ES2115656T3 - Analogos de tocoferol cardioprotectores. - Google Patents

Analogos de tocoferol cardioprotectores.

Info

Publication number
ES2115656T3
ES2115656T3 ES92402656T ES92402656T ES2115656T3 ES 2115656 T3 ES2115656 T3 ES 2115656T3 ES 92402656 T ES92402656 T ES 92402656T ES 92402656 T ES92402656 T ES 92402656T ES 2115656 T3 ES2115656 T3 ES 2115656T3
Authority
ES
Spain
Prior art keywords
cardioprotectors
tocoferol
analogs
cardioprotectoral
phosphony
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92402656T
Other languages
English (en)
Spanish (es)
Inventor
J Martin Grisar
Margaret A Petty
Frank Bolkenius
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2115656T3 publication Critical patent/ES2115656T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Inspection Of Paper Currency And Valuable Securities (AREA)
  • Cosmetics (AREA)
  • Noodles (AREA)
  • Credit Cards Or The Like (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Fire-Detection Mechanisms (AREA)
  • Photoreceptors In Electrophotography (AREA)
ES92402656T 1991-10-02 1992-09-29 Analogos de tocoferol cardioprotectores. Expired - Lifetime ES2115656T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91402630A EP0535283A1 (en) 1991-10-02 1991-10-02 Cardioprotective tocopherol analogs

Publications (1)

Publication Number Publication Date
ES2115656T3 true ES2115656T3 (es) 1998-07-01

Family

ID=8208620

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92402656T Expired - Lifetime ES2115656T3 (es) 1991-10-02 1992-09-29 Analogos de tocoferol cardioprotectores.

Country Status (17)

Country Link
EP (2) EP0535283A1 (OSRAM)
JP (1) JP3230699B2 (OSRAM)
KR (1) KR100253108B1 (OSRAM)
AT (1) ATE163421T1 (OSRAM)
AU (1) AU652077B2 (OSRAM)
CA (1) CA2079289C (OSRAM)
DE (1) DE69224501T2 (OSRAM)
DK (1) DK0536036T3 (OSRAM)
ES (1) ES2115656T3 (OSRAM)
FI (1) FI105552B (OSRAM)
GR (1) GR3026242T3 (OSRAM)
HU (1) HU215123B (OSRAM)
IL (1) IL103305A0 (OSRAM)
NO (1) NO923840L (OSRAM)
NZ (1) NZ244549A (OSRAM)
TW (1) TW224970B (OSRAM)
ZA (1) ZA927429B (OSRAM)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
US5545660A (en) * 1992-04-07 1996-08-13 Merrell Pharmaceuticals Inc. Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans
CN1318434C (zh) * 1997-11-25 2007-05-30 安迪珀蒂恩生物工艺学有限公司 线粒体靶向的抗氧剂
AUPR549901A0 (en) 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
WO2003011303A1 (en) 2001-07-27 2003-02-13 Vital Health Sciences Pty Ltd Dermal therapy using phosphate derivatives of electron transfer agents
EP1374882B1 (de) * 2002-06-19 2008-10-01 Cognis IP Management GmbH Verwendung von Wirkstoffgemischen zur Herstellung eines Medikamentes gegen rheumatische Arthritis
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
CN1839142B (zh) 2003-08-22 2010-06-16 澳新制药公司 用作靶向线粒体的抗氧化剂的线粒体醌衍生物
US7888334B2 (en) 2003-08-22 2011-02-15 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants
CA2583087C (en) 2003-09-19 2012-07-10 Galileo Pharmaceuticals, Inc. Chroman derivatives
ATE495730T1 (de) 2004-03-03 2011-02-15 Vital Health Sciences Pty Ltd Alkaloid-formulierungen
EP1893159B1 (en) 2005-06-17 2015-09-30 Vital Health Sciences Pty Ltd. A carrier comprising one or more di- and/or monophosphate derivatives of electron transfer agents
US7813042B2 (en) 2005-09-12 2010-10-12 Sharp Kabushiki Kaisha Multiple-view directional display
US8687273B2 (en) 2006-09-07 2014-04-01 Sharp Kabushiki Kaisha Image display device, electronic device, and parallax barrier element
WO2011094814A1 (en) 2010-02-05 2011-08-11 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
WO2011120084A1 (en) 2010-03-30 2011-10-06 Phosphagenics Limited Transdermal delivery patch
US9561243B2 (en) 2011-03-15 2017-02-07 Phosphagenics Limited Composition comprising non-neutralised tocol phosphate and a vitamin A compound
ES2981002T3 (es) 2015-12-09 2024-10-04 Avecho Biotechnology Ltd Formulación farmacéutica
AU2017381395A1 (en) 2016-12-21 2019-06-20 Phosphagenics Limited Process

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62205091A (ja) * 1986-03-04 1987-09-09 Senjiyu Seiyaku Kk 新規なリン酸ジエステルならびにその塩、その製造法およびそれを含有する製剤
CA2002649C (en) * 1988-11-14 2000-06-06 Margaret Petty Cardioprotective tocopherol analogs
US5500444A (en) 1989-11-14 1996-03-19 Hoechst Marion Roussel, Inc. Cardioprotective tocopherol analogs
US5135945A (en) 1991-06-05 1992-08-04 Merrell Dow Pharmaceuticals Inc. Cholesterol-lowering tocopherol analogs

Also Published As

Publication number Publication date
TW224970B (OSRAM) 1994-06-11
FI924424A0 (fi) 1992-10-01
HU215123B (hu) 1998-09-28
HUT62592A (en) 1993-05-28
AU2538392A (en) 1993-04-08
KR100253108B1 (ko) 2000-05-01
HU9203134D0 (en) 1992-12-28
JP3230699B2 (ja) 2001-11-19
IL103305A0 (en) 1993-02-21
ZA927429B (en) 1993-04-07
DK0536036T3 (da) 1998-03-16
DE69224501D1 (de) 1998-04-02
DE69224501T2 (de) 1998-06-25
CA2079289C (en) 2003-02-18
ATE163421T1 (de) 1998-03-15
NO923840L (no) 1993-04-05
FI924424L (fi) 1993-04-03
FI105552B (fi) 2000-09-15
EP0536036A1 (en) 1993-04-07
AU652077B2 (en) 1994-08-11
EP0535283A1 (en) 1993-04-07
NZ244549A (en) 1994-07-26
NO923840D0 (no) 1992-10-01
JPH05310763A (ja) 1993-11-22
CA2079289A1 (en) 1993-04-03
GR3026242T3 (en) 1998-05-29
EP0536036B1 (en) 1998-02-25

Similar Documents

Publication Publication Date Title
ES2115656T3 (es) Analogos de tocoferol cardioprotectores.
ES2111092T3 (es) Derivados de acidos biliares, procedimiento para su preparacion y utilizacion de estos compuestos como medicamentos.
ES2116594T3 (es) Ansamicinas biciclicas y su uso como agentes antitumorales.
MX9301129A (es) Nuevas ciclosporinas y composiciones farmaceuticas que las contienen.
ES2176212T3 (es) Eteres de fosfonooximetilicos o metiltiometilicos de derivados de taxano como agentes antitumorales.
SV1995000042A (es) Heteroaril-oxazolidinonas de 5 eslabones ref. le a 30523-sv
ES542321A0 (es) Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina
ES2106965T3 (es) Nuevas 4-aza-5alfa-androstan-3-onas 7beta-sustituidas como inhibidores de 5alfa-reductasa.
ES2141559T3 (es) Derivados de 2-ciano-1-sulfonamidofenil-1,3-diona y su uso como herbicidas.
ES2119831T3 (es) 7-(sustituido)-9-((glicil sustituido)amido)-6-desmetil-6-desoxitetraciclinas.
ES2098140T3 (es) Liosferas que contienen gonadotropina.
ES2068179T3 (es) Benzo(5,6)-ciclohepta-piridinas, composiciones y metodo de uso.
ES2040727T3 (es) Un proceso para preparar una formulacion en aerosol en solucion de un analogo.
ES2136725T3 (es) Utilizacion de 2-amino-6-n-propil-amino-4,5,6,7-tetrahidrobenzotiazol (pramipexol) como medicamento con efecto antidepresivo.
IL64292A0 (en) D-homosteroids,their manufacture and pharmaceutical compositions containing them
ES2071674T3 (es) Analogos de tocoferol cardioprotectores.
ES2043665T3 (es) 6,11-dihidro-11-(4-piperidiliden)-5h-benzo-(5,6)-ciclohepta-(1,2-b)-piridinas y composiciones y metodos de uso.
ES2069921T3 (es) Antagonistas del nmda.
ES2054881T3 (es) Pantetina como agente inhibidor de la fibrosis hepatica.
ES2038163T3 (es) Procedimiento para preparar 1,3-dioxolanos trisustituidos en 2,4,4 y tetrasustituidos en 2,2,4,4.
AR059965A2 (es) Uso de 8,9-dehidroestrona para la preparacion de un medicamento antioxidante
UY24596A1 (es) Nuevos derivados sintéticos del catecol
MX9706744A (es) Proceso novedosos para preparar derivados de 2,3-dihidro-benzofuranol.
ES2059396T3 (es) Derivados de indeno y metodos.
ES2076141T3 (es) 5-aril-3h-1,2,4-triazol-3-onas y su uso como anticonvulsivos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 536036

Country of ref document: ES