DE69018361D1 - Phosphorylierte plasminogenaktivatoren. - Google Patents

Phosphorylierte plasminogenaktivatoren.

Info

Publication number
DE69018361D1
DE69018361D1 DE69018361T DE69018361T DE69018361D1 DE 69018361 D1 DE69018361 D1 DE 69018361D1 DE 69018361 T DE69018361 T DE 69018361T DE 69018361 T DE69018361 T DE 69018361T DE 69018361 D1 DE69018361 D1 DE 69018361D1
Authority
DE
Germany
Prior art keywords
phosphorylated
plasminogen activator
pro
unphosphorylated
plasminogen activators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69018361T
Other languages
English (en)
Other versions
DE69018361T2 (de
Inventor
Francesco Blasi
Maria Patrizia Stoppelli
Maria Rosaria Mastronicola
Karen Gjersing Welinder
Isabel Correas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Blasi Francesco Milano It
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of DE69018361D1 publication Critical patent/DE69018361D1/de
Application granted granted Critical
Publication of DE69018361T2 publication Critical patent/DE69018361T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE69018361T 1989-04-14 1990-04-11 Phosphorylierte plasminogenaktivatoren. Expired - Fee Related DE69018361T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK182289A DK182289D0 (da) 1989-04-14 1989-04-14 Modifikation af proteiner
PCT/DK1990/000096 WO1990012872A1 (en) 1989-04-14 1990-04-11 Phosphorylated plasminogen activators

Publications (2)

Publication Number Publication Date
DE69018361D1 true DE69018361D1 (de) 1995-05-11
DE69018361T2 DE69018361T2 (de) 1995-08-31

Family

ID=8108312

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69018361T Expired - Fee Related DE69018361T2 (de) 1989-04-14 1990-04-11 Phosphorylierte plasminogenaktivatoren.

Country Status (16)

Country Link
US (2) US5416006A (de)
EP (1) EP0422198B1 (de)
JP (1) JPH03505530A (de)
KR (1) KR920700285A (de)
AT (1) ATE120797T1 (de)
AU (1) AU623522B2 (de)
CA (1) CA2031210A1 (de)
DE (1) DE69018361T2 (de)
DK (1) DK182289D0 (de)
ES (1) ES2072432T3 (de)
HU (1) HUT56130A (de)
IL (1) IL94070A0 (de)
NZ (1) NZ233321A (de)
PT (1) PT93755A (de)
WO (1) WO1990012872A1 (de)
ZA (1) ZA902747B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960702846A (ko) * 1993-05-28 1996-05-23 로버트 피. 블랙버언 우로키나제 리셉터 활성의 펩티드 저해인자(peptide inhbitors of urokinase receptor activity)
US6248715B1 (en) * 1993-06-01 2001-06-19 Chiron Corporation Method of treating a urokinase-type plasminogen activator-mediated disorder
EP0802983B1 (de) 1993-06-01 2003-05-02 Chiron Corporation Expression von inhibitoren vom plasminogenaktivator vom urokinasetyp
US5994309A (en) 1997-07-25 1999-11-30 Angstrom Pharmaceuticals, Inc. Anti-invasive and anti-angiogenic compositions and methods
US6936587B1 (en) * 1997-07-25 2005-08-30 Angstrom Pharmaceuticals, Inc. Anti-invasive and anti-angiogenic compositions
EP1477800A4 (de) * 2002-01-31 2005-08-17 Gl Sciences Inc Verfahren und vorrichtung zur aminosäure-, peptid-, protein-, saccharid- oder lipidanalyse

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0190711B1 (de) * 1985-02-07 1989-04-26 Kowa Company, Ltd. Monoklonale Antikörper gegen den Gewebeplasminogenaktivator von normalen menschlichen Zellen
GB8623823D0 (en) * 1986-10-03 1986-11-05 Sandoz Ltd Therapeutic lysis of fibrin blood clots

Also Published As

Publication number Publication date
US5688503A (en) 1997-11-18
HUT56130A (en) 1991-07-29
KR920700285A (ko) 1992-02-19
US5416006A (en) 1995-05-16
NZ233321A (en) 1991-09-25
ATE120797T1 (de) 1995-04-15
ZA902747B (en) 1991-01-30
AU623522B2 (en) 1992-05-14
CA2031210A1 (en) 1990-10-15
PT93755A (pt) 1990-11-20
IL94070A0 (en) 1991-01-31
DE69018361T2 (de) 1995-08-31
WO1990012872A1 (en) 1990-11-01
EP0422198B1 (de) 1995-04-05
DK182289D0 (da) 1989-04-14
EP0422198A1 (de) 1991-04-17
AU5541190A (en) 1990-11-16
JPH03505530A (ja) 1991-12-05
ES2072432T3 (es) 1995-07-16

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: BLASI, FRANCESCO, MILANO, IT

8381 Inventor (new situation)

Free format text: ERFINDER IST ANMELDER

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee