ES2107473T3 - Procedimiento para la funcionalizacion directa y regioselectiva en posicion 2 de fenotiazina. - Google Patents
Procedimiento para la funcionalizacion directa y regioselectiva en posicion 2 de fenotiazina.Info
- Publication number
- ES2107473T3 ES2107473T3 ES92101872T ES92101872T ES2107473T3 ES 2107473 T3 ES2107473 T3 ES 2107473T3 ES 92101872 T ES92101872 T ES 92101872T ES 92101872 T ES92101872 T ES 92101872T ES 2107473 T3 ES2107473 T3 ES 2107473T3
- Authority
- ES
- Spain
- Prior art keywords
- phenotiazine
- procedure
- direct
- regioselective functionalization
- regioselective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000007306 functionalization reaction Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/30—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with acyl radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE DESCRIBE UN PROCEDIMIENTO PARA LA FUNCIONALIZACION DIRECTA Y REGIOSELECTIVA EN LA POSICION 2 DE LA FENOTIAZINA QUE PERMITE LA INTRODUCCION DE UN GRUPO SH EN LA POSICION 2. LA 2-MERCAPTO-FENOTIAZINA ASI OBTENIDA ES UN INTERMEDIARIO IMPORTANTE PARA LA PREPARACION DE COMPUESTOS FARMACOLOGICAMENTE ACTIVOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI910379A IT1244742B (it) | 1991-02-14 | 1991-02-14 | Processo per la funzionalizzazione diretta e regioselettiva in posizione 2 della fenotiazina |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2107473T3 true ES2107473T3 (es) | 1997-12-01 |
Family
ID=11358569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92101872T Expired - Lifetime ES2107473T3 (es) | 1991-02-14 | 1992-02-05 | Procedimiento para la funcionalizacion directa y regioselectiva en posicion 2 de fenotiazina. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5362871A (es) |
EP (1) | EP0499126B1 (es) |
JP (1) | JP3089373B2 (es) |
AT (1) | ATE157091T1 (es) |
DE (1) | DE69221648T2 (es) |
ES (1) | ES2107473T3 (es) |
IT (1) | IT1244742B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6284279B1 (en) * | 1999-12-03 | 2001-09-04 | Avecia, Inc. | Phenothiazine in prill form and method for making the same |
DE10032137B4 (de) | 2000-07-01 | 2009-04-02 | Allessachemie Gmbh | Verfahren zur Herstellung von Phenothiazin-Granulat mit verbesserten Eigenschaften |
JP2014522396A (ja) * | 2011-05-27 | 2014-09-04 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 置換2−ベンジリデン−2H−ベンゾ[b][1,4]チアジン−3(4H)−オン、その誘導体及びその治療上の使用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR205635A1 (es) * | 1974-01-22 | 1976-05-21 | Rhone Poulenc Ind | Procedimiento para preparar nuevos derivados de la (((hidroxi-2 etil)-4-piperidino) -3 propil) -10 fenotiazina |
US4578379A (en) * | 1980-05-30 | 1986-03-25 | University Of Georgia Research Foundation, Inc. | Use of phenothiazine 5-oxide drugs as vaginal contraceptives |
IT1237209B (it) * | 1989-12-21 | 1993-05-27 | Zambon Spa | Processo per la funzionalizzazione diretta e regioselettiva in posizione 2 della fenotiazina |
EP0451675B1 (en) * | 1990-04-09 | 1995-11-02 | ZAMBON GROUP S.p.A. | Process for the direct and regioselective functionalization in position 2 of phenothiazine |
-
1991
- 1991-02-14 IT ITMI910379A patent/IT1244742B/it active IP Right Grant
-
1992
- 1992-02-05 AT AT92101872T patent/ATE157091T1/de not_active IP Right Cessation
- 1992-02-05 DE DE69221648T patent/DE69221648T2/de not_active Expired - Fee Related
- 1992-02-05 ES ES92101872T patent/ES2107473T3/es not_active Expired - Lifetime
- 1992-02-05 EP EP92101872A patent/EP0499126B1/en not_active Expired - Lifetime
- 1992-02-12 US US07/833,800 patent/US5362871A/en not_active Expired - Fee Related
- 1992-02-14 JP JP04079403A patent/JP3089373B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE157091T1 (de) | 1997-09-15 |
IT1244742B (it) | 1994-08-08 |
ITMI910379A0 (it) | 1991-02-14 |
DE69221648D1 (de) | 1997-09-25 |
EP0499126A2 (en) | 1992-08-19 |
US5362871A (en) | 1994-11-08 |
DE69221648T2 (de) | 1998-03-26 |
JPH0586042A (ja) | 1993-04-06 |
JP3089373B2 (ja) | 2000-09-18 |
EP0499126B1 (en) | 1997-08-20 |
ITMI910379A1 (it) | 1992-08-14 |
EP0499126A3 (en) | 1992-10-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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