ES2087383T3 - Procedimiento para la produccion de hidroxocobalamina. - Google Patents

Procedimiento para la produccion de hidroxocobalamina.

Info

Publication number
ES2087383T3
ES2087383T3 ES92115778T ES92115778T ES2087383T3 ES 2087383 T3 ES2087383 T3 ES 2087383T3 ES 92115778 T ES92115778 T ES 92115778T ES 92115778 T ES92115778 T ES 92115778T ES 2087383 T3 ES2087383 T3 ES 2087383T3
Authority
ES
Spain
Prior art keywords
vitamin
type
resin
hydroxycobalamine
solution containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92115778T
Other languages
English (en)
Inventor
Takayuki Hirayama
Takashi Kiyota
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eneos Corp
Original Assignee
Nippon Oil Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Oil Corp filed Critical Nippon Oil Corp
Application granted granted Critical
Publication of ES2087383T3 publication Critical patent/ES2087383T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

UN PROCESO PARA LA PRODUCCION DE HIDROXICOBALAMINA COMPRENDE LOS PASOS DE: (1) PONER UNA SOLUCION QUE CONTIENE VITAMINA B12 DEL TIPO COENZIMA EN CONTACTO CON UNA RESINA DE COPOLIMERO DE DIVINILBENCENO/ESTIRENO DE MANERA QUE LA VITAMINA B12 DEL TIPO CO-ENZIMA SEA ABSORBIDA EN LA RESINA; (2) LAVAR LA RESINA CON AGUA PURIFICADA O SOLUCION LIMPIADORA ACUOSA A UNA TEMPERATURA ENTRE 30 (GRADOS) C Y 70 (GRADOS) C PARA ELIMINAR IMPUREZAS; (3) EXTRAER LA VITAMINA B12 DEL TIPO CO-ENZIMA ABSORBIDA EN LA RESINA CON UNA SOLUCION ACUOSA QUE CONTIENE AL MENOS 25% DE UN ALCOHOL BAJO, PARA OBTENER UN ELUIDO QUE CONTENGA VITAMINA B12 DEL TIPO CO-ENZIMA; (4) IRRADIAR EL ELUIDO CON UNA LUZ PARA CONVERTIR LA VITAMINA B12 DEL TIPO CO-ENZIMA PARA HIDROXICOBALAMINA; Y (5) TRATAR LA SOLUCION QUE CONTIENE HIDROXICOBALAMINA DEL PASO (4) CON UN ABSORBENTE INORGANICO Y RECUPERAR LA HIDROXICOBALAMINA.
ES92115778T 1991-09-17 1992-09-16 Procedimiento para la produccion de hidroxocobalamina. Expired - Lifetime ES2087383T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP03236486A JP3085320B2 (ja) 1991-09-17 1991-09-17 ヒドロキソコバラミンの製造方法

Publications (1)

Publication Number Publication Date
ES2087383T3 true ES2087383T3 (es) 1996-07-16

Family

ID=17001447

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92115778T Expired - Lifetime ES2087383T3 (es) 1991-09-17 1992-09-16 Procedimiento para la produccion de hidroxocobalamina.

Country Status (5)

Country Link
US (1) US5338418A (es)
EP (1) EP0533115B1 (es)
JP (1) JP3085320B2 (es)
DE (1) DE69210925T2 (es)
ES (1) ES2087383T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022986A1 (es) * 1996-08-12 2002-09-04 Gist Brocades Bv Produccion y uso de composiciones que comprenden concentraciones altas de actividad de vitamina b12
CN102351933B (zh) * 2011-07-25 2014-04-02 河北玉星生物工程有限公司 一种制备羟钴胺盐的方法
CN102516340A (zh) * 2011-11-14 2012-06-27 天津理工大学 一种采用d150大孔树脂分离纯化羟钴胺素的方法
CN102977173A (zh) * 2012-12-13 2013-03-20 上海华震科技有限公司 一种高纯度维生素b12的纯化工艺
US11324771B2 (en) 2020-02-12 2022-05-10 RK Pharma Solutions LLC Process for the preparation of hydroxocobalamin hydrochloride

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA689028A (en) * 1964-06-23 Boige Jean Hydroxocobalamin purification process
US2695862A (en) * 1949-08-04 1954-11-30 Merck & Co Inc Process for obtaining vitamin b12
US2668137A (en) * 1949-12-13 1954-02-02 Merck & Co Inc Vitamin b12 elution from charcoal
US2626888A (en) * 1950-09-07 1953-01-27 Merck & Co Inc Vitamin b12-active substance elution from monmorillonite absorbents
US2694679A (en) * 1951-03-27 1954-11-16 Merck & Co Inc Preparing vitamin b12 analogs
US2830009A (en) * 1955-03-01 1958-04-08 American Cyanamid Co Chromatographic recovery of vitamin b12
GB1012360A (en) * 1961-09-07 1965-12-08 Pierrel Spa A process for the preparation of hydroxycobalamin from cyanocobalamin
FR1330307A (fr) * 1962-05-11 1963-06-21 Procédé d'extraction de l'hydroxocobalamine
FR1325304A (fr) * 1962-06-04 1963-04-26 Pierrel Spa Procédé de fabrication d'hydroxycobalamine à partir de matières premières naturelles
FR1518600A (fr) * 1966-03-07 1968-03-29 Procédé pour la fabrication industrielle de l'hydroxocobalamine
MC1058A1 (fr) * 1975-04-29 1976-02-20 Ngoc D Bui Procede de preparation d'hydroxocobalamine et de ses sels
US4383110A (en) * 1980-11-29 1983-05-10 Nippon Oil Company, Ltd. Process for purifying and separating vitamin B12
EP0109859A3 (en) * 1982-11-22 1985-09-11 Nippon Oil Co. Ltd. Process for purifying and separating vatimin b12

Also Published As

Publication number Publication date
DE69210925D1 (de) 1996-06-27
EP0533115B1 (en) 1996-05-22
US5338418A (en) 1994-08-16
DE69210925T2 (de) 1996-10-31
JPH0586089A (ja) 1993-04-06
EP0533115A1 (en) 1993-03-24
JP3085320B2 (ja) 2000-09-04

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