ES2100274T3 - Nuevos 2-sacarinilmetil y 4,5,6,7-tetrahidro-2-sacarinilmetil fosfatos, fosfonatos y fosfinatos utiles como inhibidores de enzimas proteoliticos y composiciones y metodos de empleo de los mismos. - Google Patents
Nuevos 2-sacarinilmetil y 4,5,6,7-tetrahidro-2-sacarinilmetil fosfatos, fosfonatos y fosfinatos utiles como inhibidores de enzimas proteoliticos y composiciones y metodos de empleo de los mismos.Info
- Publication number
- ES2100274T3 ES2100274T3 ES92204032T ES92204032T ES2100274T3 ES 2100274 T3 ES2100274 T3 ES 2100274T3 ES 92204032 T ES92204032 T ES 92204032T ES 92204032 T ES92204032 T ES 92204032T ES 2100274 T3 ES2100274 T3 ES 2100274T3
- Authority
- ES
- Spain
- Prior art keywords
- sacarinylmethyl
- phosphonates
- methods
- phosphates
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/814,741 US5187173A (en) | 1991-12-27 | 1991-12-27 | 2-saccharinylmethyl and 4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2100274T3 true ES2100274T3 (es) | 1997-06-16 |
Family
ID=25215883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92204032T Expired - Lifetime ES2100274T3 (es) | 1991-12-27 | 1992-12-19 | Nuevos 2-sacarinilmetil y 4,5,6,7-tetrahidro-2-sacarinilmetil fosfatos, fosfonatos y fosfinatos utiles como inhibidores de enzimas proteoliticos y composiciones y metodos de empleo de los mismos. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5187173A (enExample) |
| EP (1) | EP0549073B1 (enExample) |
| JP (1) | JPH05271262A (enExample) |
| AT (1) | ATE150755T1 (enExample) |
| AU (1) | AU648938B2 (enExample) |
| CA (1) | CA2085427A1 (enExample) |
| CZ (1) | CZ371692A3 (enExample) |
| DE (1) | DE69218568T2 (enExample) |
| DK (1) | DK0549073T3 (enExample) |
| ES (1) | ES2100274T3 (enExample) |
| FI (1) | FI925875A7 (enExample) |
| GR (1) | GR3023632T3 (enExample) |
| HU (1) | HUT63630A (enExample) |
| IL (3) | IL104229A (enExample) |
| MX (1) | MX9207542A (enExample) |
| MY (1) | MY106897A (enExample) |
| NO (1) | NO303639B1 (enExample) |
| NZ (1) | NZ245585A (enExample) |
| RU (1) | RU2091377C1 (enExample) |
| SG (1) | SG48310A1 (enExample) |
| SK (1) | SK371692A3 (enExample) |
| TW (1) | TW225538B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5236917A (en) * | 1989-05-04 | 1993-08-17 | Sterling Winthrop Inc. | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| US5296496A (en) * | 1991-12-27 | 1994-03-22 | Sterling Winthrop Inc. | 2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| AU653279B2 (en) * | 1991-12-30 | 1994-09-22 | Sanofi | Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| US5541168A (en) * | 1994-12-02 | 1996-07-30 | Sterling Winthrop Inc. | Substituted 2-(phosphinyloxymethyl)-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof |
| HRP20040800B1 (en) * | 2002-03-05 | 2012-11-30 | Merck Frosst Canada & Co Axys | Cathepsin cysteine protease inhibitors |
| PL372413A1 (en) * | 2002-03-20 | 2005-07-25 | Bristol-Myers Squibb Company | Phosphate prodrugs of fluorooxindoles |
| EA201201550A1 (ru) * | 2005-03-21 | 2013-08-30 | Вайробей, Инк. | Производные альфа-кетоамидов в качестве ингибиторов цистеинпротеаз |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3002884A (en) * | 1959-04-15 | 1961-10-03 | Rohm & Haas | Horticultural process with n-halomethyl-1,2-benzisothiazolin - 3 - one-1,1-dioxides for controlling fungus diseases |
| US3314960A (en) * | 1964-08-25 | 1967-04-18 | American Home Prod | Benzisothiazol glutarimides |
| FR1451417A (fr) * | 1965-07-15 | 1966-01-07 | Roussel Uclaf | Nouveaux esters d'acides cycliques et leur procédé de préparation |
| US4195023A (en) * | 1975-08-20 | 1980-03-25 | Merck & Co., Inc. | 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin |
| US4276298A (en) * | 1978-03-24 | 1981-06-30 | Merck & Co., Inc. | 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors |
| US4263393A (en) * | 1979-09-06 | 1981-04-21 | Eastman Kodak Company | Novel electron donor precursors and photographic element containing them |
| US4350752A (en) * | 1980-12-29 | 1982-09-21 | Eastman Kodak Company | Photographic elements and film units containing imidomethyl blocked photographic reagents |
| US4363865A (en) * | 1981-03-04 | 1982-12-14 | Eastman Kodak Company | Imido methyl blocked photographic dyes and dye releasing compounds |
| US4410618A (en) * | 1982-06-11 | 1983-10-18 | Eastman Kodak Company | Blocked photographic reagents |
| US4623645A (en) * | 1983-04-18 | 1986-11-18 | Merck & Co., Inc. | Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents |
| US4547371A (en) * | 1983-04-18 | 1985-10-15 | Merck & Co., Inc. | Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents |
| US4659855A (en) * | 1983-05-09 | 1987-04-21 | Georgia Tech Research Corporation | Aryl sulfonyl fluoride compounds |
| JPH026496A (ja) * | 1988-06-27 | 1990-01-10 | Ishihara Sangyo Kaisha Ltd | 有機リン酸アミド系化合物、それらの製造方法及びそれらを含有する有害動物防除剤 |
| US5236917A (en) * | 1989-05-04 | 1993-08-17 | Sterling Winthrop Inc. | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| NZ233521A (en) * | 1989-05-04 | 1992-05-26 | Sterling Drug Inc | 2-substituted saccharin derivatives, preparation and pharmaceutical compositions thereof |
| AU642537B2 (en) * | 1990-11-01 | 1993-10-21 | Sanofi | 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
-
1991
- 1991-12-27 US US07/814,741 patent/US5187173A/en not_active Expired - Fee Related
-
1992
- 1992-11-12 AU AU28294/92A patent/AU648938B2/en not_active Ceased
- 1992-11-18 TW TW081109246A patent/TW225538B/zh active
- 1992-12-15 CA CA002085427A patent/CA2085427A1/en not_active Abandoned
- 1992-12-17 CZ CS923716A patent/CZ371692A3/cs unknown
- 1992-12-17 SK SK3716-92A patent/SK371692A3/sk unknown
- 1992-12-19 DE DE69218568T patent/DE69218568T2/de not_active Expired - Fee Related
- 1992-12-19 SG SG1996008831A patent/SG48310A1/en unknown
- 1992-12-19 ES ES92204032T patent/ES2100274T3/es not_active Expired - Lifetime
- 1992-12-19 EP EP92204032A patent/EP0549073B1/en not_active Expired - Lifetime
- 1992-12-19 DK DK92204032.4T patent/DK0549073T3/da active
- 1992-12-19 AT AT92204032T patent/ATE150755T1/de not_active IP Right Cessation
- 1992-12-23 NZ NZ245585A patent/NZ245585A/en unknown
- 1992-12-23 MX MX9207542A patent/MX9207542A/es not_active IP Right Cessation
- 1992-12-23 FI FI925875A patent/FI925875A7/fi unknown
- 1992-12-23 HU HU9204123A patent/HUT63630A/hu unknown
- 1992-12-23 NO NO924991A patent/NO303639B1/no unknown
- 1992-12-24 MY MYPI92002386A patent/MY106897A/en unknown
- 1992-12-25 RU RU9292016280A patent/RU2091377C1/ru active
- 1992-12-25 IL IL10422992A patent/IL104229A/xx not_active IP Right Cessation
- 1992-12-25 IL IL116601A patent/IL116601A/xx not_active IP Right Cessation
- 1992-12-28 JP JP4348373A patent/JPH05271262A/ja not_active Withdrawn
-
1995
- 1995-12-28 IL IL11660195A patent/IL116601A0/xx unknown
-
1997
- 1997-05-30 GR GR970401278T patent/GR3023632T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO924991D0 (no) | 1992-12-23 |
| GR3023632T3 (en) | 1997-08-29 |
| FI925875L (fi) | 1993-06-28 |
| MY106897A (en) | 1995-08-30 |
| DE69218568D1 (de) | 1997-04-30 |
| CA2085427A1 (en) | 1993-06-28 |
| ATE150755T1 (de) | 1997-04-15 |
| HU9204123D0 (en) | 1993-04-28 |
| IL116601A (en) | 1997-04-15 |
| IL116601A0 (en) | 1996-03-31 |
| IL104229A (en) | 1997-02-18 |
| DE69218568T2 (de) | 1997-11-13 |
| JPH05271262A (ja) | 1993-10-19 |
| RU2091377C1 (ru) | 1997-09-27 |
| EP0549073B1 (en) | 1997-03-26 |
| NZ245585A (en) | 1995-05-26 |
| SK371692A3 (en) | 1995-05-10 |
| MX9207542A (es) | 1993-06-01 |
| CZ371692A3 (en) | 1994-04-13 |
| TW225538B (enExample) | 1994-06-21 |
| EP0549073A1 (en) | 1993-06-30 |
| FI925875A7 (fi) | 1993-06-28 |
| NO303639B1 (no) | 1998-08-10 |
| SG48310A1 (en) | 1998-04-17 |
| AU2829492A (en) | 1993-07-01 |
| DK0549073T3 (da) | 1997-10-06 |
| NO924991L (no) | 1993-06-28 |
| HUT63630A (en) | 1993-09-28 |
| IL104229A0 (en) | 1993-05-13 |
| US5187173A (en) | 1993-02-16 |
| AU648938B2 (en) | 1994-05-05 |
| FI925875A0 (fi) | 1992-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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