ES2121757T3 - Procedimiento mejorado para la sintesis de n-3-(1h-imidazol-1-il)fenil-2-pirimidinaminas substituidas en posicion 4. - Google Patents

Procedimiento mejorado para la sintesis de n-3-(1h-imidazol-1-il)fenil-2-pirimidinaminas substituidas en posicion 4.

Info

Publication number
ES2121757T3
ES2121757T3 ES91102859T ES91102859T ES2121757T3 ES 2121757 T3 ES2121757 T3 ES 2121757T3 ES 91102859 T ES91102859 T ES 91102859T ES 91102859 T ES91102859 T ES 91102859T ES 2121757 T3 ES2121757 T3 ES 2121757T3
Authority
ES
Spain
Prior art keywords
imidazol
substituted
phenyl
pirimidinamines
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91102859T
Other languages
English (en)
Inventor
William Dennis Dean
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ES2121757T3 publication Critical patent/ES2121757T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)

Abstract

LA INVENCION PRESENTA UN NUEVO PROCESO PARA PRODUCIR COMPUESTOS DE N-[3-(IH-IMIDAZOL-1-IL-4(SUSTITUIDO-2-PIRIMIDINAMINA EN QUE EL SUSTITUYENTE ES UN GRUPO DE 2-PIRIDINILO, 3-PIRINDINILO, 4-PIRIDINILO, 2-FURANILO O 2-TIENILO. EL PROCESO CONSISTE EN LOS PASOS SIGUIENTES: (1) HACER REACCIONAR UNA 3-(IH-IMIDAZOL-1-IL)BENZAMINA CON CIANAMIDA Y UN ACIDO HALOGENO AL TIEMPO QUE SE CONTROLA EL PH DE LA REACCION ENTRE PH DE UNOS 2 A UNOS 3,5 Y RECUPERAR UN HALOGENURO DE GUANIDINA DE [3-(IH -IMIDAZOL-1-IL)-FENILO] Y (2) HACER REACCIONAR EL HALOGENURO DE GUANIDINA DE [3-(IH-IMIDAZOL-1-IL)FENILO] ASI RECUPERADO CON UNA 3-DIMETILAMINO-1-(SUSTITUIDO-2-PROPER-1-ONA APROPIADAMENTE SUSTITUIDA Y UNA BASE A UN PH DE UNOS 10,5 A UNOS 11,5 Y RECUPERAR EL COMPUESTO DE N-[3-(IH-IMIDAZOL-1-IL)PENIL-4-(SUSTITUIDO)-2-PIRIMIDAMINA ASI PRODUCIDO . EL NUEVO PROCESO PROPORCIONA UN RENDIMIENTO Y PUREZA MEJORADAS SI SE ADHIERE A LOS VALORES DE PH CRUCIALES EXPUESTOS.
ES91102859T 1990-04-25 1991-02-27 Procedimiento mejorado para la sintesis de n-3-(1h-imidazol-1-il)fenil-2-pirimidinaminas substituidas en posicion 4. Expired - Lifetime ES2121757T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/514,455 US5064963A (en) 1990-04-25 1990-04-25 Process for the synthesis of n-(3-(1h-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines

Publications (1)

Publication Number Publication Date
ES2121757T3 true ES2121757T3 (es) 1998-12-16

Family

ID=24047219

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91102859T Expired - Lifetime ES2121757T3 (es) 1990-04-25 1991-02-27 Procedimiento mejorado para la sintesis de n-3-(1h-imidazol-1-il)fenil-2-pirimidinaminas substituidas en posicion 4.

Country Status (19)

Country Link
US (1) US5064963A (es)
EP (1) EP0453731B1 (es)
JP (1) JPH04225975A (es)
KR (1) KR0168679B1 (es)
AT (1) ATE170184T1 (es)
AU (1) AU630849B2 (es)
CA (1) CA2041031A1 (es)
DE (1) DE69130029T2 (es)
DK (1) DK0453731T3 (es)
ES (1) ES2121757T3 (es)
FI (1) FI100533B (es)
GR (1) GR3027762T3 (es)
HU (1) HU211774B (es)
IE (1) IE911366A1 (es)
NO (1) NO177567C (es)
NZ (1) NZ237870A (es)
SG (1) SG47565A1 (es)
TW (1) TW215087B (es)
ZA (1) ZA913092B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521184A (en) * 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
US5516775A (en) * 1992-08-31 1996-05-14 Ciba-Geigy Corporation Further use of pyrimidine derivatives
BRPI9909191B8 (pt) * 1998-03-27 2021-07-06 Janssen Pharmaceutica Nv derivados de pirimidina inibidores do hiv, seu uso e composição farmacêutica que os compreende
PT1225874E (pt) 1999-09-24 2006-06-30 Janssen Pharmaceutica Nv Composicoes antivirais.
CA2628474A1 (en) * 2005-11-03 2007-05-10 Sgx Pharmaceuticals, Inc. Pyrimidinyl-thiophene kinase modulators
KR20090130345A (ko) * 2007-05-04 2009-12-22 아이알엠 엘엘씨 Ｃ-ｋｉｔ 및 ｐｄｇｆｒ 키나제 억제제로서의 화합물 및 조성물
WO2013192125A1 (en) * 2012-06-20 2013-12-27 Merck Sharp & Dohme Corp. Pyrazolyl derivatives as syk inhibitors
US9487504B2 (en) 2012-06-20 2016-11-08 Merck Sharp & Dohme Corp. Imidazolyl analogs as syk inhibitors
CN110330447B (zh) * 2019-07-16 2022-04-15 北京赛升药业股份有限公司 一种甲磺酸萘莫司他中间体的制备方法及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5319479A (en) * 1978-12-22 1980-06-26 Ici Australia Limited Pyrimidinyl amino phenoxy carboxylate derivatives
EP0164204A1 (en) * 1984-05-12 1985-12-11 FISONS plc Novel pharmaceutically useful pyrimidines
US4788195A (en) * 1986-01-13 1988-11-29 American Cyanamid Company 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines

Also Published As

Publication number Publication date
EP0453731B1 (en) 1998-08-26
SG47565A1 (en) 1998-04-17
DK0453731T3 (da) 1999-02-15
HU211774B (en) 1995-12-28
NO177567C (no) 1995-10-11
NO911632D0 (no) 1991-04-24
CA2041031A1 (en) 1991-10-26
JPH04225975A (ja) 1992-08-14
FI911983A0 (fi) 1991-04-24
KR910018375A (ko) 1991-11-30
GR3027762T3 (en) 1998-11-30
FI911983A (fi) 1991-10-26
EP0453731A3 (en) 1992-09-02
FI100533B (fi) 1997-12-31
EP0453731A2 (en) 1991-10-30
NO911632L (no) 1991-10-28
ZA913092B (en) 1992-02-26
DE69130029T2 (de) 1999-02-18
KR0168679B1 (ko) 1999-01-15
IE911366A1 (en) 1991-11-06
US5064963A (en) 1991-11-12
DE69130029D1 (de) 1998-10-01
HUT57719A (en) 1991-12-30
AU630849B2 (en) 1992-11-05
NZ237870A (en) 1993-05-26
HU911373D0 (en) 1991-10-28
ATE170184T1 (de) 1998-09-15
TW215087B (es) 1993-10-21
AU7590591A (en) 1991-11-07
NO177567B (no) 1995-07-03

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