ES2070103T1 - Ciclobutenodionas derivadas de triptaminas contra las migrañas. - Google Patents

Ciclobutenodionas derivadas de triptaminas contra las migrañas.

Info

Publication number
ES2070103T1
ES2070103T1 ES94402059T ES94402059T ES2070103T1 ES 2070103 T1 ES2070103 T1 ES 2070103T1 ES 94402059 T ES94402059 T ES 94402059T ES 94402059 T ES94402059 T ES 94402059T ES 2070103 T1 ES2070103 T1 ES 2070103T1
Authority
ES
Spain
Prior art keywords
migrains
cyclobutenodionas
tryptamines
derivative
cyclobutenodiona
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES94402059T
Other languages
English (en)
Other versions
ES2070103T3 (es
Inventor
Jonas A Gylys
Edward H Ruediger
David W Smith
Carola Solomon
Joseph P Yevich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ES2070103T1 publication Critical patent/ES2070103T1/es
Application granted granted Critical
Publication of ES2070103T3 publication Critical patent/ES2070103T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PROPONE UNA SERIE DE NUEVOS DERIVADOS DE TRIPTAMINA SUSTITUIDA CON CICLOBUTENODIONA DE FORMULA I PARA USO EN EL ALIVIO DE JAQUECAS VASCULARES.
ES94402059T 1993-09-16 1994-09-14 Derivados de ciclobutenodionatriptaminas contra la migraña. Expired - Lifetime ES2070103T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/122,112 US5382592A (en) 1993-09-16 1993-09-16 Antimigraine cyclobutenedione derivatives of tryptamines

Publications (2)

Publication Number Publication Date
ES2070103T1 true ES2070103T1 (es) 1995-06-01
ES2070103T3 ES2070103T3 (es) 1998-11-01

Family

ID=22400690

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94402059T Expired - Lifetime ES2070103T3 (es) 1993-09-16 1994-09-14 Derivados de ciclobutenodionatriptaminas contra la migraña.

Country Status (10)

Country Link
US (1) US5382592A (es)
EP (1) EP0644187B1 (es)
JP (1) JPH07179344A (es)
AT (1) ATE167853T1 (es)
AU (1) AU671925B2 (es)
CA (1) CA2130519A1 (es)
DE (2) DE69411339T2 (es)
DK (1) DK0644187T3 (es)
ES (1) ES2070103T3 (es)
GR (1) GR950300041T1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
CA2508290C (en) * 2002-12-20 2017-02-28 Ciba Specialty Chemicals Holding Inc. Synthesis of amines and intermediates for the synthesis thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1170387B (it) * 1982-06-07 1987-06-03 Glaxo Group Ltd Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
GB2162522B (en) * 1984-08-01 1988-02-24 Glaxo Group Ltd An indole derivative
GB8924373D0 (en) * 1989-10-30 1989-12-20 Beecham Group Plc Novel compounds
GB9104136D0 (en) * 1991-02-27 1991-04-17 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
DE69411339T2 (de) 1999-04-08
DK0644187T3 (da) 1999-04-12
ATE167853T1 (de) 1998-07-15
ES2070103T3 (es) 1998-11-01
EP0644187B1 (en) 1998-07-01
CA2130519A1 (en) 1995-03-17
JPH07179344A (ja) 1995-07-18
GR950300041T1 (en) 1995-07-31
AU7297494A (en) 1995-03-30
DE644187T1 (de) 1995-10-12
DE69411339D1 (de) 1998-08-06
US5382592A (en) 1995-01-17
EP0644187A1 (en) 1995-03-22
AU671925B2 (en) 1996-09-12

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