ES2100558T3 - Antiepilepticos analogos del vpa. - Google Patents
Antiepilepticos analogos del vpa.Info
- Publication number
- ES2100558T3 ES2100558T3 ES93918997T ES93918997T ES2100558T3 ES 2100558 T3 ES2100558 T3 ES 2100558T3 ES 93918997 T ES93918997 T ES 93918997T ES 93918997 T ES93918997 T ES 93918997T ES 2100558 T3 ES2100558 T3 ES 2100558T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- image
- formulae
- hydrogen
- antiepilepticos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/18—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon triple bonds as unsaturation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/126—Acids containing more than four carbon atoms
- C07C53/128—Acids containing more than four carbon atoms the carboxylic group being bound to a carbon atom bound to at least two other carbon atoms, e.g. neo-acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
- C07C53/134—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings monocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/03—Monocarboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Socks And Pantyhose (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Electrotherapy Devices (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Abstract
LA INVENCION SE REFIERE A COMPUESTOS, QUE SON ANTIEPILEPTICOS ACTIVOS DISPONIENDO SOLAMENTE DE ACCION SEDANTE BAJA O TERATOGENICA Y DISPONIENDO DE FORMULAS (I), (II), (III) O (IV) PUDIENDO TENER LOS COMPUESTOS DE LAS FORMULAS (I) Y (II) MULTIPLES ENLACES NO SATURADOS, DONDE R1, R2, R3 Y R4, INDEPENDIENTE UNO DE OTRO, PUEDEN SER UN GRUPO C1 - C6 - ALQUIL, R5 ES HIDROGENO O UN GRUPO C1 - C2 - ALQUIL Y DONDE EN LOS COMPUESTOS DE LAS FORMULAS (I) Y (II) AL MENOS UNO DE LOS RESTOS R1 HASTA R4 ES DIFERENTE DE HIDROGENO. EN LOS COMPUESTOS DE LA FORMULA (I) PARA EL CASO DE QUE UN ATOMO DE CARBONO ESTE PRESENTE EN LA POSICION 2 SE FORMA UN CENTRO DE ASIMETRIA, Y LOS COMPUESTOS DE LAS FORMULAS (II), (III) Y (IV) SE ENCUENTRAN PRESENTES EN FORMA DE SUS RACEMATOS, SUS ENANTIOMEROS PUROS O UNA DE LAS MEZCLAS DIFERENTES DE RACEMATO DE SUS ENANTIOMEROS, Y SUS SALES TOLERABLES FARMACEUTICAMENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4231085A DE4231085A1 (de) | 1992-09-12 | 1992-09-12 | VPA-analoge Antiepileptika |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2100558T3 true ES2100558T3 (es) | 1997-06-16 |
Family
ID=6468160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93918997T Expired - Lifetime ES2100558T3 (es) | 1992-09-12 | 1993-09-10 | Antiepilepticos analogos del vpa. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5786380A (es) |
EP (1) | EP0659172B1 (es) |
JP (1) | JP2887419B2 (es) |
KR (1) | KR100244883B1 (es) |
AT (1) | ATE151067T1 (es) |
AU (1) | AU683425B2 (es) |
CA (1) | CA2144419A1 (es) |
DE (2) | DE4231085A1 (es) |
DK (1) | DK0659172T3 (es) |
ES (1) | ES2100558T3 (es) |
GR (1) | GR3023558T3 (es) |
HK (1) | HK1008016A1 (es) |
NZ (2) | NZ299727A (es) |
WO (1) | WO1994006743A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE163006T1 (de) * | 1993-06-01 | 1998-02-15 | Ono Pharmaceutical Co | Pentansäurederivate |
US6300373B1 (en) * | 1993-09-10 | 2001-10-09 | American Biogenetic Sciences, Inc. | Antiproliferative and neurotrophic molecules |
US5672746A (en) * | 1994-08-30 | 1997-09-30 | American Biogenetic Sciences, Inc. | Antiproliferative and neurotrophic molecules |
US5717109A (en) * | 1994-09-08 | 1998-02-10 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
IL124118A (en) * | 1998-04-16 | 2007-09-20 | Yissum Res Dev Co | Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, method for their synthesis and pharmaceutical compositions containing them |
CA2335603A1 (en) * | 1998-06-22 | 1999-12-29 | Heinz Nau | Alpha-fluoro alkynoic acids with anticonvulsant activity |
CZ20004833A3 (cs) | 1998-06-22 | 2002-01-16 | American Biogenetic Sciences, Inc. | Léčivo pro léčení a/nebo prevenci migrény a afektivní choroby |
US6969732B2 (en) * | 1999-04-12 | 2005-11-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, a method for their synthesis and pharmaceutical compositions containing them |
DE10002945A1 (de) * | 2000-01-13 | 2001-07-26 | Heinz Nau | Verfahren zur Herstellung von enantiomerenreinen Analoga der Valproinsäure |
US6521790B2 (en) | 2000-11-01 | 2003-02-18 | Abbott Laboratories | Alkynyl amides and their therapeutic applications |
CA2501861C (en) * | 2002-10-09 | 2012-03-20 | Waters Investments Limited | Methods and apparatus for identifying compounds in a sample |
US20060223888A1 (en) * | 2002-12-16 | 2006-10-05 | Abbott Frank S | Valproic acid analogues and pharmaceutical composition thereof |
AU2009327316B2 (en) * | 2008-12-20 | 2015-06-04 | Ase Pharmaceuticals, Llc | [2.2.2] bicyclic derivatives and methods of use |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2442M (fr) * | 1962-10-17 | 1964-04-06 | Henry Eugene | L'acide dipropylacétique et ses dérivés en tant que nouveuax médicaments dépresseurs du systeme nerveux central. |
DE2854195A1 (de) * | 1978-12-15 | 1980-06-26 | Technochemie Gmbh | Verfahren zur herstellung von dipropylessigsaeure |
DE3718803A1 (de) * | 1987-06-02 | 1988-12-15 | Desitin Arzneimittel Gmbh | Verfahren zur herstellung von e-2-propyl-2-pentensaeure und physiologisch vertraeglichen salzen derselben |
-
1992
- 1992-09-12 DE DE4231085A patent/DE4231085A1/de not_active Withdrawn
-
1993
- 1993-09-10 DK DK93918997.3T patent/DK0659172T3/da active
- 1993-09-10 WO PCT/DE1993/000861 patent/WO1994006743A1/de active IP Right Grant
- 1993-09-10 JP JP6507680A patent/JP2887419B2/ja not_active Expired - Fee Related
- 1993-09-10 KR KR1019950700951A patent/KR100244883B1/ko not_active IP Right Cessation
- 1993-09-10 AU AU49442/93A patent/AU683425B2/en not_active Ceased
- 1993-09-10 AT AT93918997T patent/ATE151067T1/de not_active IP Right Cessation
- 1993-09-10 ES ES93918997T patent/ES2100558T3/es not_active Expired - Lifetime
- 1993-09-10 EP EP93918997A patent/EP0659172B1/de not_active Expired - Lifetime
- 1993-09-10 DE DE59306054T patent/DE59306054D1/de not_active Expired - Fee Related
- 1993-09-10 NZ NZ299727A patent/NZ299727A/xx unknown
- 1993-09-10 CA CA002144419A patent/CA2144419A1/en not_active Abandoned
- 1993-09-10 NZ NZ255317A patent/NZ255317A/en unknown
-
1994
- 1994-11-23 US US08/344,810 patent/US5786380A/en not_active Expired - Fee Related
-
1997
- 1997-05-26 GR GR970401209T patent/GR3023558T3/el unknown
-
1998
- 1998-06-26 HK HK98107077A patent/HK1008016A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0659172B1 (de) | 1997-04-02 |
DK0659172T3 (da) | 1997-05-05 |
NZ255317A (en) | 1996-12-20 |
NZ299727A (en) | 2000-11-24 |
CA2144419A1 (en) | 1994-03-31 |
AU683425B2 (en) | 1997-11-13 |
JPH08502045A (ja) | 1996-03-05 |
US5786380A (en) | 1998-07-28 |
DE4231085A1 (de) | 1994-03-17 |
WO1994006743A1 (de) | 1994-03-31 |
ATE151067T1 (de) | 1997-04-15 |
AU4944293A (en) | 1994-04-12 |
GR3023558T3 (en) | 1997-08-29 |
HK1008016A1 (en) | 1999-04-30 |
JP2887419B2 (ja) | 1999-04-26 |
EP0659172A1 (de) | 1995-06-28 |
DE59306054D1 (de) | 1997-05-07 |
KR100244883B1 (ko) | 2000-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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