ES2088416T3 - Ensayo para el cribado de farmacos. - Google Patents

Ensayo para el cribado de farmacos.

Info

Publication number
ES2088416T3
ES2088416T3 ES90308891T ES90308891T ES2088416T3 ES 2088416 T3 ES2088416 T3 ES 2088416T3 ES 90308891 T ES90308891 T ES 90308891T ES 90308891 T ES90308891 T ES 90308891T ES 2088416 T3 ES2088416 T3 ES 2088416T3
Authority
ES
Spain
Prior art keywords
union
sample compound
trial
galactosidase
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90308891T
Other languages
English (en)
Inventor
Pyare Khanna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microgenics Corp
Original Assignee
Microgenics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microgenics Corp filed Critical Microgenics Corp
Application granted granted Critical
Publication of ES2088416T3 publication Critical patent/ES2088416T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

SE CALCULAN COMPUESTOS PARA SU UNION A RECEPTORES NATURALMENTE INCIDENTALES, EMPLEANDO EL LIGANDO NATURAL CONJUGADO A UN FRAGMENTO DONANTE DE ENZIMAS DE (BETA)-GALACTOSIDASA PARA COMPETIR CON EL COMPUESTO DE MUESTRA PARA EL LUGAR DE UNION DEL ACEPTOR NATURAL, O EN AUSENCIA DE COMPETICION DONDE EL COMPUESTO DE MUESTRA SE UNE A UN LUGAR ALLOSTERICO. MEDIANTE LA ADICION DEL FRAGMENTO ACEPTOR DE ENZIMAS DE LA (BETA)-GALACTOSIDASA Y SUBSTRATO, LA AFINIDAD DE UNION DEL COMPUESTO DE MUESTRA PUEDE CALCULARSE COMO UNA MEDIDA DE CAPACIDAD COMBATIENTE O ANTAGONISTA.
ES90308891T 1989-08-15 1990-08-13 Ensayo para el cribado de farmacos. Expired - Lifetime ES2088416T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39401789A 1989-08-15 1989-08-15

Publications (1)

Publication Number Publication Date
ES2088416T3 true ES2088416T3 (es) 1996-08-16

Family

ID=23557200

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90308891T Expired - Lifetime ES2088416T3 (es) 1989-08-15 1990-08-13 Ensayo para el cribado de farmacos.

Country Status (7)

Country Link
US (1) US5434052A (es)
EP (1) EP0421589B1 (es)
JP (1) JP2846433B2 (es)
AU (1) AU649958B2 (es)
CA (1) CA1335707C (es)
DE (1) DE69026328T2 (es)
ES (1) ES2088416T3 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19503320A1 (de) * 1995-02-02 1996-08-08 Boehringer Mannheim Gmbh Neue Benzodiazepinkonjugate
US5976857A (en) * 1996-01-26 1999-11-02 Boehringer Mannheim Corporation Cross-linked polypeptide fragments of β-galactosidase
US5763196A (en) * 1996-01-26 1998-06-09 Boehringer Mannheim Corporation Assays using cross-linked polypeptide fragments of β-galactosidase
ATE211480T1 (de) * 1996-01-26 2002-01-15 Roche Diagnostics Corp Bismaleinsäureimid-vernetzer
US6342345B1 (en) * 1997-04-02 2002-01-29 The Board Of Trustees Of The Leland Stanford Junior University Detection of molecular interactions by reporter subunit complementation
US6673554B1 (en) * 1999-06-14 2004-01-06 Trellie Bioinformatics, Inc. Protein localization assays for toxicity and antidotes thereto
DE10028204A1 (de) * 2000-06-09 2002-01-03 Aventis Pharma Gmbh Verfahren zur Auffindung von medizinisch wertvollen Wirkstoffen
ATE399212T1 (de) * 2002-01-29 2008-07-15 Discoverx Inc Enzymaktivierungsprotease-assay
US20030228621A1 (en) * 2002-05-24 2003-12-11 Yong Qin Common ligand universal enzyme assay and compositions for use therein
US7452690B2 (en) * 2003-01-28 2008-11-18 Discoverx Corporation Protease EFC cell surface fusion protein assay
US8945853B2 (en) * 2012-02-06 2015-02-03 Discoverx Corporation Detection of intracellular binding events by measuring protein abundance

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US4134792A (en) * 1976-12-06 1979-01-16 Miles Laboratories, Inc. Specific binding assay with an enzyme modulator as a labeling substance
US4375459A (en) * 1980-06-20 1983-03-01 The Regents Of The University Of California Cytoreceptor assay
DE3262956D1 (en) * 1981-06-22 1985-05-15 Technicon Instr Labelled vitamin b12 derivatives, their preparation and use
US4399228A (en) * 1981-07-30 1983-08-16 Corning Glass Works Polate competitive protein binding assay
US4708929A (en) * 1984-10-29 1987-11-24 Microgenics Corporation Methods for protein binding enzyme complementation assays
WO1986002666A1 (en) * 1984-10-29 1986-05-09 Microgenics Corporation Methods for protein binding enzyme complementation assays
US4760029A (en) * 1984-11-19 1988-07-26 Schering Corporation Assay for D-1 antagonistic activity of neuroleptic drugs
DE3546014A1 (de) * 1985-12-24 1987-06-25 Boehringer Mannheim Gmbh Verfahren zur bestimmung der bindungskapazitaet des thyroxin bindenden tbg
US4859585A (en) * 1986-04-17 1989-08-22 Trustees Of Tufts College In-vitro methods for identifying compositions which are agonists and antagonists of estrogens
US4997771A (en) * 1987-04-27 1991-03-05 Schering Corporation Method for measuring the BZ-1 receptor binding activity in a test sample or test compound
IL85597A (en) * 1987-05-18 1992-08-18 Technicon Instr Immunoassay method and composition using conjugate of analyte and reaction intermediate for analyte capable of mediating signal generation
US4950591A (en) * 1987-08-14 1990-08-21 Cherksey Bruce D Membrane Na+ channel protein and related therapeutic compounds
AU610281B2 (en) * 1987-09-21 1991-05-16 Roche Diagnostics Corporation Solid-phase non-separation enzyme assay
DE3889407T2 (de) * 1987-10-02 1994-11-03 Microgenics Corp Homogenes Verfahren zur Bestimmung der T-3- oder T-4-Aufnahme und Zusammensetzung dafür.
ATE104058T1 (de) * 1988-02-02 1994-04-15 Microgenics Corp Rezeptorpreincubations-enzymtest.
ES2093026T3 (es) * 1989-05-05 1996-12-16 Microgenics Corp Procedimiento de ensayo de complementacion enzimatico de enlace e proteinas.
US5328830A (en) * 1992-09-08 1994-07-12 Miles Inc. Potassium channel modulators

Also Published As

Publication number Publication date
EP0421589A3 (en) 1991-12-18
JPH03175360A (ja) 1991-07-30
EP0421589A2 (en) 1991-04-10
DE69026328D1 (de) 1996-05-09
AU6099390A (en) 1991-02-21
JP2846433B2 (ja) 1999-01-13
DE69026328T2 (de) 1996-10-02
AU649958B2 (en) 1994-06-09
CA1335707C (en) 1995-05-30
EP0421589B1 (en) 1996-04-03
US5434052A (en) 1995-07-18

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