA2081582A1 (en) * | 1991-11-05 | 1993-05-06 | Teodorica Bugawan | Methods and reagents for hla class i dna typing |
| US5550039A (en) * | 1995-03-07 | 1996-08-27 | Hoffmann-La Roche Inc. | Oligonucleotide primers for HLA class I B locus DNA typing |
-
1994
- 1994-03-07 DK DK94909931T patent/DK0689609T4/da active
- 1994-03-07 JP JP52058094A patent/JP4031028B2/ja not_active Expired - Lifetime
- 1994-03-07 DE DE69412470T patent/DE69412470T3/de not_active Expired - Lifetime
- 1994-03-07 EP EP94909931A patent/EP0689609B2/en not_active Expired - Lifetime
- 1994-03-07 AU AU62585/94A patent/AU688307B2/en not_active Expired
- 1994-03-07 US US08/532,727 patent/US5883238A/en not_active Expired - Lifetime
- 1994-03-07 CA CA002158578A patent/CA2158578C/en not_active Expired - Lifetime
- 1994-03-07 AT AT94909931T patent/ATE169682T1/de not_active IP Right Cessation
- 1994-03-07 ES ES94909931T patent/ES2123775T5/es not_active Expired - Lifetime
- 1994-03-07 WO PCT/EP1994/000654 patent/WO1994021818A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2158578A1 (en) | 1994-09-29 |
| DE69412470D1 (de) | 1998-09-17 |
| AU6258594A (en) | 1994-10-11 |
| DK0689609T4 (da) | 2005-07-25 |
| US5883238A (en) | 1999-03-16 |
| CA2158578C (en) | 2009-05-26 |
| DE69412470T2 (de) | 1999-03-25 |
| EP0689609B1 (en) | 1998-08-12 |
| DK0689609T3 (da) | 1999-05-17 |
| AU688307B2 (en) | 1998-03-12 |
| ES2123775T5 (es) | 2005-10-01 |
| EP0689609A1 (en) | 1996-01-03 |
| WO1994021818A1 (en) | 1994-09-29 |
| EP0689609B2 (en) | 2005-04-13 |
| JP4031028B2 (ja) | 2008-01-09 |
| DE69412470T3 (de) | 2006-07-20 |
| JPH08507690A (ja) | 1996-08-20 |
| ATE169682T1 (de) | 1998-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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