ES2110404T3 - Inhibidores de proteasas retrovirales. - Google Patents

Inhibidores de proteasas retrovirales.

Info

Publication number
ES2110404T3
ES2110404T3 ES90123779T ES90123779T ES2110404T3 ES 2110404 T3 ES2110404 T3 ES 2110404T3 ES 90123779 T ES90123779 T ES 90123779T ES 90123779 T ES90123779 T ES 90123779T ES 2110404 T3 ES2110404 T3 ES 2110404T3
Authority
ES
Spain
Prior art keywords
glycosyl
acid
same
protease inhibitors
retroviral protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90123779T
Other languages
English (en)
Inventor
Karl-Heinz Dr Budt
Anuschirwan Dr Peyman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2110404T3 publication Critical patent/ES2110404T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA INVENCION SE REFIERE A UN COMPUESTO DE FORMULA (I), Y A UN PROCEDIMIENTO PARA OBTENERLO, SE DESCRIBE SU APLICACION COMO INHIBIDOR DE PROTEASAS RETROVIRALES TENIENDO A, Q, R (AL CUADRADO) , R ELEVADO A 3, R ELEVADO A 4, UN SIGNIFICADO DESCRITO EN LA PATENTE.
ES90123779T 1989-12-16 1990-12-11 Inhibidores de proteasas retrovirales. Expired - Lifetime ES2110404T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3941607 1989-12-16
DE4018942 1990-06-13

Publications (1)

Publication Number Publication Date
ES2110404T3 true ES2110404T3 (es) 1998-02-16

Family

ID=25888063

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90123779T Expired - Lifetime ES2110404T3 (es) 1989-12-16 1990-12-11 Inhibidores de proteasas retrovirales.

Country Status (19)

Country Link
US (1) US5629431A (es)
EP (1) EP0435059B1 (es)
JP (1) JP2816253B2 (es)
KR (1) KR100203231B1 (es)
AT (1) ATE159946T1 (es)
AU (1) AU641197B2 (es)
CA (1) CA2032303C (es)
DE (2) DE4039569A1 (es)
DK (1) DK0435059T3 (es)
ES (1) ES2110404T3 (es)
FI (1) FI906140A (es)
GR (1) GR3025765T3 (es)
HU (1) HUT59147A (es)
IE (1) IE904516A1 (es)
IL (1) IL96677A0 (es)
NO (1) NO306552B1 (es)
NZ (1) NZ236461A (es)
PL (1) PL288270A1 (es)
PT (1) PT96180B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0538374A4 (en) * 1990-07-06 1993-05-19 Smith-Kline Beecham Corporation Aspartic protease inhibitors
WO1993014114A1 (en) * 1992-01-09 1993-07-22 The Scripps Research Institute Peptide linkage unit comprising methylene phosphinic acid
DE4220566A1 (de) * 1992-06-24 1994-01-20 Hoechst Ag Inhibitoren retroviraler Proteasen
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
DE4310815A1 (de) * 1993-04-02 1994-10-06 Hoechst Ag Neue Bis(aminomethyl)phosphinsäure-Derviate und Verfahren zur Herstellung von Bis(aminomethyl)phosphinsäure-Derivaten
JP4482883B2 (ja) 2003-05-22 2010-06-16 リードケミカル株式会社 抗ウイルス作用を有する化合物およびその配合剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3359266A (en) * 1966-06-10 1967-12-19 Monsanto Co Process for preparing phosphorus-containing mannich bases
US4100275A (en) * 1975-01-27 1978-07-11 Hoffmann-La Roche Inc. Compositions having antibiotic properties
NZ218937A (en) * 1986-01-16 1990-03-27 Abbott Lab Functionalised peptidyl aminodiols and -triols as renin inhibitors and pharmaceutical compositions
DE3856166T2 (de) * 1987-09-29 1998-08-06 Banyu Pharma Co Ltd N-Acylaminosäurederivate und deren Verwendung
DE3824961A1 (de) * 1988-07-22 1990-01-25 Basf Ag Verfahren zur herstellung von bis(aminomethyl)-phosphinsaeure oder deren sauren oder basischen salzen
JPH04503214A (ja) * 1989-02-10 1992-06-11 シュラム，ヴォルフガング 対称性蛋白質、特に酵素を阻害する薬剤

Also Published As

Publication number Publication date
PL288270A1 (en) 1992-08-24
PT96180A (pt) 1991-09-30
IL96677A0 (en) 1991-09-16
US5629431A (en) 1997-05-13
NO905410D0 (no) 1990-12-14
FI906140A (fi) 1991-06-17
AU6802590A (en) 1991-06-20
ATE159946T1 (de) 1997-11-15
KR100203231B1 (ko) 1999-06-15
HUT59147A (en) 1992-04-28
CA2032303A1 (en) 1991-06-17
DK0435059T3 (da) 1998-07-27
NO905410L (no) 1991-06-17
GR3025765T3 (en) 1998-03-31
FI906140A0 (fi) 1990-12-13
JP2816253B2 (ja) 1998-10-27
AU641197B2 (en) 1993-09-16
EP0435059B1 (de) 1997-11-05
NZ236461A (en) 1993-08-26
KR910011889A (ko) 1991-08-07
JPH05331067A (ja) 1993-12-14
HU908276D0 (en) 1991-06-28
IE904516A1 (en) 1991-06-19
DE59010771D1 (de) 1997-12-11
DE4039569A1 (de) 1991-06-20
NO306552B1 (no) 1999-11-22
CA2032303C (en) 2002-03-19
EP0435059A1 (de) 1991-07-03
PT96180B (pt) 1998-05-29

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