ES2087019A1 - Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa. - Google Patents

Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.

Info

Publication number
ES2087019A1
ES2087019A1 ES09400217A ES9400217A ES2087019A1 ES 2087019 A1 ES2087019 A1 ES 2087019A1 ES 09400217 A ES09400217 A ES 09400217A ES 9400217 A ES9400217 A ES 9400217A ES 2087019 A1 ES2087019 A1 ES 2087019A1
Authority
ES
Spain
Prior art keywords
alkyl
acyl
bisubstituted
phenols
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09400217A
Other languages
English (en)
Other versions
ES2087019B1 (es
Inventor
De Falgas Joaquin Bonal
Belmonte Lorenzo Lopez
Navarro Luis Vila
Pujol Antonio Maria Molins
Novales Luis Lacoma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bobel246 S L
Original Assignee
Bobel246 S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES09400217A priority Critical patent/ES2087019B1/es
Application filed by Bobel246 S L filed Critical Bobel246 S L
Priority to PCT/ES1995/000017 priority patent/WO1995021610A1/es
Priority to JP7520985A priority patent/JPH08511561A/ja
Priority to AU16662/95A priority patent/AU706305B2/en
Priority to CA002160161A priority patent/CA2160161C/en
Priority to NZ279509A priority patent/NZ279509A/en
Priority to MX9504248A priority patent/MX9504248A/es
Priority to BR9505842A priority patent/BR9505842A/pt
Priority to EP95908286A priority patent/EP0707849B1/en
Priority to ES95908286T priority patent/ES2171532T3/es
Priority to AT95908286T priority patent/ATE210974T1/de
Priority to DE69524709T priority patent/DE69524709T2/de
Publication of ES2087019A1 publication Critical patent/ES2087019A1/es
Application granted granted Critical
Publication of ES2087019B1 publication Critical patent/ES2087019B1/es
Priority to US08/997,635 priority patent/US5985937A/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/367—Halogenated derivatives polycyclic non-condensed, containing only six-membered aromatic rings as cyclic parts, e.g. halogenated poly-hydroxyphenylalkanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/055—Phenols the aromatic ring being substituted by halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/06—Phenols the aromatic ring being substituted by nitro groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/26—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/26—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms
    • C07C39/27—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms all halogen atoms being bound to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

USO DE DERIVADOS DE FENOLES 2,4-DISUBSTITUIDOS COMO INHIBIDORES DE LA 5-LIPOXIGENASA. LOS PRODUCTOS DE FORMULA (I) DONDE: R2 ES (C1-C4)-ALQUILO, (C1-C4)-ACILO, CF3 CL, BR O I; R3 ES H, (C1-C4)-ALQUILO, (C1-C4)-ACILO, (C1-C4)-ALCOXILO, CF3, F, CL, BR, FENILO, OH, SH, NH2 O AMINO MONO- O DISUBSTITUIDO POR (C1-C3)-ALQUILO; R4 ES (C1-C4)-ALQUILO, (C1-C4)-ACILO, CF3, F, CL, BR, I, CARBOXILO, (C1-C4)-ALCOXICARBONILO, CIANO, NITRO O FENILO; Y R6 ES H, (C1-C4)-ALQUILO, (C1-C4)-ACILO, CF3, CL, BR O I, PRESENTAN, JUNTO A UNA TOXICIDAD BAJA, UNA ACTIVIDAD INHIBIDORA DE LA 5-LIPOXIGENASA MUCHO MAYOR QUE LA DEL BENAPROFENO O DEL KETOCONAZOL. ESTO LES HACE MUY VENTAJOSOS PARA LA PREPARACION DE MEDICAMENTOS CONTRA ENFERMEDADES MEDIADAS POR LEUCOTRIENOS, TALES COMO ARTRITIS REUMATOIDE, COLITIS ULCEROSA, ASMA, PSORIASIS Y HERPES.
ES09400217A 1994-02-08 1994-02-08 Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa. Expired - Fee Related ES2087019B1 (es)

Priority Applications (13)

Application Number Priority Date Filing Date Title
ES09400217A ES2087019B1 (es) 1994-02-08 1994-02-08 Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.
AT95908286T ATE210974T1 (de) 1994-02-08 1995-02-06 Verwendung von derivaten von 2,4-disubstituierten phenolen als 5-lipoxygenaseinhibitoren
AU16662/95A AU706305B2 (en) 1994-02-08 1995-02-06 Use of 2,4-bisubstituted phenol derivatives as 5-lipoxigenase inhibitors
CA002160161A CA2160161C (en) 1994-02-08 1995-02-06 Use of derivatives of 2,4-bisubstituted phenols as 5-lipoxigenase inhibitors
NZ279509A NZ279509A (en) 1994-02-08 1995-02-06 Use of 2,4-bisubstituted phenols as 5-lipoxigenase inhibitors
MX9504248A MX9504248A (es) 1994-02-08 1995-02-06 Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.
PCT/ES1995/000017 WO1995021610A1 (es) 1994-02-08 1995-02-06 Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa
EP95908286A EP0707849B1 (en) 1994-02-08 1995-02-06 Use of derivatives of 2,4-disubstituted phenols as 5-lipoxigenase inhibitors
ES95908286T ES2171532T3 (es) 1994-02-08 1995-02-06 Utilizacion de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.
JP7520985A JPH08511561A (ja) 1994-02-08 1995-02-06 ２，４−ジ置換フェノール誘導体の５−リボキシゲナーゼ阻害剤としての使用
DE69524709T DE69524709T2 (de) 1994-02-08 1995-02-06 Verwendung von derivaten von 2,4-disubstituierten phenolen als 5-lipoxygenaseinhibitoren
BR9505842A BR9505842A (pt) 1994-02-08 1995-02-06 Composição inibidora de 5-lipoxigenase,composição para o tratamento de uma doença causada por leucotrienos e método de tratamento de um paciente
US08/997,635 US5985937A (en) 1994-02-08 1997-12-23 Use of 2,4-distributed phenol derivatives as 5-lipoxygenase inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09400217A ES2087019B1 (es) 1994-02-08 1994-02-08 Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.

Publications (2)

Publication Number Publication Date
ES2087019A1 true ES2087019A1 (es) 1996-07-01
ES2087019B1 ES2087019B1 (es) 1997-03-16

Family

ID=8285128

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09400217A Expired - Fee Related ES2087019B1 (es) 1994-02-08 1994-02-08 Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.
ES95908286T Expired - Lifetime ES2171532T3 (es) 1994-02-08 1995-02-06 Utilizacion de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES95908286T Expired - Lifetime ES2171532T3 (es) 1994-02-08 1995-02-06 Utilizacion de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.

Country Status (11)

Country Link
US (1) US5985937A (es)
EP (1) EP0707849B1 (es)
JP (1) JPH08511561A (es)
AT (1) ATE210974T1 (es)
AU (1) AU706305B2 (es)
BR (1) BR9505842A (es)
DE (1) DE69524709T2 (es)
ES (2) ES2087019B1 (es)
MX (1) MX9504248A (es)
NZ (1) NZ279509A (es)
WO (1) WO1995021610A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003075905A1 (es) * 2002-03-14 2003-09-18 Bobel 246, S.L. Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la expresion de l-selectinas y de la isoforma inductible de la sintasa del oxido nitrico

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2134107C1 (ru) * 1998-10-12 1999-08-10 Тихоокеанский институт биоорганической химии Дальневосточного отделения РАН Препарат "гистохром" для лечения воспалительных заболеваний сетчатки и роговицы глаз
DE10040051A1 (de) * 2000-08-11 2002-02-21 Basf Ag Derivate des 4-(Trifluormethyl)-phenols sowie Derivate des 4-(Trifluormethylphenyl)-2-(tetrahydropyranyl)ethers und Verfahren zu ihre Herstellung
US6696466B1 (en) 2000-09-07 2004-02-24 Leslie Joe Dunaway Methods of treating select neuronal inflammatory disorders using hydroxyalkylquinolines
CA2632561C (en) * 2005-12-19 2015-01-27 The University Of Liverpool Substituted propofol derivatives as analgesics
BRPI0811284A2 (pt) * 2007-05-09 2015-01-20 Pharmacofore Inc Compostos terapêuticos
PL2146946T3 (pl) * 2007-05-09 2011-04-29 Pharmacofore Inc (-)-Stereoizomer 2,6-di-sec-butylofenolu i jego analogi
ES2396360T3 (es) 2008-10-09 2013-02-21 Industrial Farmaceutica Cantabria, S.A. Composición micronizada de un derivado de fenol 2,4-di sustituido
AU2010241567B2 (en) 2009-04-29 2013-10-31 Amarin Pharmaceuticals Ireland Limited Pharmaceutical compositions comprising EPA and a cardiovascular agent and methods of using the same
WO2021206549A1 (en) 2020-04-07 2021-10-14 Lin wen zhi Use of phenol in treatment of microbially induced dyspnoea
NL2025295B1 (en) * 2020-04-07 2021-10-25 Zhi Lin Wen Use of phenol in treatment of microbially induced dyspnoea

Citations (2)

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Publication number Priority date Publication date Assignee Title
US4029816A (en) * 1975-11-25 1977-06-14 Merck & Co., Inc. Substituted 2-aminomethyl-6-iodophenols
EP0147892A2 (en) * 1983-12-16 1985-07-10 Bislak, S.A. Process for preparing and therapeutical applications of the 2,4,6-triiodophenol

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
US4755524A (en) * 1986-01-31 1988-07-05 G. D. Searle & Co. Novel phenolic thioethers as inhibitors of 5-lipoxygenase
DE68907095T2 (de) * 1988-03-21 1994-01-05 Boehringer Ingelheim Pharma Verbindungen zur Verhinderung der Biosynthese von der Lipoxygenase abgeleiteten Metaboliten der Arachidonsäure.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029816A (en) * 1975-11-25 1977-06-14 Merck & Co., Inc. Substituted 2-aminomethyl-6-iodophenols
EP0147892A2 (en) * 1983-12-16 1985-07-10 Bislak, S.A. Process for preparing and therapeutical applications of the 2,4,6-triiodophenol

Non-Patent Citations (3)

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Title
J.C. COLBERT. The iodination of 4-hydroxybiphenil. Jour. of Amer. Chem. Soc. Vol. 66, n‘ 1, 11 Enero 1994, pßginas 122-124. Pßginas 123 y 124 *
M. TASHIRO et al. "Studies on selective prep. of aromatic compounds". Jour. of Org. Chem. Vol. 42, n‘ 5, 4 Marzo 77, pßginas 835-838. Pßgina 838, columna derecha, pßrrafo 4 *
T. SCHAEFER et al. A proton magnetic resonance estimate of the extent of intramolecular hydrogen honding in derivatives of 2-(trifluoromethyl) phenol. Canadian journal of chemistry. Vol. n‘ 54, n‘ 14, 1976, pßginas 2243-48. Tabla 1 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003075905A1 (es) * 2002-03-14 2003-09-18 Bobel 246, S.L. Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la expresion de l-selectinas y de la isoforma inductible de la sintasa del oxido nitrico

Also Published As

Publication number Publication date
AU706305B2 (en) 1999-06-10
DE69524709T2 (de) 2002-08-08
EP0707849B1 (en) 2001-12-19
ATE210974T1 (de) 2002-01-15
ES2171532T3 (es) 2002-09-16
MX9504248A (es) 1997-04-30
WO1995021610A1 (es) 1995-08-17
US5985937A (en) 1999-11-16
ES2087019B1 (es) 1997-03-16
AU1666295A (en) 1995-08-29
EP0707849A1 (en) 1996-04-24
JPH08511561A (ja) 1996-12-03
NZ279509A (en) 1999-09-29
DE69524709D1 (de) 2002-01-31
BR9505842A (pt) 1996-02-13

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