ES2109131A1 - Composicion farmaceutica que tiene actividad analgesica. - Google Patents

Composicion farmaceutica que tiene actividad analgesica.

Info

Publication number
ES2109131A1
ES2109131A1 ES09400644A ES9400644A ES2109131A1 ES 2109131 A1 ES2109131 A1 ES 2109131A1 ES 09400644 A ES09400644 A ES 09400644A ES 9400644 A ES9400644 A ES 9400644A ES 2109131 A1 ES2109131 A1 ES 2109131A1
Authority
ES
Spain
Prior art keywords
analgesic activity
pharmaceutical composition
arginine
naphthyl
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09400644A
Other languages
English (en)
Other versions
ES2109131B1 (es
Inventor
Federico Stroppolo
Daniele Bonadeo
Luigi Vigano
Annibale Gazzaniga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon Group SpA
Zambon SpA
Original Assignee
Zambon Group SpA
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Group SpA, Zambon SpA filed Critical Zambon Group SpA
Publication of ES2109131A1 publication Critical patent/ES2109131A1/es
Application granted granted Critical
Publication of ES2109131B1 publication Critical patent/ES2109131B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COMPOSICION FARMACEUTICA QUE TIENE ACTIVIDAD ANALGESICA, Y QUE CONTIENE ACIDO (S)-2-(6-METOXI-2-NAFTIL) - PROPIONICO (NAPROXEN), JUNTO CON ARGININA Y UNA SUBSTANCIA BASICA AUXILIAR FARMACEUTICAMENTE COMPATIBLE. LA RELACION MOLAR ENTRE EL NAPROXEN Y LA ARGININA ESTA ENTRE 1:0,8 A 1:1,5. LA SUBSTANCIA BASICA AUXILIAR ESTA CON RESPECTO AL NAPROXEN EN UNA RELACION MOLAR DE HASTA 0,7. LA SOLUCION ACUOSA RESULTANTE AL DISOLVER EN AGUA TIENE UN PH DE 7,5-9,0. ESTA COMPOSICION FARMACEUTICA SE UTILIZA PARA LA PREPARACION DE FORMULACIONES FARMACEUTICAS PARA USO ORAL QUE PERMITEN OBTENER UNA ANTICIPACION SIGNIFICATIVA DEL INICIO DEL EFECTO ANALGESICO.
ES09400644A 1993-03-26 1994-03-25 Composicion farmaceutica que tiene actividad analgesica. Expired - Fee Related ES2109131B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI930582A IT1272149B (it) 1993-03-26 1993-03-26 Composizione farmeceutiche ad attivita' analgesica

Publications (2)

Publication Number Publication Date
ES2109131A1 true ES2109131A1 (es) 1998-01-01
ES2109131B1 ES2109131B1 (es) 1998-08-16

Family

ID=11365508

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09400644A Expired - Fee Related ES2109131B1 (es) 1993-03-26 1994-03-25 Composicion farmaceutica que tiene actividad analgesica.

Country Status (12)

Country Link
US (1) US5693312A (es)
JP (1) JP3784843B2 (es)
BE (1) BE1006718A3 (es)
CA (1) CA2120048C (es)
CH (1) CH686403A5 (es)
DE (1) DE4410470A1 (es)
ES (1) ES2109131B1 (es)
FR (1) FR2703249B1 (es)
GB (1) GB2276545B (es)
IT (1) IT1272149B (es)
NL (1) NL194390C (es)
SE (1) SE517006C2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1301966B1 (it) 1998-07-30 2000-07-20 Zambon Spa Composizioni farmaceutiche ad attivita' analgesica
GB9924636D0 (en) * 1999-10-18 1999-12-22 Norgine Bv Laxative preparation
US20030235629A1 (en) * 1999-11-06 2003-12-25 Janmarie Hornack Dietary supplement containing alkaline electrolyte buffers
US6727286B2 (en) 2001-11-02 2004-04-27 Cumberland Pharmaceuticals Inc. Pharmaceutical composition of 2-(4-isobutylphenyl) propionic acid
ES2253326T3 (es) * 2001-11-02 2006-06-01 Cumberland Pharmaceuticals Inc. Composicion farmaceutica de acido 2-(4-isobutilfenilo)propionico.
BRPI0409127A (pt) * 2003-04-11 2006-03-28 Pfizer combinação farmacêutica compreendendo eletriptano e bicarbonato de sódio
US20050008699A1 (en) * 2003-07-11 2005-01-13 Fred Wehling Effervescent glucosamine composition
UY28583A1 (es) * 2003-10-30 2005-05-31 Roche Consumer Health Ag Forma de presentación del naproxeno sodico
US20050137262A1 (en) * 2003-12-22 2005-06-23 Hu Patrick C. Highly concentrated pourable aqueous solutions of potassium ibuprofen, their preparation and their uses
EP1905427B1 (en) 2006-09-28 2010-11-24 Losan Pharma GmbH Rapidly solubilising formulation of non-steroidal anti-inflammatory drugs
US8828452B2 (en) * 2007-05-22 2014-09-09 Glenn Abrahmsohn Method for pain control
JP2010528040A (ja) * 2007-05-22 2010-08-19 グレン エイブラムソーン， 疼痛管理のための方法
BRPI0800951A2 (pt) * 2008-04-09 2012-02-22 Ems Sa novos compostos derivados de taurina e seus usos, processo de sua preparação e composições farmacêuticas contendo os mesmos
JP7163014B2 (ja) * 2016-10-31 2022-10-31 エスエス製薬株式会社 感冒薬
JP7163015B2 (ja) * 2016-10-31 2022-10-31 エスエス製薬株式会社 経口固形組成物
US11779541B2 (en) * 2019-03-26 2023-10-10 Johnson & Johnson Consumer Inc. Immediate release dosage form

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904682A (en) * 1967-01-13 1975-09-09 Syntex Corp 2-(6{40 -Methoxy-2{40 -naphthyl)acetic acid
FR2262975A1 (es) * 1974-03-07 1975-10-03 Prodotti Antibiotici Spa
US4748174A (en) * 1986-01-03 1988-05-31 Therapicon S.R.L. Water soluble salts of an NSAID with meglumine/glucamine
US4834966A (en) * 1986-08-01 1989-05-30 Zambon S.P.A. Pharmaceutical composition with analgesic activity
EP0486046A2 (de) * 1990-11-15 1992-05-20 MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG Komplexe, enthaltend S(+)-Phenyl-alkansäuren und Aminozucker
EP0486045A2 (de) * 1990-11-15 1992-05-20 MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG Komplexe, enthaltend S-(+)-Phenyl-alkansäuren und alpha-Aminosäuren

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4344929A (en) * 1980-04-25 1982-08-17 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US4587249A (en) * 1982-07-22 1986-05-06 Analgesic Associates Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
US5053396A (en) * 1985-08-27 1991-10-01 Blass David H Therapeutic composition
IT1209667B (it) * 1985-11-12 1989-08-30 Zambon Spa Composizione effeverscente adattivita' analgesica.
SE463541B (sv) * 1987-08-31 1990-12-10 Lejus Medical Ab Granulaer produkt oeverdragen av en smaelta av sig sjaelv samt foerfarande foer dess framstaellning
GB8724763D0 (en) * 1987-10-22 1987-11-25 Aps Research Ltd Sustained-release formulations
GB8813682D0 (en) * 1988-06-09 1988-07-13 Reckitt & Colmann Prod Ltd Pharmaceutical compositions
KR920700613A (ko) * 1989-05-16 1992-08-10 지구르트 퓌터 약제제
US5262179A (en) * 1989-09-13 1993-11-16 Nicholas Kiwi Pty Ltd. Non-effervescent ibuprofen compositions

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904682A (en) * 1967-01-13 1975-09-09 Syntex Corp 2-(6{40 -Methoxy-2{40 -naphthyl)acetic acid
FR2262975A1 (es) * 1974-03-07 1975-10-03 Prodotti Antibiotici Spa
US4748174A (en) * 1986-01-03 1988-05-31 Therapicon S.R.L. Water soluble salts of an NSAID with meglumine/glucamine
US4834966A (en) * 1986-08-01 1989-05-30 Zambon S.P.A. Pharmaceutical composition with analgesic activity
EP0486046A2 (de) * 1990-11-15 1992-05-20 MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG Komplexe, enthaltend S(+)-Phenyl-alkansäuren und Aminozucker
EP0486045A2 (de) * 1990-11-15 1992-05-20 MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG Komplexe, enthaltend S-(+)-Phenyl-alkansäuren und alpha-Aminosäuren

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEM. ABS. Vol. 102, 1985 (Columbus, Ohio, U.S.A.) pßgina 336, columna 1, resumen n‘ 225919f *

Also Published As

Publication number Publication date
BE1006718A3 (fr) 1994-11-22
US5693312A (en) 1997-12-02
SE9401005D0 (sv) 1994-03-25
NL9400481A (nl) 1994-10-17
GB2276545B (en) 1996-08-14
FR2703249A1 (fr) 1994-10-07
DE4410470A1 (de) 1994-09-29
ITMI930582A0 (it) 1993-03-26
FR2703249B1 (fr) 1995-07-13
JPH06321777A (ja) 1994-11-22
GB9405420D0 (en) 1994-05-04
NL194390C (nl) 2002-03-04
JP3784843B2 (ja) 2006-06-14
CA2120048C (en) 2004-01-27
GB2276545A (en) 1994-10-05
CA2120048A1 (en) 1994-09-27
SE517006C2 (sv) 2002-04-02
IT1272149B (it) 1997-06-11
ES2109131B1 (es) 1998-08-16
ITMI930582A1 (it) 1994-09-26
SE9401005L (sv) 1994-09-27
NL194390B (nl) 2001-11-01
CH686403A5 (it) 1996-03-29

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