ES2107464T3 - Compuestos agonistas del receptor h3 de la histamina para utilizacion terapeutica, composiciones farmaceuticas que actuan como agonistas de dicho receptor y procedimiento de preparacion. - Google Patents
Compuestos agonistas del receptor h3 de la histamina para utilizacion terapeutica, composiciones farmaceuticas que actuan como agonistas de dicho receptor y procedimiento de preparacion.Info
- Publication number
- ES2107464T3 ES2107464T3 ES91910312T ES91910312T ES2107464T3 ES 2107464 T3 ES2107464 T3 ES 2107464T3 ES 91910312 T ES91910312 T ES 91910312T ES 91910312 T ES91910312 T ES 91910312T ES 2107464 T3 ES2107464 T3 ES 2107464T3
- Authority
- ES
- Spain
- Prior art keywords
- receptor
- pharmaceutical compositions
- compounds
- pct
- therapeutic use
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LOS COMPUESTOS PROCEDEN DE UNA AMINA R-NH SUB 2 QUE TIENE UNA FUERTE AFINIDAD PARA EL RECEPTOR H SUB 3 DE LA HISTAMINA Y CON FUNCION AMINA PRIMARIA CON LA QUE ESTA UNIDO UN GRUPO QUE DETERMINA UN ENLACE LENTAMENTE HIDROLIZABLE EN MEDIO NEUTRO. LAS COMPOSICIONES FARMACEUTICAS COMPRENDEN ESTOS COMPUESTOS Y UN VEHICULO O EXIPIENTE FARMACEUTICAMENTE ACEPTABLE. ESTOS COMPUESTOS SE UTILIZAN PARA LA REALIZACION DE UN MEDICAMENTO INHIBIDOR DE LA SINTESIS Y DE LA LIBERACION DE HISTAMINA, EN PARTICULAR CON EFECTOS SEDANTES, REGULADOR DEL SUEÑO, ANTICONVULSIVO, ANTIDEPRESIVO, ANTIALERGICO, ANTIINFLAMATORIO, ANTISECRETORIO O ANTIULCEROSO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9005776A FR2661909B1 (fr) | 1990-05-09 | 1990-05-09 | Nouveaux composes agonistes du recepteur h3 de l'histamine a usage therapeutique, compositions pharmaceutiques agissant comme agonistes dudit recepteur et procede de preparation. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2107464T3 true ES2107464T3 (es) | 1997-12-01 |
Family
ID=9396429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91910312T Expired - Lifetime ES2107464T3 (es) | 1990-05-09 | 1991-05-10 | Compuestos agonistas del receptor h3 de la histamina para utilizacion terapeutica, composiciones farmaceuticas que actuan como agonistas de dicho receptor y procedimiento de preparacion. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5342960A (es) |
EP (1) | EP0482183B1 (es) |
JP (1) | JP3094384B2 (es) |
AT (1) | ATE156121T1 (es) |
CA (1) | CA2063550C (es) |
DE (1) | DE69127045T2 (es) |
DK (1) | DK0482183T3 (es) |
ES (1) | ES2107464T3 (es) |
FR (1) | FR2661909B1 (es) |
GR (1) | GR3024991T3 (es) |
WO (1) | WO1991017146A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU662588B2 (en) * | 1991-12-18 | 1995-09-07 | Schering Corporation | Imidazolyl-alkyl-piperazine and -diazepine derivatives as histamine H3 agonists/antagonists |
US5633250A (en) * | 1991-12-18 | 1997-05-27 | Schering Corporation | Imidazoylalkyl substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms |
EP0633882A1 (en) * | 1992-04-01 | 1995-01-18 | The University Of Toledo | 4- 4'-piperidinyl or 3'-pirrolidinyl] substituted imidazoles as h3-receptor antagonists and therapeutic uses thereof |
US5639775A (en) * | 1992-04-01 | 1997-06-17 | The University Of Toledo | 4-[4'-piperodinyl or 3'-pirrolidinyl] substituted imidazoles as H3 -receptor antagonists and therapeutic uses thereof |
US5486526A (en) * | 1992-04-01 | 1996-01-23 | The University Of Toledo | Histamine H3 -receptor antagonists and therapeutic uses thereof |
US6407132B1 (en) | 1997-07-25 | 2002-06-18 | James Black Foundation Limited | Substituted imidazole derivatives and their use as histamine H3 receptor ligands |
JP2000189171A (ja) | 1998-12-25 | 2000-07-11 | Banyu Pharmaceut Co Ltd | 新規なグアノシン三リン酸(gtp)結合タンパク質共役型のレセプタ―タンパク質 |
AU3033100A (en) | 1999-01-18 | 2000-08-01 | Boehringer Ingelheim International Gmbh | Substituted imidazoles, their preparation and use |
US6908926B1 (en) | 1999-04-16 | 2005-06-21 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
US6610721B2 (en) | 2000-03-17 | 2003-08-26 | Novo Nordisk A/S | Imidazo heterocyclic compounds |
US6437147B1 (en) | 2000-03-17 | 2002-08-20 | Novo Nordisk | Imidazole compounds |
CA2483701A1 (en) | 2002-04-24 | 2003-11-06 | Banyu Pharmaceutical Co., Ltd. | Constitutively active histamine h3 receptor mutants and uses thereof |
EP1879567A1 (en) | 2005-04-28 | 2008-01-23 | Pfizer Limited | Amino acid derivatives |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT71651B (en) * | 1979-08-15 | 1982-01-21 | Merck & Co Inc | Process for preparing allysulfoxide enzyme inhibitors |
FR2548183B1 (fr) * | 1983-07-01 | 1985-10-31 | Synthelabo | Diphenylazomethines portant un radical imidazolyle, leur preparation et leur application en therapeutique |
NL8501093A (nl) * | 1985-04-12 | 1986-11-03 | Stamicarbon | Werkwijze voor het racemiseren van een optisch aktief n- benzylideenaminozuuramide. |
FR2586562B1 (fr) * | 1985-09-02 | 1989-03-10 | Inst Nat Sante Rech Med | Composition pharmaceutique contenant de l'a-methylhistamine |
FR2630328B1 (fr) * | 1988-04-22 | 1990-08-24 | Inst Nat Sante Rech Med | Derive de l'histamine, sa preparation et son application en therapeutique |
-
1990
- 1990-05-09 FR FR9005776A patent/FR2661909B1/fr not_active Expired - Fee Related
-
1991
- 1991-05-10 US US07/828,936 patent/US5342960A/en not_active Expired - Lifetime
- 1991-05-10 AT AT91910312T patent/ATE156121T1/de not_active IP Right Cessation
- 1991-05-10 EP EP91910312A patent/EP0482183B1/fr not_active Expired - Lifetime
- 1991-05-10 DE DE69127045T patent/DE69127045T2/de not_active Expired - Lifetime
- 1991-05-10 WO PCT/FR1991/000384 patent/WO1991017146A1/fr active IP Right Grant
- 1991-05-10 ES ES91910312T patent/ES2107464T3/es not_active Expired - Lifetime
- 1991-05-10 DK DK91910312.7T patent/DK0482183T3/da active
- 1991-05-10 CA CA002063550A patent/CA2063550C/en not_active Expired - Lifetime
- 1991-05-10 JP JP03509563A patent/JP3094384B2/ja not_active Expired - Lifetime
-
1997
- 1997-10-09 GR GR970402634T patent/GR3024991T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FR2661909B1 (fr) | 1997-08-14 |
US5342960A (en) | 1994-08-30 |
ATE156121T1 (de) | 1997-08-15 |
JPH06501241A (ja) | 1994-02-10 |
EP0482183A1 (fr) | 1992-04-29 |
GR3024991T3 (en) | 1998-01-30 |
WO1991017146A1 (fr) | 1991-11-14 |
DE69127045T2 (de) | 1998-03-05 |
DK0482183T3 (da) | 1998-03-09 |
DE69127045D1 (de) | 1997-09-04 |
FR2661909A1 (fr) | 1991-11-15 |
CA2063550A1 (en) | 1991-11-10 |
JP3094384B2 (ja) | 2000-10-03 |
EP0482183B1 (fr) | 1997-07-30 |
CA2063550C (en) | 2002-02-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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