ES2115741T3 - Utilizacion de un inhibidor directo de la trombina para la preparacion de un medicamento con actividad trombolitica. - Google Patents

Utilizacion de un inhibidor directo de la trombina para la preparacion de un medicamento con actividad trombolitica.

Info

Publication number
ES2115741T3
ES2115741T3 ES93402136T ES93402136T ES2115741T3 ES 2115741 T3 ES2115741 T3 ES 2115741T3 ES 93402136 T ES93402136 T ES 93402136T ES 93402136 T ES93402136 T ES 93402136T ES 2115741 T3 ES2115741 T3 ES 2115741T3
Authority
ES
Spain
Prior art keywords
inhibitor
direct
thrombine
preparation
medicinal product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93402136T
Other languages
English (en)
Other versions
ES2115741T4 (es
Inventor
Christopher Berry
Patrice Ferrari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of ES2115741T3 publication Critical patent/ES2115741T3/es
Application granted granted Critical
Publication of ES2115741T4 publication Critical patent/ES2115741T4/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UTILIZACION DE UN INHIBIDOR DIRECTO DE LA TROMBINA PARA LA FABRICACION DE UN MEDICAMENTO CON ACTIVIDAD TROMBOLITICA.
ES93402136T 1992-09-11 1993-09-02 Utilización de un inhibidor directo de la trombina para la preparación de un medicamento con actividad trombolítica Expired - Lifetime ES2115741T4 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9210833 1992-09-11
FR9210833A FR2695562B1 (fr) 1992-09-11 1992-09-11 Utilisation d'un inhibiteur direct de la thrombine pour la fabrication d'un médicament à activité thrombolytique.

Publications (2)

Publication Number Publication Date
ES2115741T3 true ES2115741T3 (es) 1998-07-01
ES2115741T4 ES2115741T4 (es) 2012-07-04

Family

ID=9433400

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93402136T Expired - Lifetime ES2115741T4 (es) 1992-09-11 1993-09-02 Utilización de un inhibidor directo de la trombina para la preparación de un medicamento con actividad trombolítica

Country Status (18)

Country Link
US (1) US5583113A (es)
EP (1) EP0589741B1 (es)
JP (1) JPH06228007A (es)
KR (1) KR100261526B1 (es)
CN (1) CN1066961C (es)
AT (1) ATE163856T1 (es)
AU (1) AU4628193A (es)
CA (1) CA2105888C (es)
CZ (1) CZ188893A3 (es)
DE (1) DE69317343T2 (es)
DK (1) DK0589741T3 (es)
ES (1) ES2115741T4 (es)
FR (1) FR2695562B1 (es)
IL (1) IL106981A (es)
NO (1) NO306537B1 (es)
SK (1) SK96993A3 (es)
TW (1) TW284691B (es)
ZA (1) ZA936707B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830448A (en) * 1994-06-16 1998-11-03 Genentech, Inc. Compositions and methods for the treatment of tumors
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
CZ245797A3 (cs) * 1995-02-17 1998-06-17 Basf Aktiengesellschaft Derivát amidinu dipeptidu jako inhibitor thrombinu
SA96170106A (ar) * 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
KR100689923B1 (ko) 1998-01-26 2007-03-09 애보트 게엠베하 운트 콤파니 카게 트롬빈 억제제
CN101598725B (zh) * 2009-06-23 2012-07-18 南通大学附属医院 阿加曲班在血细胞和生化常规分析中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4258192A (en) * 1977-12-16 1981-03-24 Mitsubishi Chemical Industries Limited N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US4318904A (en) * 1980-04-25 1982-03-09 Research Corporation Peptide affinity labels for thrombin and other trypsin-like proteases
US4929602A (en) * 1987-11-25 1990-05-29 Scripps Clinic And Research Foundation Method of inhibiting platelet dependent arterial thrombosis
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin

Also Published As

Publication number Publication date
DE69317343T2 (de) 1998-10-08
IL106981A (en) 1999-03-12
ES2115741T4 (es) 2012-07-04
DK0589741T3 (da) 1998-12-21
NO933235D0 (no) 1993-09-10
SK96993A3 (en) 1994-08-10
AU4628193A (en) 1994-03-17
FR2695562B1 (fr) 1994-10-14
TW284691B (es) 1996-09-01
EP0589741A1 (fr) 1994-03-30
NO306537B1 (no) 1999-11-22
US5583113A (en) 1996-12-10
CZ188893A3 (en) 1994-03-16
IL106981A0 (en) 1993-12-28
JPH06228007A (ja) 1994-08-16
ZA936707B (en) 1994-03-30
NO933235L (no) 1994-03-14
DE69317343D1 (de) 1998-04-16
CN1087015A (zh) 1994-05-25
CA2105888A1 (fr) 1994-03-12
CN1066961C (zh) 2001-06-13
EP0589741B1 (fr) 1998-03-11
CA2105888C (fr) 2008-04-15
FR2695562A1 (fr) 1994-03-18
ATE163856T1 (de) 1998-03-15
KR100261526B1 (ko) 2000-07-15
KR940006600A (ko) 1994-04-25

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