ES2107682T3 - Analogos noveles de la vitamina d. - Google Patents

Analogos noveles de la vitamina d.

Info

Publication number
ES2107682T3
ES2107682T3 ES93921832T ES93921832T ES2107682T3 ES 2107682 T3 ES2107682 T3 ES 2107682T3 ES 93921832 T ES93921832 T ES 93921832T ES 93921832 T ES93921832 T ES 93921832T ES 2107682 T3 ES2107682 T3 ES 2107682T3
Authority
ES
Spain
Prior art keywords
pct
alkyl
hydrogen
stands
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93921832T
Other languages
English (en)
Inventor
Kai Hansen
Claus Aage Svensgaard Bretting
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Application granted granted Critical
Publication of ES2107682T3 publication Critical patent/ES2107682T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)

Abstract

LA INVENCION DESCRIBE UNOS COMPONENTES DE FORMULA (I) EN LOS QUE LA FORMULA Q ES -CH2-, -CH=CH- O -C=C-; U ES UN ALQUILENO C1-C6; R1 ES HIDROGENO, ALQUILO C1-C4 O YR'' EN EL QUE Y SOPORTA LOS RADICALES SO- O -SO2- Y R'' SOPORTA UN ALQUILO C1-C4; R2 Y R3 SON INDEPENDIENTEMENTE HIDROGENO O UN ALQUILO C1-C4, Y ADICIONALMENTE CUANDO SE TOMAN JUNTO AL ATOMO DE CARBONO ESTRELLADO, PUEDEN FORMAR UN ANILLO CARBOCICLICO C3-C6; Z ES HIDROGENO O HIDROXI; Y SUS DERIVADOS. LOS COMPONENTES MUESTRAN EFECTOS ANTIINFLAMATORIOS Y DE INMUNOMODULACION ASI COMO UNA FUERTE ACTIVIDAD EN INDUCIR A LA DIFERENCIACION E INHIBICION DE LA PROLIFERACION NO DESEADA DE CIERTAS CELULAS.
ES93921832T 1992-09-28 1993-09-27 Analogos noveles de la vitamina d. Expired - Lifetime ES2107682T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929220439A GB9220439D0 (en) 1992-09-28 1992-09-28 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2107682T3 true ES2107682T3 (es) 1997-12-01

Family

ID=10722627

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93921832T Expired - Lifetime ES2107682T3 (es) 1992-09-28 1993-09-27 Analogos noveles de la vitamina d.

Country Status (16)

Country Link
US (1) US5589471A (es)
EP (1) EP0662954B1 (es)
JP (1) JPH08501572A (es)
KR (1) KR100295976B1 (es)
AT (1) ATE157085T1 (es)
AU (1) AU668774B2 (es)
CA (1) CA2140247C (es)
DE (1) DE69313295T2 (es)
DK (1) DK0662954T3 (es)
ES (1) ES2107682T3 (es)
FI (1) FI109686B (es)
GB (1) GB9220439D0 (es)
GR (1) GR3025280T3 (es)
NZ (1) NZ256390A (es)
RU (1) RU2165923C2 (es)
WO (1) WO1994007852A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242434B1 (en) 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
GB9526208D0 (en) 1995-12-21 1996-02-21 Res Inst Medicine Chem Chemical compounds
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
EP1091936B1 (en) 1998-05-29 2003-07-30 Bone Care International, Inc. Method for making hydroxy-25-ene-vitamin d compounds
US5972917A (en) * 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
US6359012B1 (en) 1999-12-22 2002-03-19 Bone Care International, Inc. Method for making 24(S)-hydroxyvitamin D2
KR100982466B1 (ko) 2001-10-19 2010-09-16 이소테크니카 인코포레이티드 시클로스포린 유사체의 합성
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
EP1812011A1 (en) 2004-11-12 2007-08-01 Bioxell S.p.a. Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
US20110166631A1 (en) 2008-07-10 2011-07-07 Breining Peter M Luminescent cycle regulator and fertility indicator
EP2393494A1 (en) 2009-01-27 2011-12-14 Berg Biosystems, LLC Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
CA2770683C (en) 2009-08-14 2018-09-04 Berg Biosystems, Llc Vitamin d3 and analogs thereof for treating alopecia
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904154D0 (en) * 1989-02-23 1989-04-05 Leo Pharm Prod Ltd Chemical compounds
ATE143007T1 (de) * 1991-07-05 1996-10-15 Duphar Int Res Vitamin-d derivat, verfahren zu dessen herstellung sowie zwischenprodukte dafür

Also Published As

Publication number Publication date
FI951447A (fi) 1995-03-27
JPH08501572A (ja) 1996-02-20
NZ256390A (en) 1997-06-24
DK0662954T3 (da) 1997-12-08
AU668774B2 (en) 1996-05-16
CA2140247C (en) 2003-12-09
AU5108093A (en) 1994-04-26
DE69313295T2 (de) 1998-03-19
GB9220439D0 (en) 1992-11-11
EP0662954A1 (en) 1995-07-19
DE69313295D1 (de) 1997-09-25
FI109686B (fi) 2002-09-30
KR950702529A (ko) 1995-07-29
RU2165923C2 (ru) 2001-04-27
CA2140247A1 (en) 1994-04-14
US5589471A (en) 1996-12-31
WO1994007852A1 (en) 1994-04-14
GR3025280T3 (en) 1998-02-27
FI951447A0 (fi) 1995-03-27
EP0662954B1 (en) 1997-08-20
RU94046458A (ru) 1997-01-10
ATE157085T1 (de) 1997-09-15
KR100295976B1 (ko) 2001-11-14

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