ES2097269T3 - Metodo para cristalizar ester metilico de alfa-l-aspartil-l-fenilalanina. - Google Patents
Metodo para cristalizar ester metilico de alfa-l-aspartil-l-fenilalanina.Info
- Publication number
- ES2097269T3 ES2097269T3 ES92202214T ES92202214T ES2097269T3 ES 2097269 T3 ES2097269 T3 ES 2097269T3 ES 92202214 T ES92202214 T ES 92202214T ES 92202214 T ES92202214 T ES 92202214T ES 2097269 T3 ES2097269 T3 ES 2097269T3
- Authority
- ES
- Spain
- Prior art keywords
- crystals
- apm
- methyl ester
- crushed
- phenylalanine methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
UN METODO PARA CRISTALIZAR UN ESTER ALFA L FENILALANINA METILO (APM) MEDIANTE ENFRIAMIENTO. EN ESTE METODO, LOS CRISTALES DE APM SE SOMETEN A TRITURACION Y LOS CRISTALES DE APM TRITURADOS SE UTILIZAN COMO CRISTALES SEMILLA PARA CULTIVAR CRISTALES DE APM. MEDIANTE EL USO DE CRISTALES SEMILLA TRITURADOS, SE PUEDE SUPRIMIR LA GENERACION DE CRISTALES APM SECUNDARIOS, Y LA RELACION ANCHURA A LONGITUD DE LOS CRISTALES APM RESULTANTES SE HACE MAYOR. EN TOTAL, SE PUEDEN OBTENER GRANDES CRISTALES APM, QUE POSEEN PROPIEDADES DE SECADO Y FILTRADO MEJORADAS. DICHOS CRISTALES PUEDEN POSEER VENTAJAS EN CUANTO A PRODUCCION, CALIDAD Y MANIPULACION. LA PRECIPITACION DE CRISTALES APM SE PRODUCE CON BASTANTE EFICACIA CON SOLO UNA PEQUEÑA CANTIDAD DE CRISTALES SEMILLA TRITURADOS. ESTE INVENTO TAMBIEN SE REFIERE A LA CRISTALIZACION DE APM UTILIZANDO IN SITU CRISTALES SEMILLA TRITURADOS PREPARADOS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20370391 | 1991-07-19 | ||
JP21046991 | 1991-07-29 | ||
JP32985191A JP3291747B2 (ja) | 1991-07-29 | 1991-11-19 | α−L−アスパルチル−L−フェニルアラニンメチルエステルの晶析方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2097269T3 true ES2097269T3 (es) | 1997-04-01 |
Family
ID=27328272
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92202214T Expired - Lifetime ES2097269T3 (es) | 1991-07-19 | 1992-07-17 | Metodo para cristalizar ester metilico de alfa-l-aspartil-l-fenilalanina. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0533222B1 (es) |
KR (1) | KR930702385A (es) |
AT (1) | ATE145920T1 (es) |
CA (1) | CA2089358A1 (es) |
DE (1) | DE69215618T2 (es) |
ES (1) | ES2097269T3 (es) |
WO (1) | WO1993002101A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2172022A1 (en) * | 1995-03-20 | 1996-09-21 | Tsugio Murakami | Method for crystallizing alpha-l-aspartyl-l-phenylalanine methyl ester |
EP0733641A1 (en) * | 1995-03-20 | 1996-09-25 | Holland Sweetener Company V.O.F. | Method for crystallizing alpha-l-aspartyl-l-phenylalanine methyl ester |
CN1317012A (zh) | 1998-10-30 | 2001-10-10 | 味之素株式会社 | 稳定性优良的天冬甜素衍生物晶体的结晶方法 |
KR20020063609A (ko) * | 1999-12-28 | 2002-08-03 | 아지노모토 가부시키가이샤 | 아스파탐 유도체 결정 |
-
1992
- 1992-07-17 AT AT92202214T patent/ATE145920T1/de not_active IP Right Cessation
- 1992-07-17 EP EP92202214A patent/EP0533222B1/en not_active Expired - Lifetime
- 1992-07-17 DE DE69215618T patent/DE69215618T2/de not_active Expired - Fee Related
- 1992-07-17 ES ES92202214T patent/ES2097269T3/es not_active Expired - Lifetime
- 1992-07-20 CA CA002089358A patent/CA2089358A1/en not_active Abandoned
- 1992-07-20 WO PCT/JP1992/000924 patent/WO1993002101A1/en active Application Filing
- 1992-07-20 KR KR1019930700823A patent/KR930702385A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2089358A1 (en) | 1993-01-20 |
ATE145920T1 (de) | 1996-12-15 |
EP0533222A1 (en) | 1993-03-24 |
WO1993002101A1 (en) | 1993-02-04 |
KR930702385A (ko) | 1993-09-08 |
DE69215618D1 (de) | 1997-01-16 |
DE69215618T2 (de) | 1997-07-03 |
EP0533222B1 (en) | 1996-12-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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