ES2094342T3 - Nuevos complejos con contenido en acido nucleico, absorbibles, a traves de endocitosis, en celulas eucarioticas superiores. - Google Patents
Nuevos complejos con contenido en acido nucleico, absorbibles, a traves de endocitosis, en celulas eucarioticas superiores.Info
- Publication number
- ES2094342T3 ES2094342T3 ES92903641T ES92903641T ES2094342T3 ES 2094342 T3 ES2094342 T3 ES 2094342T3 ES 92903641 T ES92903641 T ES 92903641T ES 92903641 T ES92903641 T ES 92903641T ES 2094342 T3 ES2094342 T3 ES 2094342T3
- Authority
- ES
- Spain
- Prior art keywords
- nucleic acid
- complexes
- endocytosis
- eucarytic
- absorbable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
Abstract
COMPLEJOS ENTRE CONJUGADOS DE FACTORES DE UNION E INTERNALISACION Y ACIDO NUCLEINICO QUE PUEDEN ABSORBERSE EN GRAN NUMERO DE CELULAS EUCARIOTICAS POR ENDOCITOSIS CONTIENEN EN FORMA UNIDA NO COVALENTE UNA O VARIAS SUSTANCIAS AFINES DE ACIDO NUCLEINICO QUE PUEDEN ELEVAR LA EFICIENCIA DE LA ABSORCION DEL COMPLEJO EN LA CELULA. LA SUBSTANCIA AFIN DEL ACIDO NUCLEINO UNIDA NO COVALENTEMENTE ES IDENTICA AL FACTOR DE UNION O SUSTANCIA DE INTERNALISIACION ES PREFERENTES TRANSFERRICA. PROCEDIMIENTO PARA OBTENER EL COMPLEJO, Y UN PROCEDIMIENTO PARA INTRODUCIR ACIDO NUCLEICO EN GRAN NUMERO DE CELULAS EUCARIOTICAS. PREPARADO FARMACEUTICO QUE CONTIENE COMPLEJO CON UN ACIDO NUCLEINICO TERAPEUTICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4104186A DE4104186A1 (de) | 1991-02-12 | 1991-02-12 | Neue, ueber endozytose in hoehere eukaryotische zellen aufnehmbare, nukleinsaeure enthaltende komplexe |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2094342T3 true ES2094342T3 (es) | 1997-01-16 |
Family
ID=6424859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92903641T Expired - Lifetime ES2094342T3 (es) | 1991-02-12 | 1992-02-01 | Nuevos complejos con contenido en acido nucleico, absorbibles, a traves de endocitosis, en celulas eucarioticas superiores. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0571414B1 (es) |
JP (1) | JPH06504993A (es) |
AT (1) | ATE142890T1 (es) |
DE (2) | DE4104186A1 (es) |
ES (1) | ES2094342T3 (es) |
WO (1) | WO1992013570A2 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6022950A (en) * | 1984-06-07 | 2000-02-08 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
US5672683A (en) * | 1989-09-07 | 1997-09-30 | Alkermes, Inc. | Transferrin neuropharmaceutical agent fusion protein |
WO1993010819A1 (en) * | 1991-11-26 | 1993-06-10 | Alkermes, Inc. | Process for the preparation of transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates |
US5977307A (en) * | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
US5527527A (en) * | 1989-09-07 | 1996-06-18 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
US6057299A (en) * | 1994-01-13 | 2000-05-02 | Calydon, Inc. | Tissue-specific enhancer active in prostate |
US5830686A (en) * | 1994-01-13 | 1998-11-03 | Calydon | Tissue-specific enhancer active in prostate |
FR2719316B1 (fr) * | 1994-04-28 | 1996-05-31 | Idm | Nouveaux complexes d'acide nucléique et de polymère, leur procédé de préparation et leur utilisation pour la transfection de cellules. |
JPH0889278A (ja) * | 1994-09-29 | 1996-04-09 | Ajinomoto Co Inc | 遺伝子導入用修飾蛋白質及びその製法 |
US6015555A (en) * | 1995-05-19 | 2000-01-18 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates |
US6051429A (en) * | 1995-06-07 | 2000-04-18 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
EP0874910A4 (en) * | 1995-06-07 | 1999-04-21 | Life Technologies Inc | ENHANCED CATIONIC LIPID TRANSFECTION BY PEPTIDES |
FR2736642B1 (fr) * | 1995-07-10 | 1997-09-12 | Pasteur Institut | Immunovecteurs, notamment anticorps et fragments d'anticorps utilisables pour le transport intracellulaire et intranucleaire de principes biologiquement actifs notamment d'haptenes, de proteines et d'acides nucleiques |
FR2755976B1 (fr) * | 1996-11-15 | 1999-01-15 | Idm Immuno Designed Molecules | Nouveaux complexes d'acides nucleiques et de polymere substitue par des residus entrainant la destabilisation des membranes cellulaires |
DE69838584T2 (de) | 1997-08-04 | 2008-06-26 | Cell Genesys, Inc., Foster City | Enhancer des menschlichen glandulären kallikreingens, vektoren die ihn enthalten und methoden für seine verwendung |
US6927278B1 (en) * | 1998-09-01 | 2005-08-09 | Trustees Of The University Of Pennsylvania | Peptide scaffolds for transfer of molecules into eukaryotic cells |
EP2298728A1 (en) | 1998-11-12 | 2011-03-23 | Life Technologies Corporation | Transfection reagents |
US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
US6902933B2 (en) * | 2000-11-03 | 2005-06-07 | Regents Of The University Of Michigan | Surface transfection and expression procedure |
WO2004096117A2 (en) * | 2003-05-02 | 2004-11-11 | Xpression Antibody Therapeutics, Inc. | Drug delivery systems comprising transferrin-nucleic acid conjugates |
ATE469984T1 (de) | 2003-12-01 | 2010-06-15 | Life Technologies Corp | Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon |
EP2099496A2 (en) * | 2006-12-08 | 2009-09-16 | Massachusetts Institute of Technology | Delivery of nanoparticles and/or agents to cells |
MY173826A (en) | 2012-11-15 | 2020-02-24 | Roche Innovation Ct Copenhagen As | Oligonucleotide conjugates |
AU2015260725B2 (en) | 2014-05-14 | 2021-02-25 | Targimmune Therapeutics Ag | Improved polyethyleneimine polyethyleneglycol vectors |
US10195280B2 (en) | 2014-07-15 | 2019-02-05 | Life Technologies Corporation | Compositions and methods for efficient delivery of molecules to cells |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0387775T3 (da) * | 1989-03-16 | 1996-11-04 | Boehringer Ingelheim Int | Genetisk enhed til inhibering af funktionen af RNA |
US5354844A (en) * | 1989-03-16 | 1994-10-11 | Boehringer Ingelheim International Gmbh | Protein-polycation conjugates |
DE59106279D1 (de) * | 1990-05-18 | 1995-09-21 | Genentech Inc | Neue protein-polykation-konjugate. |
-
1991
- 1991-02-12 DE DE4104186A patent/DE4104186A1/de not_active Withdrawn
-
1992
- 1992-02-01 DE DE59207189T patent/DE59207189D1/de not_active Expired - Fee Related
- 1992-02-01 WO PCT/EP1992/000217 patent/WO1992013570A2/de active IP Right Grant
- 1992-02-01 EP EP92903641A patent/EP0571414B1/de not_active Expired - Lifetime
- 1992-02-01 AT AT92903641T patent/ATE142890T1/de not_active IP Right Cessation
- 1992-02-01 ES ES92903641T patent/ES2094342T3/es not_active Expired - Lifetime
- 1992-02-01 JP JP4503508A patent/JPH06504993A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE59207189D1 (de) | 1996-10-24 |
ATE142890T1 (de) | 1996-10-15 |
WO1992013570A2 (de) | 1992-08-20 |
EP0571414A1 (de) | 1993-12-01 |
EP0571414B1 (de) | 1996-09-18 |
WO1992013570A3 (de) | 1992-10-29 |
JPH06504993A (ja) | 1994-06-09 |
DE4104186A1 (de) | 1992-08-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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