DE69521615D1 - Streptogramine in gereinigter form, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen - Google Patents

Streptogramine in gereinigter form, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen

Info

Publication number
DE69521615D1
DE69521615D1 DE69521615T DE69521615T DE69521615D1 DE 69521615 D1 DE69521615 D1 DE 69521615D1 DE 69521615 T DE69521615 T DE 69521615T DE 69521615 T DE69521615 T DE 69521615T DE 69521615 D1 DE69521615 D1 DE 69521615D1
Authority
DE
Germany
Prior art keywords
alkyl
dialkylamino
alkylamino
halogen
ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69521615T
Other languages
English (en)
Other versions
DE69521615T2 (de
Inventor
Pascal Anger
Jean-Claude Barriere
Bertrand Bonnavaud
Patrick Lefevre
Jean-Marc Paris
Denis Thibaut
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9465984&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69521615(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of DE69521615D1 publication Critical patent/DE69521615D1/de
Application granted granted Critical
Publication of DE69521615T2 publication Critical patent/DE69521615T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06182—Dipeptides with the first amino acid being heterocyclic and Pristinamycin II; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69521615T 1994-08-02 1995-07-31 Streptogramine in gereinigter form, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen Expired - Fee Related DE69521615T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9409564A FR2723373B1 (fr) 1994-08-02 1994-08-02 Forme purifiee de streptogramines, sa preparation et les compositions pharmaceutiques qui la contiennent
PCT/FR1995/001026 WO1996004298A1 (fr) 1994-08-02 1995-07-31 Forme purifiee de streptogramines, sa preparation et les compositions pharmaceutiques qui la contiennent

Publications (2)

Publication Number Publication Date
DE69521615D1 true DE69521615D1 (de) 2001-08-09
DE69521615T2 DE69521615T2 (de) 2002-05-08

Family

ID=9465984

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69521615T Expired - Fee Related DE69521615T2 (de) 1994-08-02 1995-07-31 Streptogramine in gereinigter form, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen

Country Status (13)

Country Link
US (1) US6384014B1 (de)
EP (1) EP0773956B1 (de)
JP (1) JPH10503511A (de)
AT (1) ATE202784T1 (de)
AU (1) AU3117495A (de)
CA (1) CA2196450A1 (de)
DE (1) DE69521615T2 (de)
DK (1) DK0773956T3 (de)
ES (1) ES2160171T3 (de)
FR (1) FR2723373B1 (de)
GR (1) GR3036173T3 (de)
PT (1) PT773956E (de)
WO (1) WO1996004298A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2354409A1 (en) * 1997-12-24 1999-07-08 Teresa J. Ingram Compositions comprising equisetum and symphytum and methods for the treatment of symptoms associated with mycoplasma infection
FR2775288B1 (fr) * 1998-02-26 2000-03-31 Rhone Poulenc Rorer Sa Derives de streptogramines, leur preparation et les compositons qui les contiennent
DK1204676T3 (da) * 1999-07-27 2003-12-01 Aventis Pharma Sa Streptograminderivater, deres fremstilling samt præparater indeholdende disse derivater
FR2796950B1 (fr) * 1999-07-27 2001-09-21 Aventis Pharma Sa Derives de streptogramines, leur preparation et les compositions qui les contiennent
US6919340B2 (en) 2002-04-19 2005-07-19 Cellular Genomics, Inc. Imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof
WO2004022562A1 (en) 2002-09-09 2004-03-18 Cellular Genomics, Inc. 6-ARYL-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF
WO2004072081A1 (en) 2003-02-10 2004-08-26 Cellular Genomics, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
US7393848B2 (en) 2003-06-30 2008-07-01 Cgi Pharmaceuticals, Inc. Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
US7259164B2 (en) 2003-08-11 2007-08-21 Cgi Pharmaceuticals, Inc. Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity
WO2007024294A2 (en) 2005-05-03 2007-03-01 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
US7776535B2 (en) 2006-02-06 2010-08-17 Franklin And Marshall College Site-specific incorporation of fluorinated amino acids into proteins
EP2252617A1 (de) 2008-02-13 2010-11-24 CGI Pharmaceuticals, Inc. 6-arylimidazo[1,2-a]pyrazinderivate, herstellungsverfahren und verfahren zu deren anwendung
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
JP5696052B2 (ja) 2008-12-08 2015-04-08 ギリアード コネチカット， インコーポレイテッド イミダゾピラジンｓｙｋ阻害剤
KR20170013414A (ko) 2008-12-08 2017-02-06 질레드 코네티컷 인코포레이티드 이미다조피라진 ｓｙｋ 억제제
US9562056B2 (en) 2010-03-11 2017-02-07 Gilead Connecticut, Inc. Imidazopyridines Syk inhibitors
NZ715776A (en) 2013-07-30 2017-04-28 Gilead Connecticut Inc Polymorph of syk inhibitors
PE20160605A1 (es) 2013-07-30 2016-07-20 Gilead Connecticut Inc Formulaciones de inhibidores de la syk
PT3076976T (pt) 2013-12-04 2020-12-07 Kronos Bio Inc Métodos para tratar cancros
TWI735853B (zh) 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 脾酪胺酸激酶抑制劑
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
AU2015290000B2 (en) 2014-07-14 2018-05-17 Gilead Sciences, Inc. Combinations for treating cancers
WO2019040298A1 (en) 2017-08-25 2019-02-28 Gilead Sciences, Inc. SYK INHIBITORY POLYMORPHS
MX2021010131A (es) 2019-02-22 2021-11-18 Kronos Bio Inc Formas sólidas de pirazinas condensadas a manera de inhibidores de syk.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2549063B1 (fr) 1983-07-13 1985-10-25 Rhone Poulenc Sante Nouveaux derives de synergistines, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2549062B1 (fr) 1983-07-13 1985-10-25 Rhone Poulenc Sante Nouveaux derives de synergistines, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2576022B1 (fr) 1985-01-11 1987-09-11 Rhone Poulenc Sante Nouveaux derives de la pristinamycine ii b, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2599036B1 (fr) 1986-05-22 1988-09-09 Rhone Poulenc Sante Nouveaux derives de synergistines, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2619008B1 (fr) 1987-08-03 1990-06-29 Cird Utilisation de synergistines dans des compositions pharmaceutiques ou cosmetiques anti-acneiques
FR2674539B1 (fr) * 1991-03-28 1993-05-21 Rhone Poulenc Rorer Sa Procede de preparation enzymatique de macrolactone.
FR2696189B1 (fr) 1992-09-25 1994-11-10 Rhone Poulenc Rorer Sa Polypeptides impliqués dans la biosynthèse des streptogramines, séquences nucléotidiques codant pour ces polypeptides et leur utilisation.
IL121821A (en) 1993-02-17 2000-02-17 Rhone Poulenc Rorer Sa Process for purifying a group A minority component of streptogramin some such purified components and their uses
FR2701709B1 (fr) 1993-02-17 1995-04-07 Rhone Poulenc Rorer Sa Forme purifiée de streptograminés, sa préparation et les compositions pharmaceutiques qui la contiennent.

Also Published As

Publication number Publication date
DK0773956T3 (da) 2001-09-24
FR2723373A1 (fr) 1996-02-09
EP0773956B1 (de) 2001-07-04
DE69521615T2 (de) 2002-05-08
WO1996004298A1 (fr) 1996-02-15
PT773956E (pt) 2001-11-30
CA2196450A1 (fr) 1996-02-15
ATE202784T1 (de) 2001-07-15
AU3117495A (en) 1996-03-04
FR2723373B1 (fr) 1996-09-13
GR3036173T3 (en) 2001-10-31
EP0773956A1 (de) 1997-05-21
JPH10503511A (ja) 1998-03-31
US6384014B1 (en) 2002-05-07
ES2160171T3 (es) 2001-11-01

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee