ES2115722T3 - Compuestos de benzaldehido anticancerosos. - Google Patents

Compuestos de benzaldehido anticancerosos.

Info

Publication number
ES2115722T3
ES2115722T3 ES93300210T ES93300210T ES2115722T3 ES 2115722 T3 ES2115722 T3 ES 2115722T3 ES 93300210 T ES93300210 T ES 93300210T ES 93300210 T ES93300210 T ES 93300210T ES 2115722 T3 ES2115722 T3 ES 2115722T3
Authority
ES
Spain
Prior art keywords
alkyl
different
same
atoms
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93300210T
Other languages
English (en)
Inventor
Erik Olai Pettersen
Rolf Olaf Larsen
John Michael Dornish
Bernt Borretzen
Reidar Oftebro
Thomas Ramdahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Norsk Hydro ASA
Original Assignee
Norsk Hydro ASA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norsk Hydro ASA filed Critical Norsk Hydro ASA
Application granted granted Critical
Publication of ES2115722T3 publication Critical patent/ES2115722T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

NUEVOS COMPUESTOS QUE TIENEN LA FORMULA GENERAL I: EN DONDE L PUEDE SER H O D; Y PUEDE SER CN O EN DONDE A PUEDE SER H, D, ALQUILO CON DE 1 A 4 ATOMOS DE CARBONO, OR EN DONDE R ES H O ALQUILO CON DE 1 A 4 ATOMOS DE CARBONO O -CR1R2R3 EN DONDE R1, R2 Y R3 SON IGUALES O DIFERENTES Y REPRESENTAN H O ALQUILO CON DE 1 A 4 ATOMOS DE CARBONO; Z ES H, D, Y O ALQUILO CON DE 1 A 4 ATOMOS DE CARBONO, HALOGENO, NITRO, AMINO, MONOALQUILAMINO O DIALQUILAMINO EN DONDE LOS GRUPOS ALQUILO TIENEN DE 1 A 4 ATOMOS DE CARBONO O -OR EN DONDE R PUEDE SER H O ALQUILO CON DE 1 A 4 ATOMOS DE CARBONO O -CR4R5R6 EN DONDE R4, R5 Y R6 PUEDEN SER IGUALES O DIFERENTES Y PUEDEN REPRESENTAR H O F; X1 Y X2 PUEDEN SER IGUALES O DIFERENTES Y PUEDEN REPRESENTAR OR, NR1R2 O SR EN DONDE R, R1 Y R2 PUEDEN SER IGUALES O DIFERENTES Y PUEDEN REPRESENTAR ALQUILO CON DE 1 A 4 ATOMOS DE CARBONO QUE PUEDEN SER DE CADENA RECTA O RAMIFICADA Y/O PUEDEN SEGUIR SIENDO SUSTITUIDOS; O X1 Y X2 PUEDEN FORMAR JUNTOS Y CON EL ATOMO DE CARBONO AL QUE SE ENCUENTRAN ENLAZADOS UN ACETAL CICLICO, TIOACETAL, DITIANO, AMINAL, OXAZOLIDINA O TIAZOLIDINA; Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS. LOS COMPUESTOS SON UTILES COMO AGENTES CONTRA EL CANCER Y COMO AGENTES UTILES PARA EL TRATAMIENTO DE ENFERMEDADES QUE SURGEN DEBIDO A UNA PROLIFERACION DE CELULAS ANORMALMENTE ELEVADA.
ES93300210T 1992-01-21 1993-01-14 Compuestos de benzaldehido anticancerosos. Expired - Lifetime ES2115722T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929201274A GB9201274D0 (en) 1992-01-21 1992-01-21 New compounds

Publications (1)

Publication Number Publication Date
ES2115722T3 true ES2115722T3 (es) 1998-07-01

Family

ID=10708984

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93300210T Expired - Lifetime ES2115722T3 (es) 1992-01-21 1993-01-14 Compuestos de benzaldehido anticancerosos.

Country Status (10)

Country Link
US (1) US5534531A (es)
EP (1) EP0552880B1 (es)
JP (1) JPH0640989A (es)
AT (1) ATE165358T1 (es)
AU (1) AU657825B2 (es)
CA (1) CA2087656A1 (es)
DE (1) DE69318046T2 (es)
ES (1) ES2115722T3 (es)
GB (1) GB9201274D0 (es)
NO (1) NO302820B1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9400047D0 (en) * 1994-01-04 1994-03-02 Norsk Hydro As Pharmaceutical compositions
JP2990015B2 (ja) * 1994-06-20 1999-12-13 睦之 東風 抗ｈｉｖ剤
US6228868B1 (en) 1998-07-27 2001-05-08 Abbott Laboratories Oxazoline antiproliferative agents
AU5227999A (en) * 1998-07-27 2000-02-21 Abbott Laboratories Substituted oxazolines as antiproliferative agents
DE102005062175A1 (de) * 2005-12-23 2007-06-28 Henkel Kgaa Cyclische Aminale als Duftstoffe
WO2012081039A1 (en) * 2010-12-17 2012-06-21 Godavari Biorefineries Limited Molecules with anticancer activity and uses thereof
RU2015141222A (ru) * 2013-03-15 2017-04-20 ДЕУТЕРИА АГРОКЕМИКАЛС, ЭлЭлСи Обогащенные дейтерием альдегиды
US9713330B1 (en) 2013-03-15 2017-07-25 Deuteria Agrochemicals, Llc Deuterium-enriched aldehydes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO86439B (ro) * 1982-01-15 1985-03-31 Eli Lilly And Company Procedeu pentru prepararea unor derivati de acid ascorbic
JPS60139619A (ja) * 1983-12-27 1985-07-24 Mutsuyuki Kochi Ｏ−ベンジリデン−アスコルビン酸又はその塩よりなる抗腫瘍剤
US4874780A (en) * 1987-03-11 1989-10-17 Norsk Hydro A.S. Anticancer compounds
US5149820A (en) * 1987-03-11 1992-09-22 Norsk Hydro A.S. Deuterated compounds
GB9026114D0 (en) * 1990-11-30 1991-01-16 Norsk Hydro As New compounds

Also Published As

Publication number Publication date
ATE165358T1 (de) 1998-05-15
EP0552880B1 (en) 1998-04-22
JPH0640989A (ja) 1994-02-15
US5534531A (en) 1996-07-09
NO930068L (no) 1993-07-22
AU3048592A (en) 1993-07-22
NO930068D0 (no) 1993-01-11
NO302820B1 (no) 1998-04-27
CA2087656A1 (en) 1993-07-22
AU657825B2 (en) 1995-03-23
GB9201274D0 (en) 1992-03-11
DE69318046T2 (de) 1998-09-03
EP0552880A1 (en) 1993-07-28
DE69318046D1 (de) 1998-05-28

Similar Documents

Publication Publication Date Title
DE68926729T2 (de) Benzopyranderivate mit einer blutdrucksenkenden Wirkung
MX9204622A (es) Nuevos derivados de 3,5-di-tert-butil-4-hidroxifenilo, procedimiento para su preparacion y composicion farmaceutica que los contiene.
GB9026114D0 (en) New compounds
ES2115722T3 (es) Compuestos de benzaldehido anticancerosos.
DE69200394T2 (de) 3-Sulfonylamino-2-(1H)-Chinolinone und deren 7-Azaderivate als anregende Aminosäuren Antagonisten.
DE69815137D1 (de) Epoxybernsteinsäureamid-derivate
DK640889D0 (da) Fenylderivater med antidiabetisk, isaer hypoglykaemisk virkning
NO910804L (no) Substituerte beta-diketoner.
DE68926418T2 (de) S'-adenosyl-methionin-decarboxylase-Inhibitoren
KR910000133A (ko) 아민
DK498889A (da) Substituerede aromatiske forbindelser med virkning paa centralnervesystemet
ES2189323T3 (es) Procedimiento para la preparacion de 3-amino-2-oxo-pirrolidinas, productos intermedios y su utilizacion.
BR8401710A (pt) Processo para a preparacao de fenetilsulfonamidas n-sulfeniladas,composicoes praguicidas e processos para o combate as pragas e para a preparacao de composicoes
DK0658555T3 (da) Pyridazinonderivater, fremgangsmåder til fremstilling deraf samt anvendelse deraf
PT87954A (pt) Processo para a preparacao de composicoes farmaceuticas contendo derivados de dioxopiperidina, com efeito antipsicotico
ATE72240T1 (de) Azolylalkene und diese enthaltende fungizide.

Legal Events

Date Code Title Description
FA2A Application withdrawn

Effective date: 19931014

FG2A Definitive protection

Ref document number: 552880

Country of ref document: ES