ES2072138T3 - N-(mercaptoalquil) amidas. - Google Patents
N-(mercaptoalquil) amidas.Info
- Publication number
- ES2072138T3 ES2072138T3 ES92901485T ES92901485T ES2072138T3 ES 2072138 T3 ES2072138 T3 ES 2072138T3 ES 92901485 T ES92901485 T ES 92901485T ES 92901485 T ES92901485 T ES 92901485T ES 2072138 T3 ES2072138 T3 ES 2072138T3
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- aryl
- alkyl
- hydrogen
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/42—Y being a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE DESCRIBEN NUEVAS AMIDAS N-(MERCAPTOALQUILO) DE LA FORMULA (I), EN LA QUE R1 ES ALQUILO INFERIOR, ALQUILO CICLO INFERIOR, ARILO O HETEROARILO; R2 ES (COR3)-ARILO, HETEROARILO, (COR3)ARILO SUSTITUIDO O HETEROARILO SUSTITUIDO, EN DONDE LOS SUSTITUYENTES SON 1-3 SUSTITUYENTES SELECCIONADOS DEL GRUPO COMPUESTO DE CARBOXI, ALCOXICARBONILO, ALQUILO INFERIOR, HIDROXI, ALCOXI INFERIOR, ALQUILO CICLO INFERIOR, CIANO, TRIFLUOROMETILO,FENILO, FENOXI Y FENILTIO; R3 ES -OR4 O N-R4R5; R4 Y R5 ESTAN SELECCIONADOS DE MODO INDEPENDIENTE DEL GRUPO COMPUESTO DE HIDROGENO, ALQUILO INFERIOR, HIDROXI ALQUILO INFERIOR,ALCOXI INFERIOR ALQUILO INFERIOR Y ARILO ALQUILO INFERIOR, O R4 Y R5 JUNTOS CON EL NITROGENO AL CUAL ESTA UNIDOS FORMAN UN ANILLO DE 5, 6 O 7 MIEMBROS; Q ES HIDROGENO O R6CO-; R6 ES HIDROGENO, ALQUILO INFERIOR O ARILO; Y M ES 1 O 2; Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE ELLOS UTILES EN EL TRATAMIENTO DE TRASTORNOS CARCIOVASCULARES, NEFROTOXICIDAD Y CONDICIONES DOLOROSAS, ASI COMO COMBINACIONES DE N(MERCAPTOALQUILO)AMIDAS Y FACTORES NATRIURETICOS ATRIALES O ANGIOTENSORES QUE CONVIERTEN INHIBIDORES ENZIMATICOS, UTILES PARA TRATAR LOS TRASTORNOS CARDIOVASCULARES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/633,696 US5232920A (en) | 1990-12-21 | 1990-12-21 | N-(mercaptoalkyl)amides |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2072138T3 true ES2072138T3 (es) | 1995-07-01 |
Family
ID=24540737
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92901485T Expired - Lifetime ES2072138T3 (es) | 1990-12-21 | 1991-12-19 | N-(mercaptoalquil) amidas. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5232920A (es) |
EP (1) | EP0563153B1 (es) |
JP (1) | JP2511625B2 (es) |
AT (1) | ATE119879T1 (es) |
AU (1) | AU9104691A (es) |
DE (1) | DE69108262T2 (es) |
DK (1) | DK0563153T3 (es) |
ES (1) | ES2072138T3 (es) |
IE (1) | IE73256B1 (es) |
IL (1) | IL100427A0 (es) |
NZ (1) | NZ241063A (es) |
PT (1) | PT99861A (es) |
TW (1) | TW199139B (es) |
WO (1) | WO1992011235A1 (es) |
ZA (1) | ZA9110014B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5177064A (en) * | 1990-07-13 | 1993-01-05 | University Of Florida | Targeted drug delivery via phosphonate derivatives |
US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
US5654294A (en) * | 1993-05-13 | 1997-08-05 | Bristol-Myers Squibb | Spiro lactam dual action inhibitors |
US5508272A (en) * | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
US5362727A (en) * | 1993-07-26 | 1994-11-08 | Bristol-Myers Squibb | Substituted azepino[2,1-a]isoquinoline compounds |
US5462964A (en) * | 1993-10-20 | 1995-10-31 | The Du Pont Merck Pharmaceutical Company | Dipeptide boronic acid inhibitors of trypsin-like enzymes |
US5616775A (en) * | 1994-05-05 | 1997-04-01 | Bristol-Myers Squibb Co. | Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring |
US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
US5877313A (en) | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
EP3282937A4 (en) * | 2015-04-14 | 2018-11-21 | Nueon Inc. | Method and apparatus for determining markers of health by analysis of blood |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4256761A (en) * | 1979-07-13 | 1981-03-17 | Usv Pharmaceutical Corporation | Antihypertensive amides |
US4820729A (en) * | 1981-03-30 | 1989-04-11 | Rorer Pharmaceutical Corporation | N-substituted-amido-amino acids |
US4470973A (en) * | 1982-07-19 | 1984-09-11 | E. R. Squibb & Sons, Inc. | Substituted peptide compounds |
EP0161769B1 (en) * | 1984-04-02 | 1987-10-28 | E.R. Squibb & Sons, Inc. | Enkephalinase inhibitors |
FR2589468B1 (fr) * | 1985-07-30 | 1987-12-31 | Roussel Uclaf | Nouveaux derives du 2-acylamino ethanethiol 2-substitue, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
US4740499A (en) * | 1986-07-28 | 1988-04-26 | Monsanto Company | Method of enhancing the bioactivity of atrial peptides |
-
1990
- 1990-12-21 US US07/633,696 patent/US5232920A/en not_active Expired - Fee Related
-
1991
- 1991-12-19 PT PT99861A patent/PT99861A/pt not_active Application Discontinuation
- 1991-12-19 DE DE69108262T patent/DE69108262T2/de not_active Expired - Fee Related
- 1991-12-19 NZ NZ241063A patent/NZ241063A/en unknown
- 1991-12-19 TW TW080109946A patent/TW199139B/zh active
- 1991-12-19 ZA ZA9110014A patent/ZA9110014B/xx unknown
- 1991-12-19 WO PCT/US1991/009189 patent/WO1992011235A1/en active IP Right Grant
- 1991-12-19 AT AT92901485T patent/ATE119879T1/de not_active IP Right Cessation
- 1991-12-19 DK DK92901485.0T patent/DK0563153T3/da active
- 1991-12-19 JP JP4501584A patent/JP2511625B2/ja not_active Expired - Fee Related
- 1991-12-19 EP EP92901485A patent/EP0563153B1/en not_active Expired - Lifetime
- 1991-12-19 AU AU91046/91A patent/AU9104691A/en not_active Abandoned
- 1991-12-19 ES ES92901485T patent/ES2072138T3/es not_active Expired - Lifetime
- 1991-12-19 IL IL100427A patent/IL100427A0/xx unknown
- 1991-12-20 IE IE448791A patent/IE73256B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IE914487A1 (en) | 1992-07-01 |
DE69108262T2 (de) | 1995-07-06 |
IE73256B1 (en) | 1997-05-21 |
JP2511625B2 (ja) | 1996-07-03 |
TW199139B (es) | 1993-02-01 |
IL100427A0 (en) | 1992-09-06 |
EP0563153B1 (en) | 1995-03-15 |
EP0563153A1 (en) | 1993-10-06 |
WO1992011235A1 (en) | 1992-07-09 |
AU9104691A (en) | 1992-07-22 |
JPH05509331A (ja) | 1993-12-22 |
ZA9110014B (en) | 1992-08-26 |
DK0563153T3 (da) | 1995-05-29 |
NZ241063A (en) | 1995-04-27 |
DE69108262D1 (de) | 1995-04-20 |
ATE119879T1 (de) | 1995-04-15 |
US5232920A (en) | 1993-08-03 |
PT99861A (pt) | 1992-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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