ES2073097T3 - Procedimiento para la obtencion de esteres del acido (6s)-6,8-dihidroxioctanoico. - Google Patents

Procedimiento para la obtencion de esteres del acido (6s)-6,8-dihidroxioctanoico.

Info

Publication number
ES2073097T3
ES2073097T3 ES91119430T ES91119430T ES2073097T3 ES 2073097 T3 ES2073097 T3 ES 2073097T3 ES 91119430 T ES91119430 T ES 91119430T ES 91119430 T ES91119430 T ES 91119430T ES 2073097 T3 ES2073097 T3 ES 2073097T3
Authority
ES
Spain
Prior art keywords
acid
procedure
dihidroxioctanoico
esters
obtaining esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91119430T
Other languages
English (en)
Inventor
Friedhelm Dr Balkenhohl
Joachim Dr Paust
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Application granted granted Critical
Publication of ES2073097T3 publication Critical patent/ES2073097T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

FABRICACION DE (6S)-6, 8 ESTERES DE ACIDO DIHIDROXIOCTANO I (R ELEVADO 1 = ALQUILO, CICLOALQUILO, ARALQUILO O ARILO), EN LA MEDIDA EN QUE UN (3S)-3-DIESTER DE DIACIDO HIDROXIOCTANO II (R (AL CUADRADO) = UNO DE LOS RESTOS DE R ELEVADO 1) REDUCE CON UN HIDRURO COMPLEJO. LOS PRODUCTOS DEL PROCEDIMIENTO SIRVEN ESPECIALMENTE, COMO PRODUCTOS INTERMEDIOS PARA LA SINTESIS DE COMBINACIONES DEL TIPO DEL ACIDO DE LIPON.
ES91119430T 1990-11-24 1991-11-14 Procedimiento para la obtencion de esteres del acido (6s)-6,8-dihidroxioctanoico. Expired - Lifetime ES2073097T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4037440A DE4037440A1 (de) 1990-11-24 1990-11-24 Verfahren zur herstellung von (6s)-6,8-dihydroxyoctansaeureestern

Publications (1)

Publication Number Publication Date
ES2073097T3 true ES2073097T3 (es) 1995-08-01

Family

ID=6418861

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91119430T Expired - Lifetime ES2073097T3 (es) 1990-11-24 1991-11-14 Procedimiento para la obtencion de esteres del acido (6s)-6,8-dihidroxioctanoico.

Country Status (5)

Country Link
US (1) US5530143A (es)
EP (1) EP0487986B1 (es)
JP (1) JP3140113B2 (es)
DE (2) DE4037440A1 (es)
ES (1) ES2073097T3 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19533882A1 (de) 1995-09-13 1997-03-20 Dresden Arzneimittel Herstellung und Verwendung der reinen Enantiomere der 8-Halogen-6-hydroxyoctansäuren, ihrer Alkylester und ihrer Salze mit reinen Enantiomeren des alpha-Methylbenzylamins
DE19601787C1 (de) * 1996-01-19 1997-07-24 Asta Medica Ag Herstellung und Verwendung von Salzen der 6,8-Bis(amidiniumthio)-octansäure
DE19709069C2 (de) * 1997-03-06 2000-04-06 Asta Medica Ag Enantiomerenreine 3-Hydroxyoctandisäurediester, Verfahren zur Herstellung derselben durch asymmetrische katalytische Hydrierung sowie Verfahren zur Herstellung von R-(+)- und S-(-)-alpha-Liponsäure
DE19726519A1 (de) * 1997-06-23 1998-12-24 Asta Medica Ag Verfahren zur Herstellung trockener Thioctsäure
DE19834608A1 (de) 1998-07-31 2000-02-03 Basf Ag Kristallmodifikation der Liponsäure
DE10036516A1 (de) 2000-07-27 2002-02-07 Asta Medica Ag Verfahren zur Herstellung von enantiomerenreinen 6,8-Dihydroxyoctansäureestern durch assymetrische katalytische Hydrierung
ATE342371T1 (de) 2000-07-27 2006-11-15 Meda Pharma Gmbh & Co Kg Verfahren zur enantioselektiven reduktion von 8- chlor-6-oxo-octansäurealkylestern
DE10038038A1 (de) * 2000-08-02 2002-02-21 Basf Ag Verfahren zur Herstellung von Liponsäure und Dihydroliponsäure
EP1307442A2 (de) * 2000-08-02 2003-05-07 Basf Aktiengesellschaft Verfahren zur herstellung von liponsäure und dihydroliponsäure
CA2430073A1 (en) * 2000-11-30 2002-06-06 Basf Aktiengesellschaft Method for producing lipoic acid and dihydrolipoic acid
DE10137381A1 (de) 2001-07-31 2003-02-13 Viatris Gmbh Neue Modifikationen des Trometamolsalzes der R-Thioctsäure sowie Verfahren zu ihrer Herstellung
DE10152113C1 (de) * 2001-10-23 2003-03-06 Viatris Gmbh Verfahren zur Herstellung von (R)- und (S)-8-Chlor-6-hydroxy-octansäurealkylestern durch enzymatische Reduktion
DE10160148A1 (de) * 2001-12-07 2003-06-18 Basf Ag Verfahren zur Herstellung von Dihydroxycarbonsäureestern
DE10160149A1 (de) 2001-12-07 2003-06-18 Basf Ag Verfahren zur Herstellung von Dihydroxycarbonsäureestern in Abwesenheit von Lösungsmitteln
DE10255242A1 (de) 2002-11-26 2004-06-03 Basf Ag Verfahren zur Reinigung von Liponsäure
RU2011124739A (ru) * 2008-12-01 2013-01-10 Инваск Терапьютикс, Инк. Композиции, содержащие ингибиторы системы ренин-ангиотензин альдостерона и соединения липоевой кислоты, и их применение для лечения заболеваний, связанных с системой ренин-ангиотензин альдостерона

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2875227A (en) * 1955-05-11 1959-02-24 Merck & Co Inc Ephedrine salts of 7-carboethoxy-3-acetylthioheptanoic acid
US2875238A (en) * 1957-02-19 1959-02-24 Merck & Co Inc Intermediates useful in the synthesis of alpha-lipoic acid
DE3512911A1 (de) * 1985-04-11 1986-10-16 Degussa Ag, 6000 Frankfurt Verfahren zur herstellung von 1,2-dithiolan-3-pentansaeure (thioctsaeure)
DE3629116A1 (de) * 1986-08-27 1988-03-10 Asta Pharma Ag Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer
JP2578658B2 (ja) * 1989-02-21 1997-02-05 チッソ株式会社 光学活性化合物及びその製造法

Also Published As

Publication number Publication date
JP3140113B2 (ja) 2001-03-05
DE59105788D1 (de) 1995-07-27
DE4037440A1 (de) 1992-05-27
US5530143A (en) 1996-06-25
JPH04266850A (ja) 1992-09-22
EP0487986A3 (en) 1993-04-07
EP0487986A2 (de) 1992-06-03
EP0487986B1 (de) 1995-06-21

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