ES2112310T3 - Caracterizacion de defectos de la agregacion de plaquetas. - Google Patents
Caracterizacion de defectos de la agregacion de plaquetas.Info
- Publication number
- ES2112310T3 ES2112310T3 ES92901259T ES92901259T ES2112310T3 ES 2112310 T3 ES2112310 T3 ES 2112310T3 ES 92901259 T ES92901259 T ES 92901259T ES 92901259 T ES92901259 T ES 92901259T ES 2112310 T3 ES2112310 T3 ES 2112310T3
- Authority
- ES
- Spain
- Prior art keywords
- defects
- characterization
- platelet aggregation
- union
- characterize
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000012512 characterization method Methods 0.000 title 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 title 1
- 230000004913 activation Effects 0.000 abstract 2
- 230000007547 defect Effects 0.000 abstract 2
- 238000004458 analytical method Methods 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 238000000684 flow cytometry Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Sampling And Sample Adjustment (AREA)
- Laminated Bodies (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
SE DESCRIBEN METODOS PARA CARACTERIZAR DEFECTOS EN LA CONGREGACION DE LAS PLAQUETAS. LOS DEFECTOS SE CARACTERIZAN COMO DEFECTOS DE ACTIVACION, DE UNION O DE POST-OCUPACION. EN UNA CONFORMACION DE LA INVENCION UNA VARIANTE DE CAM DE LA TROMBASTENIA DE GLANZMANN SE CARACTERIZA POR TENER UN DEFECTO DE UNION DE LOS LIGANTES. EN OTRA CONFORMACION, SE IDENTIFICA UN PACIENTE CON MIELOFIBROSIS POR TENER UN DEFECTO DE ACTIVACION. SE PRESENTAN ANALISIS RAPIDOS QUE UTILIZAN LA CITOMETRIA DE FLUJO ACTIVADA POR FLUORESCENCIA. TAMBIEN SE DESCRIBEN EQUIPOS DE DIAGNOSTICO QUE COMPRENDEN ANTICUERPOS ADECUADOS PARA CARACTERIZAR LOS DEFECTOS MENCIONADOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/614,723 US5196309A (en) | 1990-11-15 | 1990-11-15 | Characterization of platelet aggregation disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2112310T3 true ES2112310T3 (es) | 1998-04-01 |
Family
ID=24462455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92901259T Expired - Lifetime ES2112310T3 (es) | 1990-11-15 | 1991-11-15 | Caracterizacion de defectos de la agregacion de plaquetas. |
Country Status (13)
Country | Link |
---|---|
US (2) | US5196309A (es) |
EP (1) | EP0557451B1 (es) |
JP (1) | JP3186765B2 (es) |
AT (1) | ATE163481T1 (es) |
AU (1) | AU650312B2 (es) |
CA (1) | CA2096230C (es) |
DE (1) | DE69128966T2 (es) |
DK (1) | DK0557451T3 (es) |
ES (1) | ES2112310T3 (es) |
GR (1) | GR3026510T3 (es) |
IE (1) | IE62627B1 (es) |
PT (1) | PT99532B (es) |
WO (1) | WO1992008982A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5427913A (en) * | 1992-12-03 | 1995-06-27 | Alberta Cancer Board | Methods for determining platelet function |
US5763199A (en) * | 1994-09-29 | 1998-06-09 | Mount Sinai School Of Medicine Of The City University Of New York | Platelet blockade assay |
US5561047A (en) * | 1994-12-13 | 1996-10-01 | The Trustees Of The University Of Pennsylvania | Method of identifying effectors of integrin activation |
US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
GB9519667D0 (en) * | 1995-09-27 | 1995-11-29 | Univ Manchester | Pharmaceutical composition |
EP0983509B1 (en) * | 1997-05-14 | 2005-08-17 | Biosite Diagnostics Inc. | Rapid evaluation of the ratio of biological molecules |
AU7581798A (en) * | 1997-05-20 | 1998-12-11 | Johns Hopkins University, The | A novel thrombopoietin signaling defect in polycythemia vera platelets |
FR2764388B1 (fr) * | 1997-06-06 | 1999-08-27 | Biocytex | Nouvelle methode d'analyse des recepteurs plaquettaires gpiib/iiia |
US6210904B1 (en) | 1997-10-14 | 2001-04-03 | Merck & Co., Inc. | Anticoagulant test |
US6040182A (en) * | 1997-11-12 | 2000-03-21 | Becton Dickinson And Company | Method and materials for efficiency protein immobilization on tissue culture treated assay plates |
US6063584A (en) * | 1997-11-21 | 2000-05-16 | Merck & Co., Inc. | Anticoagulant test |
AU2002220255A1 (en) * | 2000-12-05 | 2002-06-18 | The Penn State Research Foundation | A monoclonal antibody-based diagnostic assay for gamma fibrinogen |
US20040131500A1 (en) * | 2002-01-18 | 2004-07-08 | Chow Herbert S. | Device and method for evaluating platelets |
US7790362B2 (en) | 2003-07-08 | 2010-09-07 | Accumetrics, Inc. | Controlled platelet activation to monitor therapy of ADP antagonists |
US20070243632A1 (en) | 2003-07-08 | 2007-10-18 | Coller Barry S | Methods for measuring platelet reactivity of patients that have received drug eluting stents |
JP2010261790A (ja) * | 2009-05-01 | 2010-11-18 | Takemichi Kanazawa | 血管障害の素因の検査方法、及び治療法の選択方法 |
WO2015138916A1 (en) * | 2014-03-14 | 2015-09-17 | Yves Claude Nicolau | Myo-inositol trispyrophoshate as an anti-diabetic agent |
BR112017015133B1 (pt) * | 2015-01-14 | 2022-09-27 | Sorin Dinu | Dispositivo resistente para o nivelamento da areia até a cota e para a montagem da tubulação no canal de esgoto |
CN111033256B (zh) | 2017-09-05 | 2022-07-12 | 深圳迈瑞生物医疗电子股份有限公司 | 血小板聚集样本的报警方法、血细胞分析仪及存储介质 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4783330A (en) * | 1984-11-15 | 1988-11-08 | New England Medical Center Hospitals, Inc. | Monoclonal antibodies to activated platelets |
US4820505A (en) * | 1985-04-04 | 1989-04-11 | Scripps Clinic And Research Foundation | Detection of activated platelets with antibodies to thrombospondin |
US5114842A (en) * | 1987-07-08 | 1992-05-19 | The Scripps Research Institute | Peptides and antibodies that inhibit platelet adhesion |
-
1990
- 1990-11-15 US US07/614,723 patent/US5196309A/en not_active Expired - Lifetime
-
1991
- 1991-11-14 IE IE397591A patent/IE62627B1/en not_active IP Right Cessation
- 1991-11-15 JP JP50230492A patent/JP3186765B2/ja not_active Expired - Fee Related
- 1991-11-15 WO PCT/US1991/008579 patent/WO1992008982A1/en active IP Right Grant
- 1991-11-15 PT PT99532A patent/PT99532B/pt not_active IP Right Cessation
- 1991-11-15 EP EP92901259A patent/EP0557451B1/en not_active Expired - Lifetime
- 1991-11-15 DK DK92901259T patent/DK0557451T3/da active
- 1991-11-15 CA CA002096230A patent/CA2096230C/en not_active Expired - Fee Related
- 1991-11-15 AT AT92901259T patent/ATE163481T1/de not_active IP Right Cessation
- 1991-11-15 AU AU90824/91A patent/AU650312B2/en not_active Ceased
- 1991-11-15 ES ES92901259T patent/ES2112310T3/es not_active Expired - Lifetime
- 1991-11-15 DE DE69128966T patent/DE69128966T2/de not_active Expired - Fee Related
-
1994
- 1994-06-23 US US08/264,759 patent/US5656442A/en not_active Expired - Lifetime
-
1998
- 1998-04-03 GR GR980400694T patent/GR3026510T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0557451A4 (en) | 1994-06-01 |
GR3026510T3 (en) | 1998-07-31 |
JP3186765B2 (ja) | 2001-07-11 |
DK0557451T3 (da) | 1998-09-23 |
AU650312B2 (en) | 1994-06-16 |
CA2096230A1 (en) | 1992-05-16 |
JPH06504842A (ja) | 1994-06-02 |
EP0557451B1 (en) | 1998-02-25 |
EP0557451A1 (en) | 1993-09-01 |
WO1992008982A1 (en) | 1992-05-29 |
PT99532B (pt) | 1999-04-30 |
DE69128966T2 (de) | 1998-06-18 |
US5196309A (en) | 1993-03-23 |
IE913975A1 (en) | 1992-05-20 |
AU9082491A (en) | 1992-06-11 |
CA2096230C (en) | 2003-05-27 |
IE62627B1 (en) | 1995-02-22 |
ATE163481T1 (de) | 1998-03-15 |
US5656442A (en) | 1997-08-12 |
DE69128966D1 (de) | 1998-04-02 |
PT99532A (pt) | 1992-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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