ES2073601T3 - Peptidos que inhiben la coagulacion sanguinea, procedimiento para su preparacion y su uso. - Google Patents

Peptidos que inhiben la coagulacion sanguinea, procedimiento para su preparacion y su uso.

Info

Publication number
ES2073601T3
ES2073601T3 ES91102607T ES91102607T ES2073601T3 ES 2073601 T3 ES2073601 T3 ES 2073601T3 ES 91102607 T ES91102607 T ES 91102607T ES 91102607 T ES91102607 T ES 91102607T ES 2073601 T3 ES2073601 T3 ES 2073601T3
Authority
ES
Spain
Prior art keywords
glu
asp
atoms
phe
bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91102607T
Other languages
English (en)
Inventor
Werner Dr Stuber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Application granted granted Critical
Publication of ES2073601T3 publication Critical patent/ES2073601T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE TRATA DE PEPTIDOS DE LA FORMULA I A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15 DONDE A1 HIDROGENO, CISTEINA, ACETILCISTEINA, UNO O DOS GRUPOS ALQUILO CON 1-4 ATOMOS DE C, UNO GRUPO ACIL CON 2-10 ATOMOS DE C, Y UN OTRO GRUPO CARBOXIL O EN EL GRUPO USUAL DE PROTECCION DEL PEPTIDO. A2 UN ENLACE ASN, ASP, GLN, O GLU A3 UN ENLACE GLY, O ALA, A4 GLU O ASP, A5 PHE, TYR, TRP, PGL (FENILGLICIN) O NAL (NAFTILALANIN) A6 GLU O ASP A7 GLU, ASP, PRO, O ALA, A8 ILE, LEU, VAL, NLE, O PHE, A9 PRO O HYP, A10 GLU, O ASP, A11 GLU, O ASP, A12 PHE (SO SUB 3H) O PHE(PO SUB 3H SUB 2) (PREFERENTEMENTE EN POSICION-P) O PGL(SO SUB 3H) O PGL(PO SUB 3H SUB 2) PREFERENTEMENTE EN POSICION-P) A13 UN ENLACE LEU, ILE, VAL, O ALA, A14 UN ENLACE GLN, ASN, GLU, ASP, O CYS Y A15 CYS, CYS-AMID, UN GRUPO OH DE ALFA-GRUPO CARBOXIL, LIBRE O CON BAJO ALCOHOL ESTERIFICADO CON HASTA 4 ATOMOS DE C, QUE PUEDE ESTAR COMO FUNCION CARBOXAMIDA, CUYO HIDROGENO PUEDE SER SUSTITUIDO EN CUALQUIER CASO POR GRUPOS ALQUILO CON HASTA 4 ATOMOS DE C. SE DESCRIBE TAMBIEN UN PROCEDIMIENTO PARA SU FABRICACION. ESTOS PEPTIDOS INHIBEN LA COAGULACION DE LA SANGRE Y PUEDEN SER UTILIZADOS COMO ANTICOAGULANTES.
ES91102607T 1990-02-22 1991-02-22 Peptidos que inhiben la coagulacion sanguinea, procedimiento para su preparacion y su uso. Expired - Lifetime ES2073601T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4005591A DE4005591A1 (de) 1990-02-22 1990-02-22 Die blutgerinnung inhibierende peptide, verfahren zu ihrer herstellung und ihre verwendung

Publications (1)

Publication Number Publication Date
ES2073601T3 true ES2073601T3 (es) 1995-08-16

Family

ID=6400736

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91102607T Expired - Lifetime ES2073601T3 (es) 1990-02-22 1991-02-22 Peptidos que inhiben la coagulacion sanguinea, procedimiento para su preparacion y su uso.

Country Status (11)

Country Link
EP (1) EP0443598B1 (es)
JP (1) JPH0770181A (es)
KR (1) KR910021412A (es)
AT (1) ATE122684T1 (es)
AU (1) AU640739B2 (es)
CA (1) CA2036815A1 (es)
DE (2) DE4005591A1 (es)
DK (1) DK0443598T3 (es)
ES (1) ES2073601T3 (es)
IE (1) IE66493B1 (es)
PT (1) PT96836B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4103649A1 (de) * 1991-02-07 1992-08-13 Basf Ag Neue antikoagulatorisch wirksame peptide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
WO1991001142A1 (en) * 1989-07-20 1991-02-07 Biogen, Inc. Combinations and methods for treating or preventing thrombotic diseases
WO1991002348A1 (en) * 1989-08-07 1991-02-21 Motorola, Inc. Speech recognition using spectral line frequencies
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin

Also Published As

Publication number Publication date
CA2036815A1 (en) 1991-08-23
DK0443598T3 (da) 1995-09-25
AU640739B2 (en) 1993-09-02
DE4005591A1 (de) 1991-09-05
EP0443598A2 (de) 1991-08-28
AU7125591A (en) 1991-08-29
DE59105479D1 (de) 1995-06-22
PT96836A (pt) 1991-10-31
IE66493B1 (en) 1996-01-10
EP0443598B1 (de) 1995-05-17
ATE122684T1 (de) 1995-06-15
KR910021412A (ko) 1991-12-20
PT96836B (pt) 1998-07-31
EP0443598A3 (en) 1992-01-08
JPH0770181A (ja) 1995-03-14
IE910597A1 (en) 1991-08-28

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