ES2085439T3 - Acilasa gl-7aca. - Google Patents

Acilasa gl-7aca.

Info

Publication number
ES2085439T3
ES2085439T3 ES91309666T ES91309666T ES2085439T3 ES 2085439 T3 ES2085439 T3 ES 2085439T3 ES 91309666 T ES91309666 T ES 91309666T ES 91309666 T ES91309666 T ES 91309666T ES 2085439 T3 ES2085439 T3 ES 2085439T3
Authority
ES
Spain
Prior art keywords
glu
acilase
7aca
aca
gln
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91309666T
Other languages
English (en)
Inventor
Ichiro Aramori
Masao Fukagawa
Hiroki Ono
Yosuke Ishitani
Mana Tsumura
Morita Iwami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2085439T3 publication Critical patent/ES2085439T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position

Abstract

UNA ACILASA GL-7ACA QUE TIENE LAS SIGUIENTES CARACTERISTICAS: (A) ES CAPAZ DE CATALIZAR LA CONVERSION ENZIMATICA DE GLUTARILO 7-ACA, ADIPILO 7-ACA Y SUCCINILO 7-ACA, EN ACIDO 7-AMINOCEFALOSPORANICO, (B) TIENE UN PESO MOLECULAR DE 70.000 DALROL (SDS-PAGE) Y (C) TIENE UNA SECUENCIA AMINOACIDA TERMINAL DE N DE LA MISMA: GLN-SER-GLU-GLN-GLU-LYS-ALA-GLU-GLU-. TAMBIEN SE PRESENTA UN PROCESO PARA LA PRODUCCION DE ACILASA GL-7ACA.
ES91309666T 1990-10-22 1991-10-18 Acilasa gl-7aca. Expired - Lifetime ES2085439T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909022907A GB9022907D0 (en) 1990-10-22 1990-10-22 Novel gl-7aca acylase

Publications (1)

Publication Number Publication Date
ES2085439T3 true ES2085439T3 (es) 1996-06-01

Family

ID=10684121

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91309666T Expired - Lifetime ES2085439T3 (es) 1990-10-22 1991-10-18 Acilasa gl-7aca.

Country Status (9)

Country Link
US (2) US5310659A (es)
EP (1) EP0482844B1 (es)
JP (1) JP3030982B2 (es)
AT (1) ATE133710T1 (es)
DE (1) DE69116795T2 (es)
DK (1) DK0482844T3 (es)
ES (1) ES2085439T3 (es)
GB (1) GB9022907D0 (es)
GR (1) GR3018858T3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW400384B (en) * 1993-11-01 2000-08-01 Fujisawa Pharmaceutical Co A new cephalosporin C acylase
EP0991752A2 (en) * 1997-09-09 2000-04-12 Biochemie Gesellschaft M.B.H. Esterase free enzymes
ES2252302T3 (es) * 2000-09-22 2006-05-16 Bristol-Myers Squibb Company Amidasa de glutaril cefalosporina a partir de pseudomonas diminuta bs-203.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA979832A (en) * 1971-05-31 1975-12-16 Kunio Matsumoto Production of 7-amino desacetoxy cephalosporanic acid from bacillus
JPS60110292A (ja) * 1983-11-22 1985-06-15 Asahi Chem Ind Co Ltd セフアロスポリン・アシラ−ゼ産生遺伝情報を担うｄνａ断片
KR0173124B1 (ko) * 1989-04-04 1999-02-01 카알 더블유. 라우쉬 7-아미노 세팔로스포란산의 효소적 제조방법

Also Published As

Publication number Publication date
DK0482844T3 (da) 1996-02-19
DE69116795D1 (de) 1996-03-14
EP0482844B1 (en) 1996-01-31
EP0482844A3 (en) 1993-01-13
JP3030982B2 (ja) 2000-04-10
GB9022907D0 (en) 1990-12-05
ATE133710T1 (de) 1996-02-15
JPH0584077A (ja) 1993-04-06
GR3018858T3 (en) 1996-05-31
US5312750A (en) 1994-05-17
DE69116795T2 (de) 1996-05-30
EP0482844A2 (en) 1992-04-29
US5310659A (en) 1994-05-10

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