ES2107473T3 - Procedimiento para la funcionalizacion directa y regioselectiva en posicion 2 de fenotiazina. - Google Patents

Procedimiento para la funcionalizacion directa y regioselectiva en posicion 2 de fenotiazina.

Info

Publication number
ES2107473T3
ES2107473T3 ES92101872T ES92101872T ES2107473T3 ES 2107473 T3 ES2107473 T3 ES 2107473T3 ES 92101872 T ES92101872 T ES 92101872T ES 92101872 T ES92101872 T ES 92101872T ES 2107473 T3 ES2107473 T3 ES 2107473T3
Authority
ES
Spain
Prior art keywords
phenotiazine
procedure
direct
regioselective functionalization
regioselective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92101872T
Other languages
English (en)
Inventor
Claudio Giordano
Maurizio Paiocchi
Paolo Cavalleri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon Group SpA
Zambon SpA
Original Assignee
Zambon Group SpA
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Group SpA, Zambon SpA filed Critical Zambon Group SpA
Application granted granted Critical
Publication of ES2107473T3 publication Critical patent/ES2107473T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C07D279/30—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with acyl radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA FUNCIONALIZACION DIRECTA Y REGIOSELECTIVA EN LA POSICION 2 DE LA FENOTIAZINA QUE PERMITE LA INTRODUCCION DE UN GRUPO SH EN LA POSICION 2. LA 2-MERCAPTO-FENOTIAZINA ASI OBTENIDA ES UN INTERMEDIARIO IMPORTANTE PARA LA PREPARACION DE COMPUESTOS FARMACOLOGICAMENTE ACTIVOS.
ES92101872T 1991-02-14 1992-02-05 Procedimiento para la funcionalizacion directa y regioselectiva en posicion 2 de fenotiazina. Expired - Lifetime ES2107473T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI910379A IT1244742B (it) 1991-02-14 1991-02-14 Processo per la funzionalizzazione diretta e regioselettiva in posizione 2 della fenotiazina

Publications (1)

Publication Number Publication Date
ES2107473T3 true ES2107473T3 (es) 1997-12-01

Family

ID=11358569

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92101872T Expired - Lifetime ES2107473T3 (es) 1991-02-14 1992-02-05 Procedimiento para la funcionalizacion directa y regioselectiva en posicion 2 de fenotiazina.

Country Status (7)

Country Link
US (1) US5362871A (es)
EP (1) EP0499126B1 (es)
JP (1) JP3089373B2 (es)
AT (1) ATE157091T1 (es)
DE (1) DE69221648T2 (es)
ES (1) ES2107473T3 (es)
IT (1) IT1244742B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284279B1 (en) * 1999-12-03 2001-09-04 Avecia, Inc. Phenothiazine in prill form and method for making the same
DE10032137B4 (de) 2000-07-01 2009-04-02 Allessachemie Gmbh Verfahren zur Herstellung von Phenothiazin-Granulat mit verbesserten Eigenschaften
KR20140048891A (ko) * 2011-05-27 2014-04-24 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 치환된 2-벤질리덴-2H-벤조[b][1,4]티아진-3(4H)-온, 이의 유도체, 및 이의 치료적 용도

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207789A1 (es) * 1974-01-22 1976-10-29 Rhone Poulenc Ind Procedimiento para preparar nuevos esteres derivados de 2-hidroxi-2-dimetilsulfamoil-6-(((hidroxi-2-etil)-4-pipedidino)-3-propil)-10-fenotiazina
US4578379A (en) * 1980-05-30 1986-03-25 University Of Georgia Research Foundation, Inc. Use of phenothiazine 5-oxide drugs as vaginal contraceptives
IT1237209B (it) * 1989-12-21 1993-05-27 Zambon Spa Processo per la funzionalizzazione diretta e regioselettiva in posizione 2 della fenotiazina
ES2079504T3 (es) * 1990-04-09 1996-01-16 Zambon Spa Procedimiento para la funcionalizacion directa y regioselectiva en posicion 2 de fenotiacina.

Also Published As

Publication number Publication date
EP0499126A3 (en) 1992-10-21
JP3089373B2 (ja) 2000-09-18
JPH0586042A (ja) 1993-04-06
IT1244742B (it) 1994-08-08
EP0499126A2 (en) 1992-08-19
US5362871A (en) 1994-11-08
DE69221648D1 (de) 1997-09-25
DE69221648T2 (de) 1998-03-26
ITMI910379A1 (it) 1992-08-14
ITMI910379A0 (it) 1991-02-14
ATE157091T1 (de) 1997-09-15
EP0499126B1 (en) 1997-08-20

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