DK0659172T3 - VPA-analogt antiepileptikum - Google Patents

VPA-analogt antiepileptikum

Info

Publication number
DK0659172T3
DK0659172T3 DK93918997.3T DK93918997T DK0659172T3 DK 0659172 T3 DK0659172 T3 DK 0659172T3 DK 93918997 T DK93918997 T DK 93918997T DK 0659172 T3 DK0659172 T3 DK 0659172T3
Authority
DK
Denmark
Prior art keywords
compounds
image
formulae
hydrogen
antiepileptic
Prior art date
Application number
DK93918997.3T
Other languages
English (en)
Inventor
Heinz Nau
Ursula Bojic
Ralf-Siegbert Hauck
Mohamed Mohey Eldin Elmazar
Original Assignee
Heinz Nau
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heinz Nau filed Critical Heinz Nau
Application granted granted Critical
Publication of DK0659172T3 publication Critical patent/DK0659172T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/18—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon triple bonds as unsaturation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/126—Acids containing more than four carbon atoms
    • C07C53/128—Acids containing more than four carbon atoms the carboxylic group being bound to a carbon atom bound to at least two other carbon atoms, e.g. neo-acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • C07C53/134—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Socks And Pantyhose (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Electrotherapy Devices (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
DK93918997.3T 1992-09-12 1993-09-10 VPA-analogt antiepileptikum DK0659172T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4231085A DE4231085A1 (de) 1992-09-12 1992-09-12 VPA-analoge Antiepileptika

Publications (1)

Publication Number Publication Date
DK0659172T3 true DK0659172T3 (da) 1997-05-05

Family

ID=6468160

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93918997.3T DK0659172T3 (da) 1992-09-12 1993-09-10 VPA-analogt antiepileptikum

Country Status (14)

Country Link
US (1) US5786380A (da)
EP (1) EP0659172B1 (da)
JP (1) JP2887419B2 (da)
KR (1) KR100244883B1 (da)
AT (1) ATE151067T1 (da)
AU (1) AU683425B2 (da)
CA (1) CA2144419A1 (da)
DE (2) DE4231085A1 (da)
DK (1) DK0659172T3 (da)
ES (1) ES2100558T3 (da)
GR (1) GR3023558T3 (da)
HK (1) HK1008016A1 (da)
NZ (2) NZ255317A (da)
WO (1) WO1994006743A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE163006T1 (de) 1993-06-01 1998-02-15 Ono Pharmaceutical Co Pentansäurederivate
US6300373B1 (en) * 1993-09-10 2001-10-09 American Biogenetic Sciences, Inc. Antiproliferative and neurotrophic molecules
US5672746A (en) 1994-08-30 1997-09-30 American Biogenetic Sciences, Inc. Antiproliferative and neurotrophic molecules
US5717109A (en) * 1994-09-08 1998-02-10 Eli Lilly And Company Excitatory amino acid receptor antagonists
IL124118A (en) * 1998-04-16 2007-09-20 Yissum Res Dev Co Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, method for their synthesis and pharmaceutical compositions containing them
EP1089960A1 (en) * 1998-06-22 2001-04-11 American Biogenetic Sciences, Inc. Alpha-fluoro alkynoic acids with anticonvulsant activity
BR9911421A (pt) 1998-06-22 2001-03-27 American Biogenetic Sciences Uso de análogo do ácido valpróico para o tratamento e prevenção da enxaqueca e doenças emocionais
US6969732B2 (en) * 1999-04-12 2005-11-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, a method for their synthesis and pharmaceutical compositions containing them
DE10002945A1 (de) * 2000-01-13 2001-07-26 Heinz Nau Verfahren zur Herstellung von enantiomerenreinen Analoga der Valproinsäure
US6521790B2 (en) 2000-11-01 2003-02-18 Abbott Laboratories Alkynyl amides and their therapeutic applications
JP4795688B2 (ja) * 2002-10-09 2011-10-19 ウオーターズ・テクノロジーズ・コーポレイシヨン サンプル中の化合物を同定する方法および装置
AU2003289782A1 (en) * 2002-12-16 2004-07-09 The University Of British Columbia Valproic acid analogues and pharmaceutical compositions thereof
CA3075760C (en) * 2008-12-20 2021-09-07 Ase Pharmaceuticals, Llc [2.2.2] bicyclic derivatives and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2442M (fr) * 1962-10-17 1964-04-06 Henry Eugene L'acide dipropylacétique et ses dérivés en tant que nouveuax médicaments dépresseurs du systeme nerveux central.
DE2854195A1 (de) * 1978-12-15 1980-06-26 Technochemie Gmbh Verfahren zur herstellung von dipropylessigsaeure
DE3718803A1 (de) * 1987-06-02 1988-12-15 Desitin Arzneimittel Gmbh Verfahren zur herstellung von e-2-propyl-2-pentensaeure und physiologisch vertraeglichen salzen derselben

Also Published As

Publication number Publication date
EP0659172A1 (de) 1995-06-28
JPH08502045A (ja) 1996-03-05
AU683425B2 (en) 1997-11-13
DE4231085A1 (de) 1994-03-17
KR100244883B1 (ko) 2000-02-15
HK1008016A1 (en) 1999-04-30
GR3023558T3 (en) 1997-08-29
JP2887419B2 (ja) 1999-04-26
DE59306054D1 (de) 1997-05-07
US5786380A (en) 1998-07-28
AU4944293A (en) 1994-04-12
ES2100558T3 (es) 1997-06-16
ATE151067T1 (de) 1997-04-15
EP0659172B1 (de) 1997-04-02
NZ255317A (en) 1996-12-20
CA2144419A1 (en) 1994-03-31
NZ299727A (en) 2000-11-24
WO1994006743A1 (de) 1994-03-31

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