ES2093765T3 - Derivados de 4-aril tiazoles o imidazoles. - Google Patents
Derivados de 4-aril tiazoles o imidazoles.Info
- Publication number
- ES2093765T3 ES2093765T3 ES92200825T ES92200825T ES2093765T3 ES 2093765 T3 ES2093765 T3 ES 2093765T3 ES 92200825 T ES92200825 T ES 92200825T ES 92200825 T ES92200825 T ES 92200825T ES 2093765 T3 ES2093765 T3 ES 2093765T3
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- hydrogen
- alk
- thiazole
- tiazoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Paints Or Removers (AREA)
- Polyurethanes Or Polyureas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
DERIVADOS DE 4-ARILO-TIAZOL O IMIDAZOL. LA INVENCION TRATA DE UN DERIVADO DE 4-ARILO-TIAZOL O IMIDAZOL CON LA FORMULA DONDE X ES O O NOH, Y ES S O NR3, AR ES UN GRUPO ELEGIDO ENTRE FENIL, NAFTIL, TETRAHIDRONAFTIL, Y BIFENILO, R ES DE UNO HASTA CUATRO SUPLENTES ESCOGIDOS INDEPENDIENTEMENTE ENTRE HIDROGENO, HIDROXI, ALQUILO INFERIOR, ALCOXI INFERIOR, TIOALQUILO INFERIOR, CICLOALQUINO, HALOGENO, CF3, NO2, Y O TICOS SATURADOS CON 2-6 ATOMOS DE CARBON, Y R1 Y R2 SON INDEPENDIENTEMENTE HIDROGENO O ALQUILO INFERIOR, O FORMAN, EN CONJUNTO CON EL ATOMO DE NITROGENO EL CUAL ESTA ENLAZADO, UN ANILLO HETEROCICLICO, Y R3 ES HIDROGENO O ALQUILO INFERIOR; O UNA SAL DE LO MISMO ACEPTABLE EN CUANTO A LA FARMACEUTICA, CON LA CONDICION DE QUE SE EXCLUYE 4 OXAMIDA. LOS COMPUESTOS SEGUN LA INVENCION AUMENTAN LA SENSIBILIDAD DE LAS MIOFIBRILLAS CARDIACAS AL CALCIO Y POSEEN ACTIVIDAD DE INHIBICION DE FOSFODIESTERASA Y ACTIVIDAD BRONCODILATOR, Y SON UTILES EN EL TRATAMIENTO DE PACIENTES QUIENES SUFREN INSUFICIENCIA CARDIACA Y ASMA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91302573 | 1991-03-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2093765T3 true ES2093765T3 (es) | 1997-01-01 |
Family
ID=8208225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92200825T Expired - Lifetime ES2093765T3 (es) | 1991-03-25 | 1992-03-23 | Derivados de 4-aril tiazoles o imidazoles. |
Country Status (17)
Country | Link |
---|---|
US (2) | US5254575A (es) |
EP (1) | EP0506194B1 (es) |
JP (1) | JPH0597816A (es) |
KR (1) | KR920018037A (es) |
AT (1) | ATE141597T1 (es) |
AU (1) | AU648394B2 (es) |
CA (1) | CA2063172A1 (es) |
DE (1) | DE69212870T2 (es) |
DK (1) | DK0506194T3 (es) |
ES (1) | ES2093765T3 (es) |
FI (1) | FI921262A (es) |
GR (1) | GR3021260T3 (es) |
IE (1) | IE73235B1 (es) |
MX (1) | MX9203810A (es) |
NO (1) | NO301929B1 (es) |
NZ (1) | NZ242095A (es) |
ZA (1) | ZA921781B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5922751A (en) * | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
USRE37234E1 (en) | 1996-11-01 | 2001-06-19 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses |
US5874437A (en) * | 1996-11-01 | 1999-02-23 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
US5958926A (en) * | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
WO1998019672A1 (en) * | 1996-11-01 | 1998-05-14 | Nitromed Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
AU6030098A (en) * | 1997-01-16 | 1998-08-07 | Neorx Corporation | Phalloidin derivatives and analogs to treat congestive heart failure |
US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
CA2381802C (en) | 1999-08-21 | 2010-12-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Synergistic combination of roflumilast and salmeterol |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
EA200501548A1 (ru) | 2003-04-01 | 2006-02-24 | Апплайд Резеч Системз Арс Холдинг Н.В. | Ингибиторы фосфодиэстераз при бесплодии |
US20070060584A1 (en) * | 2003-04-18 | 2007-03-15 | Chakravarty Prasun K | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers |
SA04250288B1 (ar) * | 2003-09-19 | 2008-07-19 | سولفاي فارماسوتيكالز بي . في | مشتقات ثيازول thiazole كمعدلات لمستقبل المكونات الكيميائية للقنب cannabinoid |
PE20070530A1 (es) * | 2005-10-26 | 2007-05-31 | Smithkline Beecham Corp | Compuestos derivados de tiazoles sustituidos como agentes de apertura de canales de potasio activados por calcio de alta conductancia |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EP2170930B3 (en) | 2007-06-04 | 2013-10-02 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
JP2011522828A (ja) | 2008-06-04 | 2011-08-04 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
DK2681236T3 (en) | 2011-03-01 | 2018-04-16 | Synergy Pharmaceuticals Inc | PROCEDURE FOR MANUFACTURING GUANYLATE CYCLASE-C-AGONISTS |
EP2958577A2 (en) | 2013-02-25 | 2015-12-30 | Synergy Pharmaceuticals Inc. | Guanylate cyclase receptor agonists for use in colonic cleansing |
WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
EP3004138B1 (en) | 2013-06-05 | 2024-03-13 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
AU2014305843B2 (en) | 2013-08-09 | 2019-08-29 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
US20200368223A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Methods for inhibiting phosphate transport |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU168036B (es) * | 1973-11-09 | 1976-02-28 | ||
FR2261756A1 (en) * | 1974-02-27 | 1975-09-19 | Roussel Uclaf | 2-Thiazole-N-(Piperazino or piperidino) alkyl carboxamides - as hypotensive and anti-hypertensive agents of low toxicity |
DE3669160D1 (en) * | 1985-03-27 | 1990-04-05 | Zenyaku Kogyo Kk | Thiazolderivate. |
JPH02262562A (ja) * | 1988-10-20 | 1990-10-25 | Ishihara Sangyo Kaisha Ltd | イミダゾール系化合物 |
-
1992
- 1992-03-06 IE IE920734A patent/IE73235B1/en not_active IP Right Cessation
- 1992-03-10 ZA ZA921781A patent/ZA921781B/xx unknown
- 1992-03-13 AU AU12915/92A patent/AU648394B2/en not_active Ceased
- 1992-03-17 CA CA002063172A patent/CA2063172A1/en not_active Abandoned
- 1992-03-23 EP EP92200825A patent/EP0506194B1/en not_active Expired - Lifetime
- 1992-03-23 NZ NZ242095A patent/NZ242095A/en unknown
- 1992-03-23 AT AT92200825T patent/ATE141597T1/de not_active IP Right Cessation
- 1992-03-23 DK DK92200825.5T patent/DK0506194T3/da active
- 1992-03-23 KR KR1019920004745A patent/KR920018037A/ko not_active Application Discontinuation
- 1992-03-23 DE DE69212870T patent/DE69212870T2/de not_active Expired - Fee Related
- 1992-03-23 ES ES92200825T patent/ES2093765T3/es not_active Expired - Lifetime
- 1992-03-24 FI FI921262A patent/FI921262A/fi not_active Application Discontinuation
- 1992-03-24 NO NO921156A patent/NO301929B1/no unknown
- 1992-03-25 JP JP4067491A patent/JPH0597816A/ja active Pending
- 1992-03-25 US US07/857,526 patent/US5254575A/en not_active Expired - Fee Related
- 1992-06-29 MX MX9203810A patent/MX9203810A/es unknown
-
1993
- 1993-10-14 US US08/136,530 patent/US5462959A/en not_active Expired - Fee Related
-
1996
- 1996-10-04 GR GR960402611T patent/GR3021260T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH0597816A (ja) | 1993-04-20 |
NO921156D0 (no) | 1992-03-24 |
DK0506194T3 (da) | 1996-12-23 |
CA2063172A1 (en) | 1992-09-26 |
NO921156L (no) | 1992-09-28 |
NO301929B1 (no) | 1997-12-29 |
US5254575A (en) | 1993-10-19 |
MX9203810A (es) | 1992-07-31 |
DE69212870D1 (de) | 1996-09-26 |
EP0506194A1 (en) | 1992-09-30 |
US5462959A (en) | 1995-10-31 |
EP0506194B1 (en) | 1996-08-21 |
ATE141597T1 (de) | 1996-09-15 |
KR920018037A (ko) | 1992-10-21 |
FI921262A0 (fi) | 1992-03-24 |
IE920734A1 (en) | 1992-10-07 |
DE69212870T2 (de) | 1997-01-16 |
AU648394B2 (en) | 1994-04-21 |
FI921262A (fi) | 1992-09-26 |
ZA921781B (en) | 1992-11-25 |
GR3021260T3 (en) | 1997-01-31 |
AU1291592A (en) | 1992-10-01 |
IE73235B1 (en) | 1997-05-21 |
NZ242095A (en) | 1994-04-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2093765T3 (es) | Derivados de 4-aril tiazoles o imidazoles. | |
RU2403251C2 (ru) | Производные 2, 4-ди(гетеро)ариламинопиримидина в качестве ингибиторов zap-70 | |
NO20004485L (no) | Sykloalkenderivater, deres fremstilling og anvendelse | |
DE69109631D1 (de) | 2-Substituierte Adenosinderivate und pharmazeutische Zusammensetzungen zur Verwendung gegen Infektionskrankheiten. | |
NO170084C (no) | Analogifremgangsmaate til fremstilling av terapeutisk aktive dihydropyridinderivater | |
ATE123771T1 (de) | Stickstoff enthaltende heterozyklische verbindungen, ihre herstellung und verwendung. | |
HUP0500455A2 (hu) | Parciális és teljes A1-agonisták N6-heterociklusos-5'-tiocsoporttal szubsztituált adenozinszármazékok | |
ATE244240T1 (de) | Kondensierte heterocyclische verbindungen, ihre herstellung und verwendung | |
DE3781080T2 (de) | 2-substituierte-e-kondensierte(1,2,4)triazolo-(1,5-c)pyrimidine, pharmazeutische zubereitungen und ihre verwendung. | |
ATE353870T1 (de) | Dibenzylaminverbindung und deren medizinische verwendung | |
DE69412534T2 (de) | Piperazin-Derivate und ihre Verwendung als Calmodulin-Inhibitoren | |
EP0168262A3 (en) | Pyrimidine derivatives, processes for preparation thereof and use thereof | |
DE68920654T2 (de) | 4-Oxochinolin-3-carbonsäure-Derivate, ihre Herstellung und ihre Verwendung. | |
NO924522L (no) | Optisk aktive azolforbindelser, deres fremstilling og anvendelse | |
RU2006128788A (ru) | Производные фенил[4-(3-фенил-1н-пиразол-4-ил)пиримидин-2-ил] амина в качестве igf-1r ингибиторов | |
WO2004004730A3 (en) | 2-aminopyrazine derivatives as inhibitors of cyclin dependent kinases for the treatment of proliferative disorders | |
DK0565377T3 (da) | Terapeutiske midler til behandling af Parkinsons sygdom | |
DK275483D0 (da) | 1,2,4-triazolderivater eller deres farmaceutisk acceptable salte, fremgangsmade til fremstilling deraf og landbrugsfungicider indeholdende disse forbindelser | |
DK224981A (da) | Aminopropanol-derivater og deres syreadditionssalte fremgangsmaader til deres fremstilling og deres anvendelse som fungicider | |
DE69406763D1 (de) | Pyridazinon Derivate, Herstellungsverfahren und Verwendung | |
FR2629456B1 (fr) | Derives des acides 7-(1-imidazolyl),1,4-dihydro-4-oxo-6,8-difluoro-1-cyclopropyl-3-quinoleincarboxylique, leur preparation et leur application en tant que medicaments |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 506194 Country of ref document: ES |