ES2072432T3 - Activadores de plasminogenos fosforilados. - Google Patents

Activadores de plasminogenos fosforilados.

Info

Publication number
ES2072432T3
ES2072432T3 ES90907178T ES90907178T ES2072432T3 ES 2072432 T3 ES2072432 T3 ES 2072432T3 ES 90907178 T ES90907178 T ES 90907178T ES 90907178 T ES90907178 T ES 90907178T ES 2072432 T3 ES2072432 T3 ES 2072432T3
Authority
ES
Spain
Prior art keywords
phosphorylated
plasminogen activator
pro
unphosphorylated
activators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90907178T
Other languages
English (en)
Inventor
Francesco Blasi
Maria Patrizia Stoppelli
Maria Rosaria Mastronicola
Karen Gjersing Welinder
Isabel Correas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2072432T3 publication Critical patent/ES2072432T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

EL ACTIVADOR PLASMINOGENO FOSFORILATADO, TALES COMO PROUROQUINASE FOSFORILATADO (PRO-U-PA), QUE ESTA SUSTANCIALMENTE LIBRE DEL ACTIVADOR PLASMINOGENO DESFOSFORILATADO; DEBE SER OBTENIDO POR FOSFORILATAR EL ACTIVADOR CON UN ENZIMA FOSFORILATADORA O POR SEPARAR EL ACTIVADOR DE UN MEZCLA DE ACTIVADORES PLASMINOGENOS FOSFORILATADOS Y DESFOSFORILATADOS. EL (PRO-U-PA) FOSFORILATADO, QUE ESTA SUSTANCIALMENTE LIBRE DEL (PRO-U-PA) DESFOSFORILATADO ES CONVERTIDO POR EL PLASMIN EN (U-PA) FOSFORILATADO. LOS ACTIVADORES TALES COMO EL PRO-U-PA FOSFORILATADO, U-PA Y EL T-PA SON UTILES COMO AGENTES TROMBOLITICOS.
ES90907178T 1989-04-14 1990-04-11 Activadores de plasminogenos fosforilados. Expired - Lifetime ES2072432T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK182289A DK182289D0 (da) 1989-04-14 1989-04-14 Modifikation af proteiner

Publications (1)

Publication Number Publication Date
ES2072432T3 true ES2072432T3 (es) 1995-07-16

Family

ID=8108312

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90907178T Expired - Lifetime ES2072432T3 (es) 1989-04-14 1990-04-11 Activadores de plasminogenos fosforilados.

Country Status (16)

Country Link
US (2) US5416006A (es)
EP (1) EP0422198B1 (es)
JP (1) JPH03505530A (es)
KR (1) KR920700285A (es)
AT (1) ATE120797T1 (es)
AU (1) AU623522B2 (es)
CA (1) CA2031210A1 (es)
DE (1) DE69018361T2 (es)
DK (1) DK182289D0 (es)
ES (1) ES2072432T3 (es)
HU (1) HUT56130A (es)
IL (1) IL94070A0 (es)
NZ (1) NZ233321A (es)
PT (1) PT93755A (es)
WO (1) WO1990012872A1 (es)
ZA (1) ZA902747B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08510742A (ja) * 1993-05-28 1996-11-12 カイロン コーポレイション ウロキナーゼレセプター活性のペプチドインヒビター
US6248715B1 (en) * 1993-06-01 2001-06-19 Chiron Corporation Method of treating a urokinase-type plasminogen activator-mediated disorder
CA2162855A1 (en) 1993-06-01 1994-12-08 Steven Rosenberg Expression of urokinase plasminogen activator inhibitors
US6936587B1 (en) * 1997-07-25 2005-08-30 Angstrom Pharmaceuticals, Inc. Anti-invasive and anti-angiogenic compositions
US5994309A (en) * 1997-07-25 1999-11-30 Angstrom Pharmaceuticals, Inc. Anti-invasive and anti-angiogenic compositions and methods
EP1477800A4 (en) * 2002-01-31 2005-08-17 Gl Sciences Inc METHOD AND APPARATUS FOR AMINO ACID, PEPTIDE, PROTEIN, SACCHARIDE OR LIPID ANALYSIS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0190711B1 (en) * 1985-02-07 1989-04-26 Kowa Company, Ltd. Monoclonal antibodies to tissue plasminogen activator derived from human normal cells
GB8623823D0 (en) * 1986-10-03 1986-11-05 Sandoz Ltd Therapeutic lysis of fibrin blood clots

Also Published As

Publication number Publication date
NZ233321A (en) 1991-09-25
HUT56130A (en) 1991-07-29
EP0422198A1 (en) 1991-04-17
DE69018361T2 (de) 1995-08-31
US5688503A (en) 1997-11-18
ATE120797T1 (de) 1995-04-15
US5416006A (en) 1995-05-16
AU5541190A (en) 1990-11-16
AU623522B2 (en) 1992-05-14
DK182289D0 (da) 1989-04-14
WO1990012872A1 (en) 1990-11-01
KR920700285A (ko) 1992-02-19
JPH03505530A (ja) 1991-12-05
IL94070A0 (en) 1991-01-31
PT93755A (pt) 1990-11-20
DE69018361D1 (de) 1995-05-11
EP0422198B1 (en) 1995-04-05
ZA902747B (en) 1991-01-30
CA2031210A1 (en) 1990-10-15

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