ES2077785T3 - Monomero de terc-butiloxicarbonil-l-tirosil-peptidoglucano y derivados de 125i-marcados del mismos, su preparacion y uso. - Google Patents

Monomero de terc-butiloxicarbonil-l-tirosil-peptidoglucano y derivados de 125i-marcados del mismos, su preparacion y uso.

Info

Publication number
ES2077785T3
ES2077785T3 ES91121871T ES91121871T ES2077785T3 ES 2077785 T3 ES2077785 T3 ES 2077785T3 ES 91121871 T ES91121871 T ES 91121871T ES 91121871 T ES91121871 T ES 91121871T ES 2077785 T3 ES2077785 T3 ES 2077785T3
Authority
ES
Spain
Prior art keywords
preparation
monomer
thyrosyl
butyloxicarbonyl
peptidoglucan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91121871T
Other languages
English (en)
Inventor
Djurdjica Dr Ljevakovic
Branka Dr Vranesic
Jelka Dr Tomasevic
Ivo Dr Hrsak
Branko Dr Ladesic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pliva Farmaceutika dd
Original Assignee
Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd filed Critical Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd
Application granted granted Critical
Publication of ES2077785T3 publication Critical patent/ES2077785T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE AL NUEVO MONOMERO TERT-BUTILOXICARBONILO -L-TIROSILO-PEPTIDOGLICANO Y A SU DERIVATIVO BOC-TYR-PGM MARCADO ESTE EN LA PREPARACION DE PRODUCTOS FARMACEUTICOS DE ACTIVIDAD INMUNOESTIMULANTE Y ANTITUMOR.
ES91121871T 1990-12-21 1991-12-19 Monomero de terc-butiloxicarbonil-l-tirosil-peptidoglucano y derivados de 125i-marcados del mismos, su preparacion y uso. Expired - Lifetime ES2077785T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU242490 1990-12-21

Publications (1)

Publication Number Publication Date
ES2077785T3 true ES2077785T3 (es) 1995-12-01

Family

ID=25557920

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91121871T Expired - Lifetime ES2077785T3 (es) 1990-12-21 1991-12-19 Monomero de terc-butiloxicarbonil-l-tirosil-peptidoglucano y derivados de 125i-marcados del mismos, su preparacion y uso.

Country Status (13)

Country Link
US (1) US5290576A (es)
EP (1) EP0492478B1 (es)
JP (1) JPH05194596A (es)
CN (1) CN1062735A (es)
AT (1) ATE125270T1 (es)
CA (1) CA2058247A1 (es)
CZ (1) CZ394791A3 (es)
DE (1) DE69111401T2 (es)
ES (1) ES2077785T3 (es)
GR (1) GR3017349T3 (es)
HU (1) HU208160B (es)
PL (2) PL167043B1 (es)
RO (1) RO108348B1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6663866B1 (en) 1996-08-28 2003-12-16 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
US6558669B1 (en) 1996-08-28 2003-05-06 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
ATE194143T1 (de) * 1996-08-28 2000-07-15 Immunomedics Inc Stabile radioiodium-konjugate und verfahren zu deren herstellung
US7521531B2 (en) 1996-08-28 2009-04-21 Immunomedics, Inc. Methods for the purification of stable radioiodine conjugates
CZ301451B6 (cs) * 2005-10-18 2010-03-03 Ústav organické chemie a biochemie, Akademie ved CR Deriváty kyseliny glukosaminylmuramové
CN105132372B (zh) * 2015-08-28 2019-04-30 淄博金砖生物科技有限公司 一种诱导dc-cik细胞的化合物在肿瘤细胞免疫治疗中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310514A (en) * 1980-05-05 1982-01-12 Merck & Co., Inc. Immunologically active dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose derivatives and methods of preparation
YU62689A (en) * 1989-03-27 1991-02-28 Pliva Pharm & Chem Works N-acyl derivatives of peptidoglican monomer, their pharmaceutically acceptable salts, process for preparing thereof and their use as immunity modulators and immunoadjuvant

Also Published As

Publication number Publication date
EP0492478A2 (en) 1992-07-01
ATE125270T1 (de) 1995-08-15
HUT60509A (en) 1992-09-28
DE69111401D1 (de) 1995-08-24
CN1062735A (zh) 1992-07-15
HU914066D0 (en) 1992-03-30
HU208160B (en) 1993-08-30
US5290576A (en) 1994-03-01
DE69111401T2 (de) 1996-02-22
GR3017349T3 (en) 1995-12-31
CZ394791A3 (en) 1993-02-17
EP0492478B1 (en) 1995-07-19
JPH05194596A (ja) 1993-08-03
RO108348B1 (ro) 1994-04-28
EP0492478A3 (en) 1993-05-12
PL167043B1 (en) 1995-07-31
PL292898A1 (en) 1992-09-07
PL167068B1 (pl) 1995-07-31
CA2058247A1 (en) 1992-06-22

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