ES2084940T3 - Uso de la rapamicina para el tratamiento de la leucemia/linfoma de las celulas t adultas. - Google Patents
Uso de la rapamicina para el tratamiento de la leucemia/linfoma de las celulas t adultas.Info
- Publication number
- ES2084940T3 ES2084940T3 ES92305287T ES92305287T ES2084940T3 ES 2084940 T3 ES2084940 T3 ES 2084940T3 ES 92305287 T ES92305287 T ES 92305287T ES 92305287 T ES92305287 T ES 92305287T ES 2084940 T3 ES2084940 T3 ES 2084940T3
- Authority
- ES
- Spain
- Prior art keywords
- lymphoma
- rapamicine
- treatment
- adult leukemia
- atl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
ESTE INVENTO PROPORCIONA UN METODO PARA TRATAR CELULAS T ADULTAS DE LEUCEMIA/LINFOMA (ATL) EN UN MAMIFERO QUE LO NECESITE QUE COMPRENDE LA ADMINISTACION DE UNA CANTIDAD ANTIPROLIFERATIVA DE RAPAMICIN Y ES PARTICULARMENTE UTIL EN ATAJAR O HACER REMITIR ATL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71777391A | 1991-06-18 | 1991-06-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2084940T3 true ES2084940T3 (es) | 1996-05-16 |
Family
ID=24883429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92305287T Expired - Lifetime ES2084940T3 (es) | 1991-06-18 | 1992-06-09 | Uso de la rapamicina para el tratamiento de la leucemia/linfoma de las celulas t adultas. |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0525960B1 (es) |
JP (1) | JP2562548B2 (es) |
KR (1) | KR930000115A (es) |
AT (1) | ATE135583T1 (es) |
AU (1) | AU651698B2 (es) |
CA (1) | CA2071456A1 (es) |
CZ (1) | CZ281663B6 (es) |
DE (1) | DE69209183T2 (es) |
DK (1) | DK0525960T3 (es) |
ES (1) | ES2084940T3 (es) |
GR (1) | GR3019749T3 (es) |
HK (1) | HK108897A (es) |
HU (1) | HU214326B (es) |
IE (1) | IE71646B1 (es) |
IL (1) | IL102185A (es) |
MX (1) | MX9202939A (es) |
NZ (1) | NZ243175A (es) |
SG (1) | SG43072A1 (es) |
SK (1) | SK279804B6 (es) |
ZA (1) | ZA924369B (es) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5177203A (en) * | 1992-03-05 | 1993-01-05 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents |
US5349060A (en) * | 1993-01-07 | 1994-09-20 | American Home Products Corporation | Rapamycin 31-ester with N,N-dimethylglycine derivatives useful as immunosuppressive agents |
US5252579A (en) * | 1993-02-16 | 1993-10-12 | American Home Products Corporation | Macrocyclic immunomodulators |
US5504091A (en) * | 1993-04-23 | 1996-04-02 | American Home Products Corporation | Biotin esters of rapamycin |
JPH08509499A (ja) | 1993-04-23 | 1996-10-08 | アボツト・ラボラトリーズ | ラパマイシン結合体及び抗体 |
US7279561B1 (en) | 1993-04-23 | 2007-10-09 | Wyeth | Anti-rapamycin monoclonal antibodies |
US5387680A (en) * | 1993-08-10 | 1995-02-07 | American Home Products Corporation | C-22 ring stabilized rapamycin derivatives |
CA2175215C (en) * | 1993-11-19 | 2008-06-03 | Yat Sun Or | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
US5561138A (en) | 1994-12-13 | 1996-10-01 | American Home Products Corporation | Method of treating anemia |
BE1009856A5 (fr) | 1995-07-14 | 1997-10-07 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule. |
US5780462A (en) * | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
US5922730A (en) * | 1996-09-09 | 1999-07-13 | American Home Products Corporation | Alkylated rapamycin derivatives |
AU4919597A (en) * | 1996-10-31 | 1998-05-22 | American Home Products Corporation | Synergistic composition comprising rapamycin and calcitriol |
CN1245423A (zh) | 1996-12-30 | 2000-02-23 | 巴特勒纪念研究院 | 采用吸入法治疗肿瘤的制剂和方法 |
CA2230748C (en) * | 1997-03-14 | 2010-08-03 | American Home Products Corporation | Rapamycin formulations for oral administration |
US5985325A (en) * | 1997-06-13 | 1999-11-16 | American Home Products Corporation | Rapamycin formulations for oral administration |
RU2184541C2 (ru) * | 1997-06-13 | 2002-07-10 | Американ Хоум Продактс Корпорейшн | Препараты рапамицина для орального применения |
CN1296413A (zh) * | 1998-02-04 | 2001-05-23 | 应用遗传学及皮肤学公司 | 调节应答于基因毒物的细胞因子释放的组合物和方法 |
US6015809A (en) * | 1998-08-17 | 2000-01-18 | American Home Products Corporation | Photocyclized rapamycin |
US6331547B1 (en) | 1999-08-18 | 2001-12-18 | American Home Products Corporation | Water soluble SDZ RAD esters |
DE60142677D1 (de) | 2000-01-14 | 2010-09-09 | Univ Pennsylvania | O-methylierte rapamycinderivate zur milderung oder vermeidung lymphoproliferativer erkrankungen |
US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
US6670355B2 (en) | 2000-06-16 | 2003-12-30 | Wyeth | Method of treating cardiovascular disease |
JP2004509898A (ja) | 2000-09-19 | 2004-04-02 | ワイス | 水溶性ラパマイシンエステル |
US6399625B1 (en) | 2000-09-27 | 2002-06-04 | Wyeth | 1-oxorapamycins |
US6399626B1 (en) | 2000-10-02 | 2002-06-04 | Wyeth | Hydroxyesters of 7-desmethylrapamycin |
TWI286074B (en) | 2000-11-15 | 2007-09-01 | Wyeth Corp | Pharmaceutical composition containing CCI-779 as an antineoplastic agent |
PL367267A1 (en) * | 2001-06-01 | 2005-02-21 | Wyeth | Antineoplastic combinations |
UA77200C2 (en) | 2001-08-07 | 2006-11-15 | Wyeth Corp | Antineoplastic combination of cci-779 and bkb-569 |
US6680330B2 (en) | 2001-08-22 | 2004-01-20 | Wyeth | Rapamycin dialdehydes |
ES2246409T3 (es) | 2001-08-22 | 2006-02-16 | Wyeth | 29-enoles de rapamicina. |
AU2003247483A1 (en) * | 2002-05-30 | 2003-12-31 | The Children's Hospital Of Philadelphia | Methods for treatment of acute lymphocytic leukemia |
PT1553940E (pt) | 2002-07-30 | 2008-05-09 | Wyeth Corp | Formulações parentéricas contendo um hidroxi-éster de rapamicina |
AR042938A1 (es) | 2003-02-06 | 2005-07-06 | Wyeth Corp | Uso del cci-779 en el tratamiento de la fibrosis hepatica |
CN1942478A (zh) | 2004-04-14 | 2007-04-04 | 惠氏公司 | 用于制备与二羧酸的纳巴霉素42-酯和fk-506 32-酯的方法,用于纳巴霉素配合物的前体和抗体 |
ME02695B (me) | 2004-05-13 | 2017-10-20 | Icos Corp | Hinazolinoni kao inhibitori humane fosfatidilonozitol 3- delta kinaze |
CA2567883A1 (en) * | 2004-05-25 | 2005-12-15 | Icos Corporation | Methods for treating and/or preventing aberrant proliferation of hematopoietic cells |
CN101360495B (zh) | 2005-11-14 | 2012-03-14 | 阿里亚德医药股份有限公司 | 对癌症病人给药mTOR抑制剂 |
US7867988B2 (en) | 2006-09-13 | 2011-01-11 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
JP5794919B2 (ja) | 2008-11-13 | 2015-10-14 | ギリアード カリストガ エルエルシー | 血液学的な悪性疾患のための療法 |
US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
CN102439012A (zh) | 2009-03-24 | 2012-05-02 | 吉里德卡利斯托加公司 | 2-嘌呤基-3-甲苯基-喹唑啉酮衍生物的阻转异构体和使用方法 |
EP2416792A4 (en) | 2009-04-10 | 2012-10-24 | Haiyan Qi | NEW ANTI-AGING APPROACHES AND METHOD FOR IDENTIFYING THEM |
EP2421536B1 (en) | 2009-04-20 | 2015-08-26 | Gilead Calistoga LLC | Methods of treatment for solid tumors |
AU2010276160A1 (en) | 2009-07-21 | 2012-02-09 | Gilead Calistoga Llc | Treatment of liver disorders with PI3K inhibitors |
AU2012351728A1 (en) | 2011-12-16 | 2014-06-19 | Oncology Institute Of Southern Switzerland | Combination of inotuzumab ozogamicin and torisel for the treatment of cancer |
EA201691327A1 (ru) | 2012-03-05 | 2017-03-31 | Джилид Калистога Ллс | Полиморфные формы (s)-2-(1-(9h-пурин-6-иламино)пропил)-5-фтор-3-фенилхиназолин-4(3h)-она |
CA2934534A1 (en) | 2013-12-20 | 2015-06-25 | Gilead Calistoga Llc | Polymorphic forms of a hydrochloride salt of (s)-2-(1-(9h-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3h)-one |
CN105849108A (zh) | 2013-12-20 | 2016-08-10 | 吉利德卡利斯托加公司 | 磷脂酰肌醇3-激酶抑制剂的制备方法 |
MA40059A (fr) | 2014-06-13 | 2015-12-17 | Gilead Sciences Inc | Inhibiteurs de la phosphatidylinositol 3-kinase |
SG11201908226XA (en) | 2017-02-10 | 2019-10-30 | Mount Tam Therapeutics Inc | Rapamycin analog |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
BE877700A (fr) * | 1978-11-03 | 1980-01-14 | Ayerst Mckenna & Harrison | Compositions pharmaceutiques a base de rapamycine pour le traitement de tumeurs carcinogenes |
GB8610114D0 (en) * | 1986-04-25 | 1986-05-29 | Esselte Letraset Ltd | Sign-making materials |
-
1992
- 1992-06-09 SG SG1996003282A patent/SG43072A1/en unknown
- 1992-06-09 DE DE69209183T patent/DE69209183T2/de not_active Expired - Fee Related
- 1992-06-09 AT AT92305287T patent/ATE135583T1/de active
- 1992-06-09 DK DK92305287.2T patent/DK0525960T3/da active
- 1992-06-09 ES ES92305287T patent/ES2084940T3/es not_active Expired - Lifetime
- 1992-06-09 EP EP92305287A patent/EP0525960B1/en not_active Expired - Lifetime
- 1992-06-12 IL IL102185A patent/IL102185A/xx not_active IP Right Cessation
- 1992-06-15 CZ CS921824A patent/CZ281663B6/cs unknown
- 1992-06-15 ZA ZA924369A patent/ZA924369B/xx unknown
- 1992-06-15 SK SK1824-92A patent/SK279804B6/sk unknown
- 1992-06-16 KR KR1019920010398A patent/KR930000115A/ko active IP Right Grant
- 1992-06-16 AU AU18255/92A patent/AU651698B2/en not_active Ceased
- 1992-06-17 MX MX9202939A patent/MX9202939A/es not_active IP Right Cessation
- 1992-06-17 JP JP4157854A patent/JP2562548B2/ja not_active Expired - Lifetime
- 1992-06-17 NZ NZ243175A patent/NZ243175A/en unknown
- 1992-06-17 HU HU9202023A patent/HU214326B/hu not_active IP Right Cessation
- 1992-06-17 CA CA002071456A patent/CA2071456A1/en not_active Abandoned
- 1992-07-01 IE IE921957A patent/IE71646B1/en not_active IP Right Cessation
-
1996
- 1996-04-24 GR GR960401146T patent/GR3019749T3/el unknown
-
1997
- 1997-06-26 HK HK108897A patent/HK108897A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HU9202023D0 (en) | 1992-09-28 |
CZ281663B6 (cs) | 1996-12-11 |
SK279804B6 (sk) | 1999-04-13 |
IE71646B1 (en) | 1997-02-26 |
DE69209183D1 (de) | 1996-04-25 |
SG43072A1 (en) | 1997-10-17 |
KR930000115A (ko) | 1993-01-15 |
MX9202939A (es) | 1994-05-31 |
IE921957A1 (en) | 1992-12-30 |
HU214326B (hu) | 1998-03-02 |
JP2562548B2 (ja) | 1996-12-11 |
GR3019749T3 (en) | 1996-07-31 |
NZ243175A (en) | 1997-06-24 |
EP0525960A1 (en) | 1993-02-03 |
AU1825592A (en) | 1992-12-24 |
IL102185A (en) | 1997-09-30 |
DK0525960T3 (da) | 1996-04-15 |
CZ182492A3 (en) | 1993-12-15 |
DE69209183T2 (de) | 1996-08-08 |
EP0525960B1 (en) | 1996-03-20 |
ATE135583T1 (de) | 1996-04-15 |
JPH05170771A (ja) | 1993-07-09 |
ZA924369B (en) | 1993-12-15 |
HUT61480A (en) | 1993-01-28 |
SK182492A3 (en) | 1994-10-05 |
AU651698B2 (en) | 1994-07-28 |
CA2071456A1 (en) | 1992-12-19 |
HK108897A (en) | 1997-08-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2084940T3 (es) | Uso de la rapamicina para el tratamiento de la leucemia/linfoma de las celulas t adultas. | |
LV11116A (lv) | Virsmas notirisana ar apstarojuma palidzibu | |
DK0414289T3 (da) | Spirocykliske, antipsykotiske midler | |
ATE141812T1 (de) | Fallschutzgerat | |
DE69308109D1 (de) | Sicherheitsgurtführung | |
DE68908231D1 (de) | Roentgenuntersuchungsapparat mit einstellbarer schlitzfoermiger blende. | |
DE68904029D1 (de) | Sicherheitsgurtvorrichtung. | |
ES2089723T3 (es) | 29-demetoxirapamicina para inducir la inmunodepresion. | |
DE68904971D1 (de) | Vorrichtung zum stapeln von flachen gegenstaenden, wie briefe. | |
FI870506A (fi) | Saollningsanlaeggning med sammanbyggd foerdelnings- och avskiljningsanordning. | |
DK0458589T3 (da) | Behandling af okulær hypertension med en okulær synergistisk kombination | |
DE69014221D1 (de) | Bandführungsvorrichtung. | |
PT656209E (pt) | Derivados de melatonina para uso no tratamento de perturbacoes de dessincronizacao | |
FI940519A0 (fi) | Interleukiini-10-analogien tai -antagonistien käyttö endotoksiinin taisuperantigeenin indusoiman toksisuuden hoitamiseksi | |
ATE285789T1 (de) | Mukosale zytotoxische t-lymphozytenantwort | |
FI903742A0 (fi) | Foerfarande foer diskontinuerlig framstaellning av l-carnitin pao mikrobiologisk vaeg. | |
DE59200188D1 (de) | Gurtaufroller mit Komforteinrichtung. | |
DE58900132D1 (de) | Verfahren und vorrichtung zum montieren von riemen an riementrieben. | |
ATE83907T1 (de) | Vorrichtung zum offenhalten eines ureterotomieschnitts. | |
DE69013938D1 (de) | Sicherheitsgurtvorrichtung. | |
DE69208404D1 (de) | Vorrichtung zur Unterdrückung von Riemengeräuschen und -schwingungen | |
ES1013657Y (es) | Aparato de gimnasia por poleas. | |
SE9200281D0 (sv) | Anordning foer rullstol med bilbaelte | |
ATE178733T1 (de) | Vorrichtung zur informationsvermittlung | |
ES271525Y (es) | Dispositivo de regulacion de la inclinacion relativa de dos organos y especialmente de la base y del respaldo de un asiento de automovil. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 525960 Country of ref document: ES |