ES2075830T3 - Receptores para complejos inmunes, sus metodos de produccion y metodos de ensayo que los utilizan. - Google Patents

Receptores para complejos inmunes, sus metodos de produccion y metodos de ensayo que los utilizan.

Info

Publication number
ES2075830T3
ES2075830T3 ES87308829T ES87308829T ES2075830T3 ES 2075830 T3 ES2075830 T3 ES 2075830T3 ES 87308829 T ES87308829 T ES 87308829T ES 87308829 T ES87308829 T ES 87308829T ES 2075830 T3 ES2075830 T3 ES 2075830T3
Authority
ES
Spain
Prior art keywords
antigen
monoepitopic
antibody
methods
immune
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87308829T
Other languages
English (en)
Inventor
Edwin F Ullman
John Jelesko
Marcel R Pirio
Thomas D Kempe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25437826&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2075830(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of ES2075830T3 publication Critical patent/ES2075830T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/948—Sedatives, e.g. cannabinoids, barbiturates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/817—Steroids or hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products

Abstract

SE DESCRIBEN RECEPTORES QUE SON ANTICUERPOS QUE PRESENTAN UNA ACTIVIDAD ENLAZANTE DE UN INMUNOCOMPLEJO DE UN ANTIGENO DE UN MONOEPITOPICO Y UN ANTICUERPO PARA TAL ANTIGENO, QUE ES NOTABLEMENTE MAYOR QUE LA AFINIDAD ENLAZANTE DEL ANTIGENO MONOEPITOPICO O EL ANTICUERPO PARA EL ANTIGENO MONOEPITOPICO APARTE DEL INMUNOCOMPLEJO. NORMALMENTE EL ANTIGENO MONOEPITOPICO TIENE UN PESO MOLECULAR DE 1500 Y ES UN COMPUESTO ORGANICO. LOS ANTICUERPOS DE LA PRESENTE INVENCION SE UTILIZAN EN UN METODO PARA LA DETERMINACION DE UN ANTIGENO MONOEPITOPICO EN UNA MUESTRA SOSPECHOSA DE CONTENER TAL ANTIGENO. EL METODO CONSISTE EN FORMAR UN COMPLEJO SANDWICH INMUNE, QUE COMPRENDE EL ANTIGENO MONOEPITOPICO O UNO DE SUS ANALOGOS, UN PRIMER ANTICUERPO MONOCLONAL QUE SE UNE AL ANTIGENO MONOEPITOPICO, Y UN SEGUNDO ANTICUERPO MONOCLONAL QUE ES UN ANTICUERPO DE LA PRESENTE INVENCION Y DETECTOR DEL COMPLEJO SANDWICH INMUNE. TAMBIEN SE DESCRIBEN COMPOSICIONES DE LOS RECEPTORES Y EQUIPOS PARA USAR EN LA REALIZACION DE UN ENSAYO DE ACUERDO CON LA INVENCION, ASI COMO METODOS PARA OBTENER LOS RECEPTORES ANTERIORES.
ES87308829T 1986-10-09 1987-10-06 Receptores para complejos inmunes, sus metodos de produccion y metodos de ensayo que los utilizan. Expired - Lifetime ES2075830T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/916,777 US5223441A (en) 1986-10-09 1986-10-09 Receptors for immune complexes

Publications (1)

Publication Number Publication Date
ES2075830T3 true ES2075830T3 (es) 1995-10-16

Family

ID=25437826

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87308829T Expired - Lifetime ES2075830T3 (es) 1986-10-09 1987-10-06 Receptores para complejos inmunes, sus metodos de produccion y metodos de ensayo que los utilizan.

Country Status (7)

Country Link
US (2) US5223441A (es)
EP (1) EP0264219B1 (es)
JP (1) JP2793587B2 (es)
AT (1) ATE125949T1 (es)
CA (1) CA1340201C (es)
DE (1) DE3751432T2 (es)
ES (1) ES2075830T3 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5468651A (en) * 1987-11-28 1995-11-21 Cambridge Patent Developments Limited Method for determining haptens, use of method and components useful in method
DE3850784T2 (de) * 1987-11-28 1995-03-09 Cambridge Patent Dev Bestimmungsverfahren, seine verwendung und komponenten.
EP0386275A3 (en) * 1988-03-17 1990-10-03 Synbiotics Corporation Anti-idiotype intermediate method of making binding site mimics
WO1991019001A1 (en) * 1990-05-25 1991-12-12 British Technology Group Ltd Immunodiagnostic assay for rheumatoid arthritis
US5599677A (en) * 1993-12-29 1997-02-04 Abbott Laboratories Immunoassays for prostate specific antigen
US5817766A (en) * 1995-04-05 1998-10-06 Roche Diagnostic Systems, Inc. Reagents for a cannabinoid immunoassay
WO1996040662A2 (en) * 1995-06-07 1996-12-19 Cellpro, Incorporated Aminooxy-containing linker compounds and their application in conjugates
AU7730500A (en) * 1999-09-30 2001-04-30 Nanogen, Inc. Biomolecular attachment sites on microelectronic arrays and methods thereof
DE10054055A1 (de) * 2000-10-31 2002-05-23 Nmi Univ Tuebingen Verfahren zur Analyse von Proteinen
DE10122806A1 (de) * 2001-05-10 2002-11-14 Holger Kiesewetter Verfahren zum Nachweis von Blutzell-Antigenen und gegen diese gerichtete Antikörper
WO2003012396A2 (en) * 2001-08-01 2003-02-13 Chauhan Anil K Immune complexes
US7618788B2 (en) * 2002-05-10 2009-11-17 Millipore Corporation Proteome epitope tags and methods of use thereof in protein modification analysis
US7460960B2 (en) * 2002-05-10 2008-12-02 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
FI20022048A0 (fi) * 2002-11-18 2002-11-18 Valtion Teknillinen Ei-kompetetiivinen immunomääritys pienille analyyteille
WO2004071446A2 (en) * 2003-02-12 2004-08-26 Chauhan Anil K Immune complexes
EP1622941A2 (en) * 2003-03-20 2006-02-08 ImClone Systems Incorporated Method of producing an antibody to epidermal growth factor receptor
GB2404022B (en) * 2004-06-14 2005-08-10 Cozart Bioscience Ltd Competitive assays for the detection of methamphetamine group drugs
GB2404023B (en) * 2004-07-02 2005-07-06 Cozart Bioscience Ltd Delta-9-tetrahydrocannabinol detection method
JP5097557B2 (ja) * 2005-12-22 2012-12-12 ローム株式会社 免疫測定装置及び方法
US7855057B2 (en) * 2006-03-23 2010-12-21 Millipore Corporation Protein splice variant/isoform discrimination and quantitative measurements thereof
GB0707870D0 (en) 2007-04-23 2007-05-30 Selected Antibodies Ltd Assay Devices and Methods and Components for use Therein
FI20085579A0 (fi) * 2008-06-12 2008-06-12 Valtion Teknillinen Kannabiskäytön toteaminen
DE102008049601A1 (de) * 2008-09-30 2010-04-01 Siemens Healthcare Diagnostics Products Gmbh Antikörper zur Bestimmung des Prothrombin-Fragments F2/F1+2 in einem homogenen Immunoassay
AU2012310880B2 (en) 2011-09-21 2015-12-03 Fujirebio Inc. Antibody against affinity complex
JP6031944B2 (ja) * 2012-10-30 2016-11-24 東ソー株式会社 抗イムノコンプレックス抗体、それを産生するハイブリドーマ、及びそれらの製造方法
JP6221466B2 (ja) * 2013-07-29 2017-11-01 東ソー株式会社 ハプテンの測定方法
US9933445B1 (en) 2016-05-16 2018-04-03 Hound Labs, Inc. System and method for target substance identification
CA3031355C (en) 2016-07-29 2023-05-23 Diazyme Laboratories, Inc. Methods and compositions for assaying vitamin d
US11026596B1 (en) 2017-05-19 2021-06-08 Hound Labs, Inc. Detection and measurement of target substance in exhaled breath
US11187711B1 (en) * 2017-09-11 2021-11-30 Hound Labs, Inc. Analyte detection from breath samples
US11426097B1 (en) 2018-10-17 2022-08-30 Hound Labs, Inc. Rotary valve assemblies and methods of use for breath sample cartridge systems
JPWO2021182555A1 (es) * 2020-03-12 2021-09-16
WO2021182558A1 (ja) * 2020-03-12 2021-09-16 日立化成ダイアグノスティックス・システムズ株式会社 試料中の対象物質を免疫測定するための方法及びキット
US11933731B1 (en) 2020-05-13 2024-03-19 Hound Labs, Inc. Systems and methods using Surface-Enhanced Raman Spectroscopy for detecting tetrahydrocannabinol
US11806711B1 (en) 2021-01-12 2023-11-07 Hound Labs, Inc. Systems, devices, and methods for fluidic processing of biological or chemical samples using flexible fluidic circuits

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508132A (en) 1974-05-20 1978-04-19 Technicon Instr Analysis of biological fluids
GB1590524A (en) 1976-11-24 1981-06-03 Nat Res Dev Assay of immune complexes
US4281061A (en) 1979-07-27 1981-07-28 Syva Company Double antibody for enhanced sensitivity in immunoassay
DE3062976D1 (en) * 1979-09-26 1983-06-09 Hoffmann La Roche Tetrahydrocannabinol derivatives, 125i-labeled tetrahydrocannabinol derivatives, immunogens yielding antibodies and radioimmunoassay for detecting cannabinoids
US4486530A (en) 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4459359A (en) 1981-11-19 1984-07-10 New York Blood Center, Inc. Sensitive immunoassays of antigens or antibodies sequestered within immune complexes
EP0091760B1 (en) * 1982-04-09 1986-07-02 FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. Anti immune complex antibody and preparation thereof
US4514505A (en) 1982-05-21 1985-04-30 The Trustees Of Columbia University In The City Of New York Monoclonal antibody mixtures and use thereof for enhanced sensitivity immunoassays
US4420461A (en) 1982-05-26 1983-12-13 Ortho Diagnostic Systems Inc. Agglutination-inhibition test kit for detecting immune complexes
US4471058A (en) 1982-07-26 1984-09-11 Board Of Trustees Operating Michigan State University Method for the detection and/or determination of a polyvalent antigen using at least two different monoclonal antibodies
US4474892A (en) 1983-02-16 1984-10-02 Board Of Trustees Of The Leland Stanford Junior University Two-site immunoassays using monoclonal antibodies of different classes or subclasses and test kits for performing same
US4536479A (en) 1983-03-22 1985-08-20 E. I. Du Pont De Nemours And Company Use of anti-idiotype antibodies in immunoassays
GB8408193D0 (en) * 1984-03-30 1984-05-10 Cambridge Patent Dev Antibodies
GB2161165A (en) * 1984-06-12 1986-01-08 Cambridge Patent Dev Secondary antibodies
DE3433652A1 (de) * 1984-09-13 1986-03-20 Boehringer Mannheim Gmbh, 6800 Mannheim Immunchemisches messverfahren fuer haptene und proteine
GB2171999A (en) * 1985-03-04 1986-09-10 Iq Antibodies
GB2177094B (en) * 1985-07-05 1990-03-07 Cambridge Patent Dev Limited Diagnostic kits incorporating polyclonal antibodies.
AU7485987A (en) * 1986-05-28 1987-12-22 Murex Corp. Method for producing monoclonal antibodies to an immunogenic antibody-antigen conjunction
GB8616174D0 (en) * 1986-07-02 1986-08-06 Antibody Technology Ltd Monoclonal antibodies

Also Published As

Publication number Publication date
EP0264219A3 (en) 1990-04-11
JPS63112599A (ja) 1988-05-17
EP0264219A2 (en) 1988-04-20
DE3751432D1 (de) 1995-09-07
DE3751432T2 (de) 1996-03-21
CA1340201C (en) 1998-12-15
US5223441A (en) 1993-06-29
ATE125949T1 (de) 1995-08-15
JP2793587B2 (ja) 1998-09-03
EP0264219B1 (en) 1995-08-02
US6326159B1 (en) 2001-12-04

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