ES2094815T3 - Composicion terapeutica y proceso para su preparacion. - Google Patents
Composicion terapeutica y proceso para su preparacion.Info
- Publication number
- ES2094815T3 ES2094815T3 ES91913139T ES91913139T ES2094815T3 ES 2094815 T3 ES2094815 T3 ES 2094815T3 ES 91913139 T ES91913139 T ES 91913139T ES 91913139 T ES91913139 T ES 91913139T ES 2094815 T3 ES2094815 T3 ES 2094815T3
- Authority
- ES
- Spain
- Prior art keywords
- active substance
- pct
- cover layer
- matrix
- colon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE PRESENTA UNA COMPOSICION FARMACEUTICA SELECTIVA PARA EL COLON PARA EL SUMINISTRO ORAL DE UNA O MAS SUBSTANCIAS TERAPEUTICAMENTE ACTIVAS, LA COMPOSICION COMPRENDE I) UN NUCLEO DE MATRIZ QUE TIENE LA SUBSTANCIA O SUBSTANCIAS ACTIVAS DISPERSAS EN EL MISMO, Y II) UNA CAPA DE CUBIERTA EXTERIOR SIN NINGUNA SUBSTANCIA ACTIVA, DICHO NUCLEO EN FORMA DE MATRIZ Y LA CAPA DE CUBIERTA SON SELECTIVAMENTE DEGRADABLES POR ENZIMAS QUE NORMALMENTE EXISTEN EN EL COLON. UN METODO PARA PREPARAR DICHA COMPOSICION FARMACEUTICA SELECTIVA PARA EL COLON COMPRENDE LOS PASOS DE MEZCLAR AL MENOS UNA SUBSTANCIA TERAPEUTICAMENTE ACTIVA CON UN MATERIAL DE MATRIZ PARA PREPARAR UN NUCLEO DE MATRIZ QUE TENGA LA SUBSTANCIA O SUBSTANCIAS ACTIVAS DISPERSAS EN EL MISMO, Y RECUBRIR DICHO NUCLEO DE MATRIZ CON UN MATERIAL SIN NINGUNA SUBSTANCIA ACTIVA EN EL MISMO PARA PROVEER AL NUCLEO DE MATRIZ DE UNA CAPA DE CUBIERTA PROTECTORA LIBRE DE DROGAS, DICHOS MATERIALES DE MATRIZ Y DE CUBIERTA ESTAN BASADOS EN AL MENOS UNA SUBSTANCIAQUE ES SELECTIVAMENTE DEGRADABLE POR ENZIMAS QUE SE ENCUENTRAN EN EL COLON.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9002339A SE9002339L (sv) | 1990-07-04 | 1990-07-04 | Terapeutisk komposition och foerfarande foer dess framstaellning |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2094815T3 true ES2094815T3 (es) | 1997-02-01 |
Family
ID=20379936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91913139T Expired - Lifetime ES2094815T3 (es) | 1990-07-04 | 1991-07-03 | Composicion terapeutica y proceso para su preparacion. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5505966A (es) |
EP (1) | EP0610178B1 (es) |
JP (1) | JPH05508156A (es) |
AT (1) | ATE145132T1 (es) |
AU (1) | AU8227291A (es) |
DE (1) | DE69123159T2 (es) |
DK (1) | DK0610178T3 (es) |
ES (1) | ES2094815T3 (es) |
GR (1) | GR3022337T3 (es) |
SE (1) | SE9002339L (es) |
WO (1) | WO1992000732A1 (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK89592D0 (da) * | 1992-07-07 | 1992-07-07 | Helle Broendsted | Laegemiddelafgivelsesindretning samt fremgangsmaade til fremstilling deraf |
ES2068154B1 (es) * | 1993-07-13 | 1995-11-16 | Cantabria Ind Farmaceutica Sa | Nuevas formulaciones analgesicas con amplio intervalo de accion. |
ES2068762B1 (es) * | 1993-07-21 | 1995-12-01 | Lipotec Sa | Un nuevo preparado farmaceutico para mejorar la biodisponibilidad de drogas de dificil absorcion y procedimiento para su obtencion. |
DE4331539A1 (de) * | 1993-09-17 | 1995-03-23 | Basf Ag | Dextranester, Verfahren zu ihrer Herstellung und ihre Verwendung zur Umhüllung oder Einbettung von Arzneimitteln |
US5840860A (en) * | 1993-11-17 | 1998-11-24 | Commonwealth Scientific And Industrial Research Organization | Fatty acid delivery system comprising a hydrolyzable bond |
US5849327A (en) * | 1994-07-29 | 1998-12-15 | Advanced Polymer Systems, Inc. | Delivery of drugs to the lower gastrointestinal tract |
US5656294A (en) * | 1995-06-07 | 1997-08-12 | Cibus Pharmaceutical, Inc. | Colonic delivery of drugs |
US5811388A (en) * | 1995-06-07 | 1998-09-22 | Cibus Pharmaceutical, Inc. | Delivery of drugs to the lower GI tract |
US5840332A (en) * | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
US6231888B1 (en) | 1996-01-18 | 2001-05-15 | Perio Products Ltd. | Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps |
AU1751997A (en) * | 1996-01-30 | 1997-08-22 | Advanced Polymer Systems Inc. | Targeted delivery of drugs to the lower gastrointestinal tract |
US6764690B2 (en) * | 1996-05-29 | 2004-07-20 | Delsitech Oy | Dissolvable oxides for biological applications |
KR100219918B1 (ko) | 1997-07-03 | 1999-09-01 | 김윤 | 대장선택적 약물전달용 조성물 |
DE19732903A1 (de) * | 1997-07-30 | 1999-02-04 | Falk Pharma Gmbh | Pellet-Formulierung zur Behandlung des Intestinaltraktes |
US7022683B1 (en) | 1998-05-13 | 2006-04-04 | Carrington Laboratories, Inc. | Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation |
KR20000011247A (ko) * | 1998-07-23 | 2000-02-25 | 김윤 | 다당류를이용한대장선택성약물전달조성물및약학제제 |
DK1146862T3 (da) | 1999-01-29 | 2003-07-21 | Disphar Int Bv | Farmaceutiske sammensætninger |
CN1285333C (zh) * | 2000-06-07 | 2006-11-22 | 张昊 | 结肠定位释放的口服制剂及其制备方法 |
US6720005B1 (en) | 2000-07-07 | 2004-04-13 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Coated, platform-generating tablet |
EP1174127A1 (en) * | 2000-07-21 | 2002-01-23 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Composition for targeted release of an actvie substance and process for producing such a composition |
ES2294026T3 (es) * | 2000-09-06 | 2008-04-01 | Ap Pharma, Inc. | Polimeros degradables de poliacetal. |
US7494669B2 (en) * | 2001-02-28 | 2009-02-24 | Carrington Laboratories, Inc. | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides |
US6777000B2 (en) * | 2001-02-28 | 2004-08-17 | Carrington Laboratories, Inc. | In-situ gel formation of pectin |
US20030152630A1 (en) * | 2001-05-11 | 2003-08-14 | Ng Steven Y. | PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers |
US6590059B2 (en) * | 2001-05-11 | 2003-07-08 | Ap Pharma, Inc. | Bioerodible polyorthoesters from dioxolane-based diketene acetals |
US6524606B1 (en) * | 2001-11-16 | 2003-02-25 | Ap Pharma, Inc. | Bioerodible polyorthoesters containing amine groups |
US20030133982A1 (en) * | 2001-12-20 | 2003-07-17 | Heimlich John M. | Zero-order sustained release dosage forms and method of making same |
FR2843302B1 (fr) * | 2002-08-09 | 2004-10-22 | Centre Nat Rech Scient | Forme galenique pour la delivrance colique de principes actifs |
FR2843301B1 (fr) * | 2002-08-09 | 2004-10-22 | Centre Nat Rech Scient | Forme galenique pour la delivrance colique de principes actifs |
BR0315731A (pt) * | 2002-10-30 | 2005-09-06 | Pharmacia Corp | Comprimidos orais de liberação prolongada e métodos para fabricar e usar os mesmos |
US7737133B2 (en) | 2003-09-03 | 2010-06-15 | Agi Therapeutics Ltd. | Formulations and methods of treating inflammatory bowel disease |
US7825106B2 (en) * | 2003-09-03 | 2010-11-02 | Agi Therapeutics Ltd. | Modified release formulations and methods of treating inflammatory bowel disease |
US20070258879A1 (en) * | 2005-12-13 | 2007-11-08 | Philip Morris Usa Inc. | Carbon beads with multimodal pore size distribution |
US8273376B2 (en) | 2006-11-17 | 2012-09-25 | Da Volterra | Colonic delivery of metallo-dependent enzymes |
US20090269405A1 (en) * | 2008-04-08 | 2009-10-29 | Appian Labs, Llc | Enzyme mediated delivery system |
ZA200903858B (en) * | 2008-06-19 | 2013-10-30 | Univ Of Witwatesrand Johannesburg | Pharmaceutical dosage form |
CZ302789B6 (cs) * | 2009-11-25 | 2011-11-09 | Zentiva, K. S. | Zpusob zvýšení rozpustnosti farmaceuticky aktivních látek a cílený (kontrolovaný) transport do streva |
JP2019513146A (ja) * | 2016-03-30 | 2019-05-23 | バイタル ビバレッジズ グローバル インコーポレーテッド | 選択的gi管送達のための組成物および方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3959457A (en) * | 1970-06-05 | 1976-05-25 | Temple University | Microparticulate material and method of making such material |
US4024073A (en) * | 1972-01-08 | 1977-05-17 | Toray Industries, Inc. | Hydrogel and production thereof |
US3946110A (en) * | 1974-05-30 | 1976-03-23 | Peter, Strong Research And Development Company, Inc. | Medicinal compositions and methods of preparing the same |
US4042073A (en) * | 1976-05-27 | 1977-08-16 | Dana Corporation | Disc brake mechanism actuating means |
US4507327A (en) * | 1983-05-23 | 1985-03-26 | Q.P. Corporation | Process for preparing edible products in the form of capsules |
US4695463A (en) * | 1985-05-24 | 1987-09-22 | Warner-Lambert Company | Delivery system for active ingredients and preparation thereof |
SE459005B (sv) * | 1985-07-12 | 1989-05-29 | Aake Rikard Lindahl | Saett att framstaella sfaeriska polymerpartiklar |
DE3601132A1 (de) * | 1986-01-16 | 1987-07-23 | Christian Bannert | Verfahren zur behandlung der schleimhaut |
FR2608456B1 (fr) * | 1986-12-18 | 1993-06-18 | Mero Rousselot Satia | Microcapsules a base de gelatine et de polysaccharides et leur procede d'obtention |
US4915948A (en) * | 1987-08-31 | 1990-04-10 | Warner-Lambert Company | Tablets having improved bioadhesion to mucous membranes |
US4965252A (en) * | 1988-06-28 | 1990-10-23 | Hauser-Kuhrts, Inc. | Cholesterol-lowering combination compositions of guar gum and niacin |
WO1989008446A1 (en) * | 1988-03-09 | 1989-09-21 | Snow Brand Milk Products Co., Ltd. | Suspended-release preparation prepared by using alginic acid |
FR2645439B1 (fr) * | 1989-04-07 | 1991-06-21 | Oreal | Procede de preparation de capsules d'alginate(s) particulierement adaptees a un usage cosmetique, appareil pour sa mise en oeuvre et composition cosmetique contenant lesdites capsules |
-
1990
- 1990-07-04 SE SE9002339A patent/SE9002339L/ not_active Application Discontinuation
-
1991
- 1991-07-03 JP JP91512398A patent/JPH05508156A/ja active Pending
- 1991-07-03 DE DE69123159T patent/DE69123159T2/de not_active Expired - Fee Related
- 1991-07-03 WO PCT/SE1991/000475 patent/WO1992000732A1/en active IP Right Grant
- 1991-07-03 EP EP91913139A patent/EP0610178B1/en not_active Expired - Lifetime
- 1991-07-03 DK DK91913139.1T patent/DK0610178T3/da active
- 1991-07-03 AT AT91913139T patent/ATE145132T1/de not_active IP Right Cessation
- 1991-07-03 AU AU82272/91A patent/AU8227291A/en not_active Abandoned
- 1991-07-03 US US07/958,369 patent/US5505966A/en not_active Expired - Fee Related
- 1991-07-03 ES ES91913139T patent/ES2094815T3/es not_active Expired - Lifetime
-
1997
- 1997-01-22 GR GR960403526T patent/GR3022337T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69123159T2 (de) | 1997-04-10 |
EP0610178A1 (en) | 1994-08-17 |
US5505966A (en) | 1996-04-09 |
JPH05508156A (ja) | 1993-11-18 |
DK0610178T3 (da) | 1997-04-14 |
SE9002339D0 (sv) | 1990-07-04 |
GR3022337T3 (en) | 1997-04-30 |
WO1992000732A1 (en) | 1992-01-23 |
ATE145132T1 (de) | 1996-11-15 |
EP0610178B1 (en) | 1996-11-13 |
AU8227291A (en) | 1992-02-04 |
DE69123159D1 (de) | 1996-12-19 |
SE9002339L (sv) | 1992-01-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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