ES2093130T3 - Forma de ciclosporin para administracion pulmonar. - Google Patents

Forma de ciclosporin para administracion pulmonar.

Info

Publication number
ES2093130T3
ES2093130T3 ES92104426T ES92104426T ES2093130T3 ES 2093130 T3 ES2093130 T3 ES 2093130T3 ES 92104426 T ES92104426 T ES 92104426T ES 92104426 T ES92104426 T ES 92104426T ES 2093130 T3 ES2093130 T3 ES 2093130T3
Authority
ES
Spain
Prior art keywords
cyclosporin
lung administration
well
crystalline
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92104426T
Other languages
English (en)
Spanish (es)
Inventor
John Morley
Andreas Rummelt
Martin List
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Application granted granted Critical
Publication of ES2093130T3 publication Critical patent/ES2093130T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • C07K7/645Cyclosporins; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES92104426T 1991-03-18 1992-03-14 Forma de ciclosporin para administracion pulmonar. Expired - Lifetime ES2093130T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919105705A GB9105705D0 (en) 1991-03-18 1991-03-18 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
ES2093130T3 true ES2093130T3 (es) 1996-12-16

Family

ID=10691762

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92104426T Expired - Lifetime ES2093130T3 (es) 1991-03-18 1992-03-14 Forma de ciclosporin para administracion pulmonar.

Country Status (29)

Country Link
US (1) US5719123A (US08197722-20120612-C00042.png)
EP (1) EP0504760B1 (US08197722-20120612-C00042.png)
JP (1) JP2549794B2 (US08197722-20120612-C00042.png)
KR (1) KR920017644A (US08197722-20120612-C00042.png)
AT (1) AT404553B (US08197722-20120612-C00042.png)
AU (1) AU658172B2 (US08197722-20120612-C00042.png)
CA (1) CA2063106C (US08197722-20120612-C00042.png)
CH (1) CH685229A5 (US08197722-20120612-C00042.png)
CZ (1) CZ281260B6 (US08197722-20120612-C00042.png)
DE (1) DE4208258B4 (US08197722-20120612-C00042.png)
DK (1) DK0504760T3 (US08197722-20120612-C00042.png)
ES (1) ES2093130T3 (US08197722-20120612-C00042.png)
FI (1) FI921125A (US08197722-20120612-C00042.png)
FR (1) FR2674249A1 (US08197722-20120612-C00042.png)
GB (2) GB9105705D0 (US08197722-20120612-C00042.png)
GR (1) GR3021497T3 (US08197722-20120612-C00042.png)
HU (1) HU208492B (US08197722-20120612-C00042.png)
IE (1) IE67627B1 (US08197722-20120612-C00042.png)
IL (1) IL101244A (US08197722-20120612-C00042.png)
IT (1) IT1255040B (US08197722-20120612-C00042.png)
LU (1) LU88087A1 (US08197722-20120612-C00042.png)
MX (1) MX9201141A (US08197722-20120612-C00042.png)
NO (1) NO310754B1 (US08197722-20120612-C00042.png)
NZ (1) NZ241975A (US08197722-20120612-C00042.png)
RU (1) RU2098122C1 (US08197722-20120612-C00042.png)
SA (1) SA92120536B1 (US08197722-20120612-C00042.png)
SK (1) SK279576B6 (US08197722-20120612-C00042.png)
TW (1) TW215901B (US08197722-20120612-C00042.png)
ZA (1) ZA921987B (US08197722-20120612-C00042.png)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5837677B2 (ja) * 1981-01-13 1983-08-17 松下電器産業株式会社 誘導加熱調理器
JPH07111905B2 (ja) * 1987-07-23 1995-11-29 株式会社東芝 誘導加熱調理器の負荷適否検知回路
KR100277622B1 (ko) * 1992-06-12 2001-01-15 이타가키 히로시 흡입용 초미립자 분말 및 그의 제조방법
US5512269A (en) * 1993-06-09 1996-04-30 Burroughs Wellcome, Co. Method of treating retained pulmonary secretions
PE44995A1 (es) * 1994-01-27 1995-12-18 Schering Corp Furoato de mometasona para el tratamiento de las enfermedades pulmonares y de las vias respiratorias
AU3453897A (en) * 1996-07-08 1998-02-02 Rhone-Poulenc Rorer Limited Medicinal cyclosporin-a aerosol solution formulation
US6517860B1 (en) 1996-12-31 2003-02-11 Quadrant Holdings Cambridge, Ltd. Methods and compositions for improved bioavailability of bioactive agents for mucosal delivery
US5898028A (en) * 1997-03-20 1999-04-27 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
TW581681B (en) * 1998-02-20 2004-04-01 Nektar Therapeutics Liquid crystal forms of cyclosporin
US20020006901A1 (en) * 1999-02-05 2002-01-17 Aldo T. Iacono Use of aerosolized cyclosporine for prevention and treatment of pulmonary disease
FI20002217A (fi) * 1999-12-30 2001-07-01 Orion Yhtymae Oyj Inhalaatiopartikkelit
FI20010115A0 (fi) * 2001-01-18 2001-01-18 Orion Corp Menetelmä nanopartikkelien valmistamiseksi
KR100978836B1 (ko) * 2001-10-19 2010-08-30 이소테크니카 인코포레이티드 신규한 시클로스포린 유사체 미세유화액 예비농축물
WO2004069223A2 (en) * 2003-02-06 2004-08-19 Cipla Ltd Pharmaceutical compositions comprising immunosuppressants and uses thereof
DK1610878T3 (da) * 2003-02-21 2014-12-01 Univ Bath Fremgangsmåde til fremstilling af partikler
US20050059583A1 (en) * 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
EP1781257B1 (en) * 2004-08-13 2018-12-19 Emisphere Technologies, Inc. Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
US7151085B2 (en) 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
US20080114577A1 (en) * 2005-11-30 2008-05-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational methods and systems associated with nutraceutical related assays
US20110145009A1 (en) * 2005-11-30 2011-06-16 Jung Edward K Y Methods and systems related to transmission of nutraceutical associatd information
US8297028B2 (en) 2006-06-14 2012-10-30 The Invention Science Fund I, Llc Individualized pharmaceutical selection and packaging
US7927787B2 (en) * 2006-06-28 2011-04-19 The Invention Science Fund I, Llc Methods and systems for analysis of nutraceutical associated components
US20070124219A1 (en) * 2005-11-30 2007-05-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational and/or control systems related to individualized nutraceutical selection and packaging
US20070124176A1 (en) * 2005-11-30 2007-05-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational and/or control systems and methods related to nutraceutical agent selection and dosing
US7974856B2 (en) 2005-11-30 2011-07-05 The Invention Science Fund I, Llc Computational systems and methods related to nutraceuticals
US8340944B2 (en) * 2005-11-30 2012-12-25 The Invention Science Fund I, Llc Computational and/or control systems and methods related to nutraceutical agent selection and dosing
US20070136092A1 (en) * 2005-11-30 2007-06-14 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational and/or control systems related to individualized pharmaceutical and nutraceutical selection and packaging
US8068991B2 (en) * 2005-11-30 2011-11-29 The Invention Science Fund I, Llc Systems and methods for transmitting pathogen related information and responding
US8000981B2 (en) 2005-11-30 2011-08-16 The Invention Science Fund I, Llc Methods and systems related to receiving nutraceutical associated information
US20080004905A1 (en) * 2006-06-28 2008-01-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for analysis of nutraceutical associated components
US20070289258A1 (en) * 2006-06-14 2007-12-20 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Individualized pharmaceutical selection and packaging
US7827042B2 (en) * 2005-11-30 2010-11-02 The Invention Science Fund I, Inc Methods and systems related to transmission of nutraceutical associated information
US10296720B2 (en) * 2005-11-30 2019-05-21 Gearbox Llc Computational systems and methods related to nutraceuticals
US20070174128A1 (en) * 2005-11-30 2007-07-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational and/or control systems related to individualized pharmaceutical and nutraceutical selection and packaging
US20080033763A1 (en) * 2005-11-30 2008-02-07 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems related to receiving nutraceutical associated information
US20080052114A1 (en) * 2005-11-30 2008-02-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational systems and methods related to nutraceuticals
DE102006051512A1 (de) 2005-12-06 2007-06-14 Pari GmbH Spezialisten für effektive Inhalation Pharmazeutische Medikamentenzusammensetzungen mit Cyclosporin
US20070219127A1 (en) * 2006-03-20 2007-09-20 Walt John G Cyclosporin a compositions
UA113627C2 (xx) * 2011-05-27 2017-02-27 Кристалічна форма циклоспорину a, фармацевтична композиція та спосіб лікування
JO3410B1 (ar) 2011-06-07 2019-10-20 Otsuka Pharma Co Ltd تركيبة أريبيبرازول مجفف بالتبريد
BR112014011768A2 (pt) * 2011-11-15 2017-05-09 Allergan Inc forma 2 de ciclosporina a e método de produção da mesma

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU203564B (en) * 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
CH679119A5 (US08197722-20120612-C00042.png) * 1988-05-13 1991-12-31 Sandoz Ag
GB8916901D0 (en) * 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds

Also Published As

Publication number Publication date
KR920017644A (ko) 1992-10-21
ATA53492A (de) 1998-05-15
IT1255040B (it) 1995-10-13
FI921125A (fi) 1992-09-19
NO921012L (no) 1992-09-21
ITRM920181A1 (it) 1993-09-17
EP0504760B1 (en) 1996-10-09
AU658172B2 (en) 1995-04-06
ITRM920181A0 (it) 1992-03-17
GR3021497T3 (en) 1997-01-31
TW215901B (US08197722-20120612-C00042.png) 1993-11-11
LU88087A1 (fr) 1993-10-27
HUT61324A (en) 1992-12-28
IE920839A1 (en) 1992-09-23
GB9205554D0 (en) 1992-04-29
DE4208258A1 (de) 1992-09-24
CS78592A3 (en) 1992-10-14
US5719123A (en) 1998-02-17
SA92120536B1 (ar) 2005-04-27
JPH0585940A (ja) 1993-04-06
CA2063106A1 (en) 1992-09-19
CH685229A5 (de) 1995-05-15
NZ241975A (en) 1994-04-27
SK279576B6 (sk) 1999-01-11
ZA921987B (en) 1993-09-20
HU9200735D0 (en) 1992-05-28
IL101244A (en) 1996-10-31
DE4208258B4 (de) 2007-07-12
GB2253853A (en) 1992-09-23
JP2549794B2 (ja) 1996-10-30
FR2674249A1 (fr) 1992-09-25
FI921125A0 (fi) 1992-03-16
RU2098122C1 (ru) 1997-12-10
HU208492B (en) 1993-11-29
CA2063106C (en) 2002-12-17
DK0504760T3 (da) 1996-12-23
AU1294092A (en) 1992-09-24
AT404553B (de) 1998-12-28
GB9105705D0 (en) 1991-05-01
MX9201141A (es) 1992-10-01
GB2253853B (en) 1995-04-26
NO310754B1 (no) 2001-08-27
NO921012D0 (no) 1992-03-16
EP0504760A1 (en) 1992-09-23
CZ281260B6 (cs) 1996-07-17
FR2674249B1 (US08197722-20120612-C00042.png) 1995-05-12
IL101244A0 (en) 1992-11-15
IE67627B1 (en) 1996-04-17

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