DE3262037D1 - 17-cyclopropylmethyl-3-hydroxy-14-methoxy 7 alpha-methylmorphinan-6-one - Google Patents

17-cyclopropylmethyl-3-hydroxy-14-methoxy 7 alpha-methylmorphinan-6-one

Info

Publication number
DE3262037D1
DE3262037D1 DE8282105424T DE3262037T DE3262037D1 DE 3262037 D1 DE3262037 D1 DE 3262037D1 DE 8282105424 T DE8282105424 T DE 8282105424T DE 3262037 T DE3262037 T DE 3262037T DE 3262037 D1 DE3262037 D1 DE 3262037D1
Authority
DE
Germany
Prior art keywords
cyclopropylmethyl
methoxy
alpha
hydroxy
methylmorphinan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282105424T
Other languages
English (en)
Inventor
Anil Chandra Ghosh
Raj Kumar Razdan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Application granted granted Critical
Publication of DE3262037D1 publication Critical patent/DE3262037D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE8282105424T 1981-06-29 1982-06-21 17-cyclopropylmethyl-3-hydroxy-14-methoxy 7 alpha-methylmorphinan-6-one Expired DE3262037D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/278,760 US4370333A (en) 1981-06-29 1981-06-29 17-Cyclopropylmethyl-3-hydroxy-14-methoxy 7α-methyl-morphinan-6-one and therapeutic method of treating pain with it

Publications (1)

Publication Number Publication Date
DE3262037D1 true DE3262037D1 (de) 1985-03-07

Family

ID=23066241

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282105424T Expired DE3262037D1 (de) 1981-06-29 1982-06-21 17-cyclopropylmethyl-3-hydroxy-14-methoxy 7 alpha-methylmorphinan-6-one

Country Status (6)

Country Link
US (1) US4370333A (de)
EP (1) EP0068384B1 (de)
JP (1) JPS588067A (de)
AT (1) ATE11410T1 (de)
CA (1) CA1172251A (de)
DE (1) DE3262037D1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4715703A (en) * 1982-10-12 1987-12-29 Rodenstock Instrument Corporation Ocular-fundus analyzer
TWI365880B (en) * 2004-03-30 2012-06-11 Euro Celtique Sa Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
WO2006126529A1 (ja) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
TW201441199A (zh) 2012-12-28 2014-11-01 Purdue Pharma Lp 經取代之嗎啡喃類及其用途
WO2014102587A1 (en) * 2012-12-28 2014-07-03 Purdue Pharma L.P. 7,8-cyclicmorphinan analogs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3654280A (en) * 1968-03-21 1972-04-04 Shionogi & Co L-n allylic-3-hydroxy-6-oxomorphinans
CA1093070A (en) * 1978-02-10 1981-01-06 Michael P. Kotick 8.beta.-ALKYL-SUBSTITUTED MORPHINAN-6-ONE COMPOUNDS
US4272540A (en) * 1979-04-24 1981-06-09 Sisa, Incorporated 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
CA1135692A (en) * 1979-05-21 1982-11-16 Michael P. Kotick 7-methyl and 7-methyl-8-lower alkyl b/c cis or trans morphinan-6-one compounds

Also Published As

Publication number Publication date
ATE11410T1 (de) 1985-02-15
EP0068384B1 (de) 1985-01-23
US4370333A (en) 1983-01-25
JPS588067A (ja) 1983-01-18
CA1172251A (en) 1984-08-07
EP0068384A1 (de) 1983-01-05

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee