ES2111652T3 - Nuevo derivado de benzotiofeno. - Google Patents

Nuevo derivado de benzotiofeno.

Info

Publication number
ES2111652T3
ES2111652T3 ES92923415T ES92923415T ES2111652T3 ES 2111652 T3 ES2111652 T3 ES 2111652T3 ES 92923415 T ES92923415 T ES 92923415T ES 92923415 T ES92923415 T ES 92923415T ES 2111652 T3 ES2111652 T3 ES 2111652T3
Authority
ES
Spain
Prior art keywords
benzotiofeno
substituted
lower alkyl
new derivative
benzothiophene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92923415T
Other languages
English (en)
Inventor
Naoyuki Koizumi
Shigehiro Takegawa
Shigeki Iwashita
Tomoko Kawachi
Teruaki Matsui
Mamoru Mieda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Application granted granted Critical
Publication of ES2111652T3 publication Critical patent/ES2111652T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Abstract

UN DERIVADO DE BENZOTIOFENO REPRESENTADO POR LA FORMULA GENERAL (1) O UNA SAL CONSIGUIENTE, QUE TIENE UNA ACTIVIDAD ANTIESTROGENICA EXCELENTE Y ES UTIL PARA EL TRATAMIENTO DEL CANCER DE PECHO, CANCER ENDOMETRICO, ENDOMETROSIS, MASTOPATIA Y SIMILARES. ESTE COMPUESTO SE CARACTERIZA POR LA POSICION 2-, P.EJ., R2 SUSTITUYENTE, DEL ANILLO DE BENZOTIOFENO SE SUSTITUYE POR UN ATOMO DE HALOGENO, UN GRUPO ALQUILO INFERIOR O UN GRUPO CICLOALQUENILO O CICLOALQUILO QUE PUEDE ESTAR SUSTITUIDO POR UN ALQUILO INFERIOR, HIDROXIDO, ACICLOXIDO U OXO.
ES92923415T 1991-11-15 1992-11-11 Nuevo derivado de benzotiofeno. Expired - Lifetime ES2111652T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP32666691A JP3157882B2 (ja) 1991-11-15 1991-11-15 新規なベンゾチオフエン誘導体

Publications (1)

Publication Number Publication Date
ES2111652T3 true ES2111652T3 (es) 1998-03-16

Family

ID=18190312

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92923415T Expired - Lifetime ES2111652T3 (es) 1991-11-15 1992-11-11 Nuevo derivado de benzotiofeno.

Country Status (13)

Country Link
US (1) US5472962A (es)
EP (1) EP0641791B1 (es)
JP (1) JP3157882B2 (es)
KR (1) KR100220268B1 (es)
AT (1) ATE162788T1 (es)
AU (1) AU665588B2 (es)
CA (1) CA2123514C (es)
DE (1) DE69224308T2 (es)
DK (1) DK0641791T3 (es)
ES (1) ES2111652T3 (es)
GR (1) GR3026471T3 (es)
SG (1) SG47113A1 (es)
WO (1) WO1993010113A1 (es)

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US5472962A (en) 1995-12-05
DE69224308D1 (de) 1998-03-05
EP0641791A1 (en) 1995-03-08
CA2123514C (en) 2003-07-29
CA2123514A1 (en) 1993-05-27
SG47113A1 (en) 1998-03-20
GR3026471T3 (en) 1998-06-30
ATE162788T1 (de) 1998-02-15
AU2927692A (en) 1993-06-15
DE69224308T2 (de) 1998-05-20
EP0641791B1 (en) 1998-01-28
JPH05140148A (ja) 1993-06-08
WO1993010113A1 (en) 1993-05-27
KR100220268B1 (ko) 1999-09-15
JP3157882B2 (ja) 2001-04-16
DK0641791T3 (da) 1998-09-23
EP0641791A4 (en) 1994-11-22
AU665588B2 (en) 1996-01-11

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