ES2097269T3 - Metodo para cristalizar ester metilico de alfa-l-aspartil-l-fenilalanina. - Google Patents

Metodo para cristalizar ester metilico de alfa-l-aspartil-l-fenilalanina.

Info

Publication number
ES2097269T3
ES2097269T3 ES92202214T ES92202214T ES2097269T3 ES 2097269 T3 ES2097269 T3 ES 2097269T3 ES 92202214 T ES92202214 T ES 92202214T ES 92202214 T ES92202214 T ES 92202214T ES 2097269 T3 ES2097269 T3 ES 2097269T3
Authority
ES
Spain
Prior art keywords
crystals
apm
methyl ester
crushed
phenylalanine methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92202214T
Other languages
English (en)
Inventor
Tsuguo Murakami
Winfried Johannes Wout Vermijs
Hidetaka Egashira
Kengo Okajima
Hidetoshi Wakamatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Holland Sweetener Co VOF
Original Assignee
Holland Sweetener Co VOF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP32985191A external-priority patent/JP3291747B2/ja
Application filed by Holland Sweetener Co VOF filed Critical Holland Sweetener Co VOF
Application granted granted Critical
Publication of ES2097269T3 publication Critical patent/ES2097269T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

UN METODO PARA CRISTALIZAR UN ESTER ALFA L FENILALANINA METILO (APM) MEDIANTE ENFRIAMIENTO. EN ESTE METODO, LOS CRISTALES DE APM SE SOMETEN A TRITURACION Y LOS CRISTALES DE APM TRITURADOS SE UTILIZAN COMO CRISTALES SEMILLA PARA CULTIVAR CRISTALES DE APM. MEDIANTE EL USO DE CRISTALES SEMILLA TRITURADOS, SE PUEDE SUPRIMIR LA GENERACION DE CRISTALES APM SECUNDARIOS, Y LA RELACION ANCHURA A LONGITUD DE LOS CRISTALES APM RESULTANTES SE HACE MAYOR. EN TOTAL, SE PUEDEN OBTENER GRANDES CRISTALES APM, QUE POSEEN PROPIEDADES DE SECADO Y FILTRADO MEJORADAS. DICHOS CRISTALES PUEDEN POSEER VENTAJAS EN CUANTO A PRODUCCION, CALIDAD Y MANIPULACION. LA PRECIPITACION DE CRISTALES APM SE PRODUCE CON BASTANTE EFICACIA CON SOLO UNA PEQUEÑA CANTIDAD DE CRISTALES SEMILLA TRITURADOS. ESTE INVENTO TAMBIEN SE REFIERE A LA CRISTALIZACION DE APM UTILIZANDO IN SITU CRISTALES SEMILLA TRITURADOS PREPARADOS.
ES92202214T 1991-07-19 1992-07-17 Metodo para cristalizar ester metilico de alfa-l-aspartil-l-fenilalanina. Expired - Lifetime ES2097269T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP20370391 1991-07-19
JP21046991 1991-07-29
JP32985191A JP3291747B2 (ja) 1991-07-29 1991-11-19 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの晶析方法

Publications (1)

Publication Number Publication Date
ES2097269T3 true ES2097269T3 (es) 1997-04-01

Family

ID=27328272

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92202214T Expired - Lifetime ES2097269T3 (es) 1991-07-19 1992-07-17 Metodo para cristalizar ester metilico de alfa-l-aspartil-l-fenilalanina.

Country Status (7)

Country Link
EP (1) EP0533222B1 (es)
KR (1) KR930702385A (es)
AT (1) ATE145920T1 (es)
CA (1) CA2089358A1 (es)
DE (1) DE69215618T2 (es)
ES (1) ES2097269T3 (es)
WO (1) WO1993002101A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0733641A1 (en) * 1995-03-20 1996-09-25 Holland Sweetener Company V.O.F. Method for crystallizing alpha-l-aspartyl-l-phenylalanine methyl ester
CA2172022A1 (en) * 1995-03-20 1996-09-21 Tsugio Murakami Method for crystallizing alpha-l-aspartyl-l-phenylalanine methyl ester
CA2348021A1 (en) * 1998-10-30 2000-05-11 Ajinomoto Co., Inc. Crystallization processes for the formation of stable crystals of aspartame derivative
CN1413218A (zh) * 1999-12-28 2003-04-23 味之素株式会社 天冬甜素衍生物的结晶

Also Published As

Publication number Publication date
EP0533222B1 (en) 1996-12-04
EP0533222A1 (en) 1993-03-24
DE69215618T2 (de) 1997-07-03
DE69215618D1 (de) 1997-01-16
ATE145920T1 (de) 1996-12-15
CA2089358A1 (en) 1993-01-20
KR930702385A (ko) 1993-09-08
WO1993002101A1 (en) 1993-02-04

Similar Documents

Publication Publication Date Title
EA200001221A1 (ru) Новая форма ирбесартана, способы получения указанной формы и содержащие ее фармацевтические композиции
DE2508803A1 (de) Neuartige siliciumkristalle und verfahren zu ihrer herstellung
DE1291320B (de) Verfahren zum Ziehen dendritischer Kristalle
ES2097269T3 (es) Metodo para cristalizar ester metilico de alfa-l-aspartil-l-fenilalanina.
EP1201793A4 (en) PROCESS AND APPARATUS FOR MANUFACTURING HIGH QUALITY MONOCRYSTALS
Zaccaro et al. Crystal growth of hybrid nonlinear optical materials: 2-amino-5-nitropyridinium dihydrogenphosphate and dihydrogenarsenate
DE2726744C3 (de) Einkristallines Substrat aus Calcium-Gallium-Granat sowie mit diesem hergestellte magnetische Blasendomänenanordnung
RU93005123A (ru) Способ кристаллизации метилового эфира альфа-1-аспартил-1-фенилаланина
Mizuno Studies of crystal imperfections in ice with reference to the growth process by the use of X-ray diffraction topography and divergent Laue method
MY133116A (en) Process for preparing defect free silicon crystals which allows for variability in process conditions
DE69521110D1 (de) Crystallisierung vom Alpha-L-Aspartyl-L-phenylalanylmethylester aus wässrigen Lösungen
RU1732701C (ru) Способ получения затравочной пластины
DE2535160A1 (de) Verfahren und vorrichtung zum zuechten von kristallen
Raman et al. Growth of antimony sulphoiodide in gel
Mahtab et al. Phosphorus diffusion in soils: II. The effect on phosphorus uptake by plants
HK1057066A1 (en) Method for producing s crystalline tableting additive, additive thus obtained and use thereof
JPS5792599A (en) Production of single crystal of ferrite
JPS5435899A (en) Production of rare earth element gallium garnet single crystal
Rashkovich Effect of pH on the growth of KDP
SU571295A1 (ru) Способ получени мультикристаллов
JPS5228258A (en) Method for growth of crystals from liquid phase
FEIGELSON Phase equilibrium and crystal growth studies on AgGaSe 2 and related nonlinear optical materials(Progress Report, 1 Jul.- 31 Dec. 1987)
JPS52149273A (en) Production of plate-shaped crystal
JPS56109900A (en) Growing method for rare earth element aluminate single crystal
Bolotov et al. New Crystal Defect Structure Types Detectable by Electron Microscopy.(Retroactive Coverage)

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 533222

Country of ref document: ES