ES2108129T3 - Nuevos derivados de pirazina, su preparacion y empleo. - Google Patents
Nuevos derivados de pirazina, su preparacion y empleo.Info
- Publication number
- ES2108129T3 ES2108129T3 ES92916697T ES92916697T ES2108129T3 ES 2108129 T3 ES2108129 T3 ES 2108129T3 ES 92916697 T ES92916697 T ES 92916697T ES 92916697 T ES92916697 T ES 92916697T ES 2108129 T3 ES2108129 T3 ES 2108129T3
- Authority
- ES
- Spain
- Prior art keywords
- pirazine
- preparation
- new derivatives
- compounds
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Liquid Crystal Substances (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4127026A DE4127026A1 (de) | 1991-08-16 | 1991-08-16 | Neue pyrazinderivate, ihre herstellung und verwendung |
| DE19914130461 DE4130461A1 (de) | 1991-09-13 | 1991-09-13 | Neue pyrazinderivate, ihre herstellung und verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2108129T3 true ES2108129T3 (es) | 1997-12-16 |
Family
ID=25906394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92916697T Expired - Lifetime ES2108129T3 (es) | 1991-08-16 | 1992-07-31 | Nuevos derivados de pirazina, su preparacion y empleo. |
Country Status (22)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6645969B1 (en) | 1991-05-10 | 2003-11-11 | Aventis Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase |
| IL109570A0 (en) * | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
| DE4325822A1 (de) * | 1993-07-31 | 1995-02-02 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| US5852046A (en) * | 1993-08-03 | 1998-12-22 | Hoechst Aktiengesellschaft | Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them |
| DE4337609A1 (de) * | 1993-11-04 | 1995-05-11 | Boehringer Ingelheim Kg | Neue Pyrazincarboxamidderivate, ihre Herstellung und ihre Verwendung in Arzneimitteln |
| DE4412334A1 (de) * | 1994-04-11 | 1995-10-19 | Hoechst Ag | Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| US5760230A (en) * | 1996-10-11 | 1998-06-02 | Bayer Aktiengesellschaft | 4, 4'-bridged bis-2, 4-diaminoquinazolines |
| US6420354B1 (en) * | 1998-06-08 | 2002-07-16 | Advanced Medicine, Inc. | Sodium channel drugs and uses |
| IT1312310B1 (it) * | 1999-05-07 | 2002-04-15 | Recordati Ind Chimica E Farma | Uso di antagonisti selettivi del recettore adrenergico a 1b per ilmiglioramento della disfunzione sessuale |
| EP1182194A4 (en) | 1999-06-03 | 2004-02-11 | Takeda Chemical Industries Ltd | PERNASAL COMPOSITIONS |
| US6479498B1 (en) | 1999-06-04 | 2002-11-12 | Theravance, Inc. | Sodium channel drugs and uses |
| US6156758A (en) * | 1999-09-08 | 2000-12-05 | Isis Pharmaceuticals, Inc. | Antibacterial quinazoline compounds |
| AU2003218736B2 (en) * | 2002-03-13 | 2009-01-08 | Janssen Pharmaceutica N.V. | New inhibitors of histone deacetylase |
| CN1984660B (zh) | 2003-07-03 | 2010-12-15 | 美瑞德生物工程公司 | 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉 |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| AU2004270162B2 (en) | 2003-08-28 | 2010-05-13 | Nicox S.A. | Nitrosated ad nitrosylated diuretic compouds, compositions and methods of use |
| CA2592900A1 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| US7396829B2 (en) | 2005-02-24 | 2008-07-08 | Nitromed, Inc. | Nitric oxide enhancing diuretic compounds, compositions and methods of use |
| DE102008061247A1 (de) * | 2008-12-10 | 2010-06-24 | Christian-Albrechts-Universität Zu Kiel | Inhibitoren der Dimethylarginin Dimethylaminohydrolase |
| US8987288B2 (en) * | 2010-09-10 | 2015-03-24 | Hangzhou Bensheng Pharmaceutical Co., Ltd. | Heterocyclic aminoberbamine derivatives, the preparation process and use thereof |
| CN110041291B (zh) * | 2018-01-15 | 2021-02-26 | 北京采瑞医药科技研究院有限公司 | 一种玛咖酰胺衍生物及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE639386A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1962-10-30 | |||
| US3527758A (en) * | 1967-04-13 | 1970-09-08 | Merck & Co Inc | Process for the preparation of pyrazinoylguanidines from a pyrazinoic azide and a guanidine |
| US3539569A (en) * | 1968-08-21 | 1970-11-10 | Merck & Co Inc | Preparation of pyrazinoylguanidines from pyrazinoylureas |
| NL7803906A (nl) * | 1978-04-12 | 1979-10-16 | Noordvos Schroeven Bv | Werkwijze, inrichting en propeller voor het verdelen van een gasvormig, poedervormig of vloeibaar materiaal in een vloeistof. |
| GB8712365D0 (en) * | 1987-05-26 | 1987-07-01 | Ici America Inc | Aminomethylphenolic pyrazines |
-
1992
- 1992-07-28 TW TW081105973A patent/TW213903B/zh active
- 1992-07-31 FI FI940696A patent/FI940696A0/fi unknown
- 1992-07-31 DE DE59208974T patent/DE59208974D1/de not_active Expired - Fee Related
- 1992-07-31 DK DK92916697.3T patent/DK0598770T3/da active
- 1992-07-31 CA CA002115755A patent/CA2115755A1/en not_active Abandoned
- 1992-07-31 EP EP92916697A patent/EP0598770B1/de not_active Expired - Lifetime
- 1992-07-31 AT AT92916697T patent/ATE159250T1/de not_active IP Right Cessation
- 1992-07-31 CZ CZ94337A patent/CZ280760B6/cs unknown
- 1992-07-31 JP JP5504057A patent/JPH06509798A/ja active Pending
- 1992-07-31 SG SG1996002613A patent/SG46307A1/en unknown
- 1992-07-31 RU RU94015265A patent/RU2124008C1/ru active
- 1992-07-31 WO PCT/EP1992/001738 patent/WO1993004048A1/de active IP Right Grant
- 1992-07-31 SK SK175-94A patent/SK17594A3/sk unknown
- 1992-07-31 ES ES92916697T patent/ES2108129T3/es not_active Expired - Lifetime
- 1992-07-31 AU AU23870/92A patent/AU669122B2/en not_active Ceased
- 1992-07-31 HU HU9400430A patent/HUT67661A/hu unknown
- 1992-08-11 MX MX9204637A patent/MX9204637A/es not_active IP Right Cessation
- 1992-08-14 NZ NZ243959A patent/NZ243959A/en unknown
- 1992-08-14 IL IL102814A patent/IL102814A0/xx unknown
- 1992-08-17 IE IE259292A patent/IE922592A1/en not_active IP Right Cessation
-
1994
- 1994-02-15 NO NO940523A patent/NO301542B1/no unknown
-
1997
- 1997-12-23 GR GR970403392T patent/GR3025742T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX9204637A (es) | 1993-02-01 |
| IE922592A1 (en) | 1993-02-24 |
| FI940696L (fi) | 1994-02-15 |
| JPH06509798A (ja) | 1994-11-02 |
| CA2115755A1 (en) | 1993-03-04 |
| RU94015265A (ru) | 1997-02-20 |
| EP0598770A1 (de) | 1994-06-01 |
| AU2387092A (en) | 1993-03-16 |
| AU669122B2 (en) | 1996-05-30 |
| SK17594A3 (en) | 1994-12-07 |
| NO301542B1 (no) | 1997-11-10 |
| IL102814A0 (en) | 1993-01-31 |
| FI940696A7 (fi) | 1994-02-15 |
| CZ280760B6 (cs) | 1996-04-17 |
| HU9400430D0 (en) | 1994-05-30 |
| DE59208974D1 (de) | 1997-11-20 |
| FI940696A0 (fi) | 1994-02-15 |
| NO940523D0 (no) | 1994-02-15 |
| TW213903B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-10-01 |
| NO940523L (no) | 1994-02-15 |
| HK1003137A1 (en) | 1998-10-09 |
| DK0598770T3 (da) | 1997-12-15 |
| GR3025742T3 (en) | 1998-03-31 |
| RU2124008C1 (ru) | 1998-12-27 |
| HUT67661A (en) | 1995-04-28 |
| SG46307A1 (en) | 1998-02-20 |
| ATE159250T1 (de) | 1997-11-15 |
| NZ243959A (en) | 1995-07-26 |
| CZ33794A3 (en) | 1994-07-13 |
| EP0598770B1 (de) | 1997-10-15 |
| WO1993004048A1 (de) | 1993-03-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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