ES2098191B1 - Procedimiento para la obtencion de tioeteres para uso farmaceutico por metodos electroquimicos. - Google Patents

Procedimiento para la obtencion de tioeteres para uso farmaceutico por metodos electroquimicos.

Info

Publication number
ES2098191B1
ES2098191B1 ES09501098A ES9501098A ES2098191B1 ES 2098191 B1 ES2098191 B1 ES 2098191B1 ES 09501098 A ES09501098 A ES 09501098A ES 9501098 A ES9501098 A ES 9501098A ES 2098191 B1 ES2098191 B1 ES 2098191B1
Authority
ES
Spain
Prior art keywords
thioeter
procedure
obtaining
pharmaceutical use
electrochemical methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09501098A
Other languages
English (en)
Other versions
ES2098191A1 (es
Inventor
Riera Antonio Aldaz
Flores Francisco Carmona
Morales Manuel Esteban
Garcia Vicente Garcia
Garcia Jose Gonzalez
Leguey Vicente Montiel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM DERETIL SA
Deretil SA
Original Assignee
DSM DERETIL SA
DSM Deretil SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM DERETIL SA, DSM Deretil SA filed Critical DSM DERETIL SA
Priority to ES09501098A priority Critical patent/ES2098191B1/es
Priority to ARP960102761A priority patent/AR002125A1/es
Priority to JP8536225A priority patent/JPH10506681A/ja
Priority to EP96914221A priority patent/EP0778360A1/en
Priority to SK125-97A priority patent/SK12597A3/sk
Priority to AU57651/96A priority patent/AU5765196A/en
Priority to CA002196561A priority patent/CA2196561A1/en
Priority to HU9700300A priority patent/HU9700300D0/hu
Priority to BR9606411A priority patent/BR9606411A/pt
Priority to PCT/ES1996/000122 priority patent/WO1996038601A1/es
Publication of ES2098191A1 publication Critical patent/ES2098191A1/es
Application granted granted Critical
Publication of ES2098191B1 publication Critical patent/ES2098191B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/20—Processes
    • C25B3/25—Reduction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE TIOETERES PARA USO FARMACEUTICO POR METODOS ELECTROQUIMICOS. SE OBTIENEN TIOETERES DE FORMULA (I) DONDE R1 ES ALQUILO C2-C5, OPCIONALMENTE SUSTITUIDO, FENILO SUSTITUIDO, FENIL (HALOALQUILO C1-C4), -CH2-COOR3 ES H O UN CATION, HALOFORMILALQUILO O HALOFORMILARILO, Y R2 ES -(CH2)N-CH (NHR4)-COOH, R4 ES H O ACETILO Y N ES 1 O 2, MEDIANTE LA ELECTRORREDUCCION DE UN DISULFURO (II) EN UN MEDIO BASICO AL QUE SE LE ADICIONA UN COMPUESTO (III), DONDE X ES HALOGENO, DE FORMA CONTROLADA, A LO LARGO DEL PROCESO, MANTENIENDO EL PH ENTRE 9 Y 12, EN UNA CELULA ELECTROQUIMICA QUE COMPRENDE AL MENOS, UN CATODO Y UN ANODO, UN CATOLITO Y UN ANOLITO SEPARADOS POR UNA MEMBRANA DE INTERCAMBIO IONICO. LOS TIOETERES (I) OBTENIDOS TIENEN ACTIVIDAD MUCOLITICA, CUMPLEN LAS ESPECIFICACIONES DE LA FARMACOPEA EUROPEA Y SON ADECUADOS PARA SU EMPLEO EN FARMACIA.
ES09501098A 1995-06-01 1995-06-01 Procedimiento para la obtencion de tioeteres para uso farmaceutico por metodos electroquimicos. Expired - Fee Related ES2098191B1 (es)

Priority Applications (10)

Application Number Priority Date Filing Date Title
ES09501098A ES2098191B1 (es) 1995-06-01 1995-06-01 Procedimiento para la obtencion de tioeteres para uso farmaceutico por metodos electroquimicos.
ARP960102761A AR002125A1 (es) 1995-06-01 1996-05-28 Procedimiento para la obtencion de tioeteres para uso farmaceutico por metodos electroquimicos.
EP96914221A EP0778360A1 (en) 1995-06-01 1996-05-29 Process for producing by electrochemical methods thioethers for pharmaceutical use
SK125-97A SK12597A3 (en) 1995-06-01 1996-05-29 Process for producing by electrochemical methods thioethers for pharmaceutical use
AU57651/96A AU5765196A (en) 1995-06-01 1996-05-29 Process for producing by electrochemical methods thioethers for pharmaceutical use
CA002196561A CA2196561A1 (en) 1995-06-01 1996-05-29 Process for producing by electrochemical methods thioethers for pharmaceutical use
JP8536225A JPH10506681A (ja) 1995-06-01 1996-05-29 薬剤用チオエーテルの電気化学的製造法
HU9700300A HU9700300D0 (en) 1995-06-01 1996-05-29 Process for producing by electrochemical methods thioethers for pharmaceutical use
BR9606411A BR9606411A (pt) 1995-06-01 1996-05-29 Processo para obtenção de tioéteres para o uso farmacéutico através de métodos eletroquimicos
PCT/ES1996/000122 WO1996038601A1 (es) 1995-06-01 1996-05-29 Procedimiento para la obtencion de tioeteres para uso farmaceutico por metodos electroquimicos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09501098A ES2098191B1 (es) 1995-06-01 1995-06-01 Procedimiento para la obtencion de tioeteres para uso farmaceutico por metodos electroquimicos.

Publications (2)

Publication Number Publication Date
ES2098191A1 ES2098191A1 (es) 1997-04-16
ES2098191B1 true ES2098191B1 (es) 1997-12-16

Family

ID=8290600

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09501098A Expired - Fee Related ES2098191B1 (es) 1995-06-01 1995-06-01 Procedimiento para la obtencion de tioeteres para uso farmaceutico por metodos electroquimicos.

Country Status (10)

Country Link
EP (1) EP0778360A1 (es)
JP (1) JPH10506681A (es)
AR (1) AR002125A1 (es)
AU (1) AU5765196A (es)
BR (1) BR9606411A (es)
CA (1) CA2196561A1 (es)
ES (1) ES2098191B1 (es)
HU (1) HU9700300D0 (es)
SK (1) SK12597A3 (es)
WO (1) WO1996038601A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2108654B1 (es) * 1996-05-07 1998-07-01 Univ Alicante Procedimiento para la sintesis electroquimica de n-acetilcisteina a partir de cistina.
ES2137105B1 (es) * 1997-03-20 2000-08-16 Dsm Deretil S A Procedimiento para la obtencion de l-cisteinas n-monosustituidas por via electroquimica.
JP5186049B1 (ja) * 2012-02-23 2013-04-17 実 金松 シリンダ付ホルダ及び把捉機構付ホルダ
CN105418471B (zh) * 2015-12-24 2017-09-05 宜昌三峡制药有限公司 一种羧甲司坦的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE550900A (es) * 1955-11-29
GB8601582D0 (en) * 1986-01-23 1986-02-26 Electricity Council Production of l-cysteine
US5106463A (en) * 1988-08-15 1992-04-21 The Electrosynthesis Company, Inc. High yield methods for electrochemical preparation of cysteine and analogues
EP0436055A1 (en) * 1990-01-04 1991-07-10 The Electrosynthesis Company, Inc. High yield methods for electrochemical preparation of cysteine and analogues
ES2032155A6 (es) * 1990-04-06 1993-01-01 Almu S A Procedimiento de obtencion de l-carboximetil-cisteina a partir de l-cisteina por metodos electroquimicos.

Also Published As

Publication number Publication date
CA2196561A1 (en) 1996-12-05
AU5765196A (en) 1996-12-18
HU9700300D0 (en) 1997-04-28
BR9606411A (pt) 1997-12-30
JPH10506681A (ja) 1998-06-30
EP0778360A1 (en) 1997-06-11
AR002125A1 (es) 1998-01-07
SK12597A3 (en) 1997-08-06
WO1996038601A1 (es) 1996-12-05
ES2098191A1 (es) 1997-04-16

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