ES2098164T3 - Mezcla sinergetica de al menos un ligando especifico de los rxrs y al menos un ligando especifico de rar-alfa. - Google Patents
Mezcla sinergetica de al menos un ligando especifico de los rxrs y al menos un ligando especifico de rar-alfa.Info
- Publication number
- ES2098164T3 ES2098164T3 ES95401477T ES95401477T ES2098164T3 ES 2098164 T3 ES2098164 T3 ES 2098164T3 ES 95401477 T ES95401477 T ES 95401477T ES 95401477 T ES95401477 T ES 95401477T ES 2098164 T3 ES2098164 T3 ES 2098164T3
- Authority
- ES
- Spain
- Prior art keywords
- league
- rxrs
- rar
- specific league
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002195 synergetic effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 2
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Catalysts (AREA)
- Detergent Compositions (AREA)
- Materials For Medical Uses (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA INVENCION SE REFIERE A LA UTILIZACION DE NUEVAS ASOCIACIONES A BASE DE AL MENOS UN PRIMER LIGANDO QUE PRESENTA UNA ACTIVIDAD SELECTIVA PARA LOS RECEPTORES RXRS Y POR AL MENOS UN SEGUNDO LIGANDO QUE PRESENTA UNA ACTIVIDAD SELECTIVA PARA EL RECEPTOR RAR-ALFA, COMO PRINCIPIOS ACTIVOS EN, O PARA LA FABRICACION DE, COMPOSICIONES FARMACEUTICAS Y/O DERMATOLOGICAS MAS PARTICULARMENTE DESTINADAS A MODULAR LA PROLIFERACION Y/O LA DIFERENCIACION DE UN SISTEMA CELULAR DE TIPO HL-60, CON EL OBJETIVO PARTICULARMENTE DE TRATAR, POR VIA SISTEMICA, LA LEUCEMIA PROMIELOCITARIA AGUDA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9409307A FR2722985B1 (fr) | 1994-07-27 | 1994-07-27 | Nouvelles compositions a base d'un melange synergetique entre au moins un ligand specifique des rxrs et au moins un ligand specifique de rar-x ou de vdr, et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2098164T3 true ES2098164T3 (es) | 1997-04-16 |
Family
ID=9465802
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95401477T Expired - Lifetime ES2098164T3 (es) | 1994-07-27 | 1995-06-21 | Mezcla sinergetica de al menos un ligando especifico de los rxrs y al menos un ligando especifico de rar-alfa. |
Country Status (19)
Country | Link |
---|---|
US (1) | US5767148A (es) |
EP (1) | EP0694301B1 (es) |
JP (1) | JP2783521B2 (es) |
KR (1) | KR0168727B1 (es) |
AT (1) | ATE145134T1 (es) |
AU (1) | AU674479B2 (es) |
BR (1) | BR9502338A (es) |
CA (1) | CA2154730C (es) |
DE (1) | DE69500085T2 (es) |
ES (1) | ES2098164T3 (es) |
FI (1) | FI953567A (es) |
FR (1) | FR2722985B1 (es) |
HU (1) | HUT73793A (es) |
IL (1) | IL114765A (es) |
NO (1) | NO952944L (es) |
NZ (1) | NZ272527A (es) |
PL (1) | PL181061B1 (es) |
RU (1) | RU2120304C1 (es) |
ZA (1) | ZA955537B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2735370B1 (fr) * | 1995-06-19 | 1997-07-18 | Cird Galderma | Procede pour identifier des composes agonistes des recepteurs rxrs |
FR2735367B1 (fr) * | 1995-06-19 | 1997-07-18 | Cird Galderma | Utilisation de ligands specifiques des recepteurs rxrs |
FR2739777B1 (fr) * | 1995-10-11 | 1997-11-14 | Cird Galderma | Ligand antagoniste rar-gamma ou agoniste rar-alpha en tant qu'inhibiteur d'apoptose |
FR2753091B1 (fr) * | 1996-09-09 | 2001-03-16 | Oreal | Utilisation d'un agoniste des recepteurs des retinoides de type rxr pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute |
JP2001522350A (ja) * | 1997-04-11 | 2001-11-13 | シドニー キメル キャンサー センター | 疾患におけるエンドセリン−1の過剰産生の阻害のためのレチノイド関連分子 |
CA2295807A1 (en) * | 1997-07-29 | 1999-02-11 | Bristol-Myers Squibb Company | Use of selective rxr agonists to prevent surgical adhesions |
FR2779720B1 (fr) * | 1998-06-12 | 2002-08-16 | Galderma Rech Dermatologique | Nouveaux composes diarylselenures et leur utilisation en medecine humaine ou veterinaire ainsi qu'en cosmetologie |
US6436993B1 (en) * | 1999-07-13 | 2002-08-20 | The Salk Institute For Biological Studies | Use of RAR antagonists as modulators of hormone mediated processes |
US6904229B1 (en) * | 1999-08-20 | 2005-06-07 | Canon Kabushiki Kaisha | Apparatus for recording signals on disk recording medium |
CN100388532C (zh) * | 2005-09-28 | 2008-05-14 | 浙江工业大学 | 一种锂二次电池的隔膜添加剂及锂二次电池隔膜 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE208194T1 (de) * | 1991-08-23 | 2001-11-15 | Salk Inst For Biological Studi | Verwendung von selektiven liganden zur behandlung von hormonansprechenden krankheitzuständen |
ES2149814T3 (es) * | 1992-04-22 | 2000-11-16 | Ligand Pharm Inc | Compuestos que tienen selectividad para los receptores de retinoides x. |
-
1994
- 1994-07-27 FR FR9409307A patent/FR2722985B1/fr not_active Expired - Fee Related
-
1995
- 1995-06-21 AT AT95401477T patent/ATE145134T1/de not_active IP Right Cessation
- 1995-06-21 EP EP95401477A patent/EP0694301B1/fr not_active Expired - Lifetime
- 1995-06-21 ES ES95401477T patent/ES2098164T3/es not_active Expired - Lifetime
- 1995-06-21 DE DE69500085T patent/DE69500085T2/de not_active Expired - Fee Related
- 1995-06-27 AU AU23279/95A patent/AU674479B2/en not_active Ceased
- 1995-07-04 ZA ZA955537A patent/ZA955537B/xx unknown
- 1995-07-07 NZ NZ272527A patent/NZ272527A/en unknown
- 1995-07-12 BR BR9502338A patent/BR9502338A/pt active Search and Examination
- 1995-07-21 JP JP7185956A patent/JP2783521B2/ja not_active Expired - Fee Related
- 1995-07-25 KR KR1019950022143A patent/KR0168727B1/ko not_active IP Right Cessation
- 1995-07-25 NO NO952944A patent/NO952944L/no not_active Application Discontinuation
- 1995-07-26 RU RU95113115A patent/RU2120304C1/ru not_active IP Right Cessation
- 1995-07-26 HU HU9502241A patent/HUT73793A/hu unknown
- 1995-07-26 FI FI953567A patent/FI953567A/fi not_active IP Right Cessation
- 1995-07-26 CA CA002154730A patent/CA2154730C/fr not_active Expired - Fee Related
- 1995-07-26 PL PL95309772A patent/PL181061B1/pl not_active IP Right Cessation
- 1995-07-27 IL IL11476595A patent/IL114765A/xx not_active IP Right Cessation
- 1995-07-27 US US08/507,913 patent/US5767148A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FR2722985A1 (fr) | 1996-02-02 |
IL114765A0 (en) | 1995-11-27 |
AU2327995A (en) | 1996-02-08 |
ZA955537B (en) | 1996-02-16 |
IL114765A (en) | 2000-06-01 |
DE69500085D1 (de) | 1996-12-19 |
EP0694301B1 (fr) | 1996-11-13 |
CA2154730C (fr) | 2000-02-15 |
FI953567A (fi) | 1996-01-28 |
HU9502241D0 (en) | 1995-09-28 |
FR2722985B1 (fr) | 1996-09-13 |
JPH0859511A (ja) | 1996-03-05 |
NZ272527A (en) | 1997-01-29 |
EP0694301A1 (fr) | 1996-01-31 |
FI953567A0 (fi) | 1995-07-26 |
CA2154730A1 (fr) | 1996-01-28 |
KR0168727B1 (ko) | 1999-01-15 |
KR960003721A (ko) | 1996-02-23 |
NO952944D0 (no) | 1995-07-25 |
RU2120304C1 (ru) | 1998-10-20 |
NO952944L (no) | 1996-01-29 |
BR9502338A (pt) | 1996-02-27 |
AU674479B2 (en) | 1996-12-19 |
US5767148A (en) | 1998-06-16 |
JP2783521B2 (ja) | 1998-08-06 |
PL181061B1 (pl) | 2001-05-31 |
PL309772A1 (en) | 1996-02-05 |
HUT73793A (en) | 1996-09-30 |
DE69500085T2 (de) | 1997-03-06 |
ATE145134T1 (de) | 1996-11-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR008991A1 (es) | Compuestos de dimetil-(3-aril-but-3-enil)-amina, procedimientos para su preparacion y aplicacion de los mismos | |
ES2126766T3 (es) | 7-azaindol-3-ilcarboxiamidas de tropilo como agente antitusivo. | |
ES2191192T3 (es) | Tienopirimidinas. | |
ES2070253T3 (es) | Ciclohexanoles sustituidos utiles como agentes para el sistema nervioso central. | |
BR0314356A (pt) | Formulações de liberação retardada para administração oral de um agente terapêutico polipetìdeo e métodos utilizando as mesmas | |
CR9430A (es) | N-hidroxiamidas omega-sustituidas con grupos triciclos como inhibidores de histona desacetilasa, su preparacion y uso en formulaciones farmaceuticas | |
ES2184149T3 (es) | Paclitaxeles 6-tio sustituidos. | |
BRPI0409133A (pt) | formulações farmacêuticas contendo metilnaltrexona | |
GT200500007A (es) | [1,8]naftiridin-2-onas y compuestos relacionados para el tratamiento de la esquizofrenia. | |
BR9713734A (pt) | Derivados de sulfonamidas, processo para sua preparação, e seu uso como medicamentos | |
ES2156603T3 (es) | Medicamentos a base de una mezcla sinergetica de metronidazol y de clindamicina. | |
ES2153907T3 (es) | Compuestos espiro tetraciclicos, procedimiento para su preparacion y su uso como antagonistas del receptor 5ht1d. | |
BR9801652A (pt) | Resorcinil-triazinas | |
ES2098164T3 (es) | Mezcla sinergetica de al menos un ligando especifico de los rxrs y al menos un ligando especifico de rar-alfa. | |
BR9909486A (pt) | Compostos calcilìticos | |
PA8577201A1 (es) | 3-fenil-propionamido, 3-fenil-acrilamido y derivados 3-fenil-propinamido como inhibidores de mao-b | |
ES2178055T3 (es) | Derivados aminicos substituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
ES2139965T3 (es) | Benzoilguanidinas sustituidas con grupos de caracter basico, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene. | |
UY27662A1 (es) | Inhibidores de la mocroglia para interrumpir reacciones inmunes asociadas con interleucina 12 y ifny. | |
ES2052484T1 (es) | N-(5-tioxo-l-prolil)-l-cisteina, sus derivados, procedimientos para su preparacion y composiciones farmaceuticas que los contienen. | |
AR002272A1 (es) | Uso de amidas de fenilciclohexilcarboxilicos | |
ES2129893T3 (es) | Dinucleosido-5',5'-pirofosfatos. | |
AR005704A1 (es) | Heteroariloxazolidinonas | |
BR9802803A (pt) | ação e composições farmacêuticas contendo os mesmos. | |
ES2133918T3 (es) | Nuevos esteroides seco-d activos en el sistema cardiovascular y composiciones farmaceuticas que los contienen. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 694301 Country of ref document: ES |