ES2072293T3 - Solvatos del diclorhidrato de ceftazidima con acido formico. - Google Patents
Solvatos del diclorhidrato de ceftazidima con acido formico.Info
- Publication number
- ES2072293T3 ES2072293T3 ES89301004T ES89301004T ES2072293T3 ES 2072293 T3 ES2072293 T3 ES 2072293T3 ES 89301004 T ES89301004 T ES 89301004T ES 89301004 T ES89301004 T ES 89301004T ES 2072293 T3 ES2072293 T3 ES 2072293T3
- Authority
- ES
- Spain
- Prior art keywords
- formic acid
- diclorhydrate
- ceftazidyme
- solvates
- ceftazidime
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- BDAGIHXWWSANSR-UHFFFAOYSA-N Formic acid Chemical compound OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 title abstract 5
- 239000012453 solvate Substances 0.000 title abstract 3
- 235000019253 formic acid Nutrition 0.000 title abstract 2
- JLZLIGALAZXURA-ZYMGEXDGSA-N (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxylatopropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;hydron;dihydrochloride Chemical compound Cl.Cl.S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC(C)(C)C(O)=O)C=2N=C(N)SC=2)CC=1C[N+]1=CC=CC=C1 JLZLIGALAZXURA-ZYMGEXDGSA-N 0.000 abstract 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
- 229960000484 ceftazidime Drugs 0.000 abstract 1
- NMVPEQXCMGEDNH-TZVUEUGBSA-N ceftazidime pentahydrate Chemical compound O.O.O.O.O.S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC(C)(C)C(O)=O)C=2N=C(N)SC=2)CC=1C[N+]1=CC=CC=C1 NMVPEQXCMGEDNH-TZVUEUGBSA-N 0.000 abstract 1
- 150000004686 pentahydrates Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888802622A GB8802622D0 (en) | 1988-02-05 | 1988-02-05 | Chemical compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2072293T3 true ES2072293T3 (es) | 1995-07-16 |
Family
ID=10631146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES89301004T Expired - Lifetime ES2072293T3 (es) | 1988-02-05 | 1989-02-02 | Solvatos del diclorhidrato de ceftazidima con acido formico. |
Country Status (9)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7452555B2 (en) * | 2003-01-21 | 2008-11-18 | S.S.C.I., Inc. | Cocrystallization |
| EP2292585B1 (en) | 2004-03-12 | 2016-04-27 | Aptuit (West Lafayette), LLC | Screening for solid forms by ultrasound crystallization and cocrystallization using ultrasound |
| HUP0700353A2 (en) * | 2007-05-18 | 2008-12-29 | Richter Gedeon Nyrt | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
| EP2251011B1 (en) * | 2008-02-21 | 2012-04-04 | Richter Gedeon Nyrt. | Solid preparation for oral administration |
| RS53866B1 (en) | 2008-07-16 | 2015-08-31 | Richter Gedeon Nyrt. | Pharmaceutical formulations containing dopamine receptor ligands |
| US11274087B2 (en) | 2016-07-08 | 2022-03-15 | Richter Gedeon Nyrt. | Industrial process for the preparation of cariprazine |
| US11547707B2 (en) | 2019-04-10 | 2023-01-10 | Richter Gedeon Nyrt. | Carbamoyl cyclohexane derivatives for treating autism spectrum disorder |
| KR20210015065A (ko) | 2019-07-31 | 2021-02-10 | 김윤성 | 운전자의 개성을 표현하고 운전자, 보행자, 자동차를 보호하기 위한 차량용 보호 케이스 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR229883A1 (es) * | 1978-05-26 | 1983-12-30 | Glaxo Group Ltd | Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato |
| US4329453A (en) * | 1979-10-02 | 1982-05-11 | Glaxo Group Limited | Cephalosporin antibiotic |
| CH644609A5 (de) * | 1979-10-02 | 1984-08-15 | Glaxo Group Ltd | Cephalosporinantibiotikum. |
| EP0113568B1 (en) * | 1982-12-27 | 1990-04-04 | Eli Lilly And Company | Intermediates for the preparation of ceftazidine, and process for their preparation |
| US4537959A (en) * | 1984-03-26 | 1985-08-27 | Eli Lilly And Company | Crystalline cephalosporin antibiotic salt |
| EP0166580A3 (en) * | 1984-06-25 | 1987-03-18 | Eli Lilly And Company | Improvements in or relating to ceftazidime |
| US4616080A (en) * | 1984-07-02 | 1986-10-07 | Eli Lilly And Company | Simplified process of forming crystalline ceftazidime pentahydrate |
-
1988
- 1988-02-05 GB GB888802622A patent/GB8802622D0/en active Pending
-
1989
- 1989-02-02 EP EP89301004A patent/EP0327358B1/en not_active Expired - Lifetime
- 1989-02-02 DE DE68922629T patent/DE68922629T2/de not_active Expired - Lifetime
- 1989-02-02 ES ES89301004T patent/ES2072293T3/es not_active Expired - Lifetime
- 1989-02-02 AT AT89301004T patent/ATE122678T1/de not_active IP Right Cessation
- 1989-02-03 JP JP1024143A patent/JP2780800B2/ja not_active Expired - Lifetime
- 1989-02-03 US US07/305,541 patent/US4943632A/en not_active Expired - Lifetime
- 1989-02-04 TW TW078100842A patent/TW266212B/zh active
- 1989-02-04 KR KR1019890001322A patent/KR0123015B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH01308284A (ja) | 1989-12-12 |
| KR890013031A (ko) | 1989-09-21 |
| DE68922629D1 (de) | 1995-06-22 |
| GB8802622D0 (en) | 1988-03-02 |
| TW266212B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1995-12-21 |
| EP0327358B1 (en) | 1995-05-17 |
| DE68922629T2 (de) | 1995-10-19 |
| KR0123015B1 (ko) | 1997-11-13 |
| EP0327358A3 (en) | 1991-04-03 |
| US4943632A (en) | 1990-07-24 |
| JP2780800B2 (ja) | 1998-07-30 |
| ATE122678T1 (de) | 1995-06-15 |
| EP0327358A2 (en) | 1989-08-09 |
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| UA7208A1 (uk) | Спосіб одержання пентагідрату (6r,7r)-7-[(z)-2-(2-амінотіазол-4-іл)-2-(2-карбоксіпроп-2-оксііміно)-ацетамідо]-3-(1-пирідинійметил)-цеф-3-ем-4-карбоксилату | |
| ES2072293T3 (es) | Solvatos del diclorhidrato de ceftazidima con acido formico. | |
| IL58717A (en) | Derivatives of(6r,7r)-7-((z)-2-(2-aminothiazol-4-yl)-2-(carboxy-(lower alkyl or cycloalkyl)oxyimino)acetamido)-3-(2-alkyl-pyrazolium-1-ylmethyl)ceph-3-em-4-carboxylate,process for their preparation and pharmaceutical compositions comprising them | |
| AU571506B2 (en) | Cristalline ceftazidime | |
| HK17089A (en) | Improvements in or relating to novel cephalosporin intermediates | |
| ES8702918A1 (es) | Un procedimiento para la preparacion de dihidrobromuro de acido (6r,7r)-7-((z)-2-(2-tritilaminotiazol-4-il)-2-(2-t-butiloxicarbonil-prop-2-oximino)acetamido)-3-(1piridiniometil)-3-cefem-4-carboxilico cristalino. | |
| ATE31535T1 (de) | Cephalosporinverbindungen. | |
| SE8701192D0 (sv) | Nya 2-aminotiazolderivat eller salter derav for framstellning av 2-(2-aminotiazol-4-yl)-glyoxylsyraderivat eller ett salt derav samt forfarande for framstellning av dessa | |
| ES513929A0 (es) | Procedimiento para la obtencion de cefalosporina 7-aca. | |
| ES8501768A1 (es) | Procedimiento para preparar (6r, 7r)-7-( (z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oximino)-acetamido)-3-(1-piridiniometil)-cef-3-em-carboxilato x 1, 5 moles de agua, cristalizado | |
| EP0377987A3 (en) | Acylation process for obtaining cephalosporin derivatives | |
| DK536986A (da) | Cephalosporinderivater, deres fremstilling og anvendelse | |
| ATE82977T1 (de) | Kristalline cephalosporinderivate. | |
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| NO884486L (no) | Fremgangsmaate for fremstilling av cefalosporinderivater med forbedrede farmakokinetika. | |
| EP0186706A4 (en) | Process for preparing cephalosporin derivatives. | |
| IT7920115A0 (it) | Procedimento per la produzione di antibiotici derivati dall'acido 7-ammino cefalosporanico. | |
| JPS52108994A (en) | Antibiotics of cephalosporin series | |
| FI864694A7 (fi) | (6R,7R)-7-/4-halogeeni-2- (hydroksi-imino)-asetoasetamido/-8-okso-3-(substituoitu tiometyyli)-5 -tia-1-atsabisyklo/4.2.0/okt-2-eeni-2-karboksyylihappojohdannaisia. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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